2011 Annual Report 1a.Objectives (from AD-416) The objective of this cooperative research project is to jointly study avian influenza viruses, paramyxoviruses, pneumoviruses and other viral agents of poultry that potential can cross between birds and humans. 1b.Approach (from AD-416) The studies will use immunological, virological, molecular, genetic, and pathological methodologies and animal models to study the pathogenesis, immunology, vaccine safety and efficacy, therapeutics and epidemiology of the viruses and infections they cause. 3.Progress Report This research is related to inhouse objective 2: Develop vaccines that effectively stop outbreaks, allow differentiation from natural infection and can be administered in a cost effective manner. Two clade 2.3.2.1 H5N1 high pathogenicity avian influenza viruses from Vietnam were received under the non-funded cooperative agreement. Experimental plans have been developed to test these viruses against existing vaccines used in poultry in Vietnam. Progress was monitored via email and phone calls with cooperator.