1a.Objectives (from AD-416):
Objective:. 1)Determine bone density;. 2)determine bone metabolism;. 3)evaluate calcium losses from the skeleton.
1b.Approach (from AD-416):
Conduct a human study using 41Ca isotope tracer to quantify calcium losses directly from the skeleton in postmenopausal women. Sixteen healthy postmenopausal women will be enrolled and labeled with 41Ca tracer. Following tracer equilibration (~6mo.)women will be randomly assigned to 1 of 2 treatments:. 1)3-4 servings/d milk or. 2)equivalent calcium citrate supplementation. Following first intervention women will cross-over to the other intervention. Urine and sera samples will be collected and analyzed for 41Ca excretion, bone metabolism markers, PTH and 25-(OH)vitamin D. Documents Trust with Dairy Research Institute. Log 41795.
This project relates to Objective 1 of the in-house project "to determine the effects of specific foods, nutrients, and food components that promote health and disease prevention in at-risk populations". Clinical study was completed in March of 2013. Diet records have been completed and urinary mineral excretion analysis is finished. Analysis of calcium-41 isotope is pending at Lawrence Livermore National Laboratory.