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United States Department of Agriculture

Agricultural Research Service

Research Project: Evaluation of the Heart Health Benefits Beyond Cholesterol for the Whole Grain Barley and Oats in Healthy Men and Women

Location: Food Components and Health Laboratory

2011 Annual Report


1a.Objectives (from AD-416)
To determine the effect of different cereal grains on risk factors for cardiovascular disease.


1b.Approach (from AD-416)
ARS will conduct a randomized clinical trial to investigate the effect of cereal grains on biomarkers of glucoregulatory control and cardiovascular disease. Grains will be incorporated into foods to maintain a double blind intervention.


3.Progress Report

This project is to evaluate the impact of whole grain barley and oats on cardiovascular disease risk factors and metabolic changes. Two studies were conducted. Study one was a randomized, double-blind, parallel arm intervention to investigate the health effects of chronic ingestion of whole grain barley and oats. The study included three treatments: .
1)low fiber control,.
2)whole grain barley, and.
3)whole grain oats. The intervention included food products that were incorporated into a controlled 7-day menu rotation that were served to volunteers for 6 weeks. Products included breakfast cereal, granola, trail mix, and fruit-cereal bars to achieve 4 servings of whole grain intake per day. Subjects (n=69, approximately equal number of men and women) were stratified by gender and initial body mass index (BMI), and randomly assigned to a treatment. At the end of the intervention, blood and urine samples were collected to assess treatment differences in long-term biomarkers of glucoregulatory control and cardiovascular disease. Study two was a randomized, double-blind, crossover intervention to investigate the health effects of acute ingestion of whole grain barley and oats. The study included three treatments: .
1)a high fat, low fiber control meal,.
2)a high fat meal including whole grain barley, and.
3)a high fat meal containing whole grain oats. Subjects (n=18, approximately equal number of men and women) were randomly assigned to a treatment sequence. At the end of the intervention period, subjects underwent a meal tolerance test or an assessment of endothelial function. Analyses are ongoing. Activities and progress of this agreement were monitored through site visits, conference calls, and email correspondence.


Last Modified: 8/22/2014
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