2011 Annual Report 1a.Objectives (from AD-416) To devise innovative methods for the suppression of insects that transmit diseases to U.S. military deployed abroad. 1b.Approach (from AD-416) Identify and test compounds with insecticidal activity that makes them especially beneficial in the rapid control o fmosquitoes, flies, and other arthropods responsible for carrying disease agent. Devise innovative means of applying control agents especially suited for use in combat or deployment conditions. Identify and test new classes of topical and area repellents for use by troops. 3.Progress Report This joint initiative is to develop and validate novel methods to protect U.S. military personnel deployed abroad from threats posed by insects and ticks that transmit disease-causing pathogens. Laboratory bioassays have been used to screen chemicals developed by laboratory personnel for their ability to deter blood-sucking mosquitoes. This reporting period we streamlined two fast acting pyrethroids for product development and pursued formulation for Velcro pallets to create repellent barrier. We also developed series of novel commercially viable lactam repellents for topical formulation. Invention disclosure (docket # 0152.11) concerning lactam repellents was developed. US patent application (USPA# 13/181,914) for Improved Repellent-Treatment Clothing System for Prevention of Art was filed after optimizing claims.