1a.Objectives (from AD-416):
Determine if 50,000 IU vitamin A supplementation within 48 hours of birth will (1) improve thyrmus function; (2) enhance vaccine reponses; and (3) decrease incidence of infections.
1b.Approach (from AD-416):
A community-based intervention trial in Dhaka, Bangladesh.
This research relates to objective 4 of the inhouse project, “Determine if high-level vitamin A intake is associated with higher Th2 and Treg responses and lower Th1 and Th17 responses relative to adequate and deficient intake". This intervention trial began recruiting in December of 2012 and the final study visit was in August of 2013, with a final recruitment level of 304 newborn infants followed through 15 weeks of age. Laboratory work continues in Dhaka at the International Centre for Diarrhoeal Disease Research, Bangladesh, and in Davis, California, at the Western Human Nutrition Research Center, with samples shipped from Bangladesh.