1a.Objectives (from AD-416)
Objective:. 1)Determine bone density;. 2)determine bone metabolism;. 3)evaluate calcium losses from the skeleton.
1b.Approach (from AD-416)
Conduct a human study using 41Ca isotope tracer to quantify calcium losses directly from the skeleton in postmenopausal women. Sixteen healthy postmenopausal women will be enrolled and labeled with 41Ca tracer. Following tracer equilibration (~6mo.)women will be randomly assigned to 1 of 2 treatments:. 1)3-4 servings/d milk or. 2)equivalent calcium citrate supplementation. Following first intervention women will cross-over to the other intervention. Urine and sera samples will be collected and analyzed for 41Ca excretion, bone metabolism markers, PTH and 25-(OH)vitamin D. Documents Trust with Dairy Research Institute. Log 41795.
New project to examine the effect of milk versus supplements on calcium efflux from bone has been initiated. Required radiation and human subjects approval has been obtained. Recruitment started in October, 9 women have been enrolled, dosed and are on the stabilization period. Intervention will begin in August, and continue through 2012. Funding has been obtained from the Dairy Research Institute and Dairy Council of California.