2011 Annual Report 1a.Objectives (from AD-416) This cooperative research project focuses on the study of the pathogenicity of Foot-and-Mouth Disease Virus (FMDV) Korean isolates, A/ROK/2010 and O/ROK/2010 in pigs and cattle. Specific objectives are: 1. Conduct a time-course study of FMD infection in pigs and cattle; including direct transmission, 2. Obtain and catalog quality pictures of lesions and reference stocks of research material; serum and tissues. 1b.Approach (from AD-416) NVRQS will provide FMDV A/ROK/2010 and O/ROK/2010 from pigs and cattle, as well as conduct epidemiological analysis and conduct genomic sequencing of viral isolates. ARS, PIADC will conduct FMDV pathogenicity studies on swine and cattle, inclusive of time-course study and histopathological evaluation and sample collection. NVRQS scientists will be trained to conduct research on FMDV pathogenesis using methology developed by ARS, PIADC scientists. Data generated will help to develop and upgrade current diagnostic assays for the detection of FMD circulating in south east Asia. 3.Progress Report Transfer of the serotype A and O viral strains from Korea to ARS, PIADC. Work has begun on the preparation of master stocks of some of these strains in cattle and swine and will continue in FY 2012.