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United States Department of Agriculture

Agricultural Research Service

Research Project: Evaluation of the Heart Health Benefits Beyond Cholesterol for the Whole Grain Barley and Oats in Healthy Men and Women

Location: Food Components and Health Laboratory

2013 Annual Report


1a.Objectives (from AD-416):
To determine the effect of different cereal grains on risk factors for cardiovascular disease.


1b.Approach (from AD-416):
ARS will conduct a randomized clinical trial to investigate the effect of cereal grains on biomarkers of glucoregulatory control and cardiovascular disease. Grains will be incorporated into foods to maintain a double blind intervention.


3.Progress Report:

This project is to evaluate the impact of whole grain barley and oats on cardiovascular disease risk factors and metabolic changes. Two studies were conducted. Study one was a randomized, double-blind, parallel arm intervention to investigate the health effects of chronic ingestion of whole grain barley and oats. The study included three treatments: .
1)low fiber control,.
2)whole grain barley, and.
3)whole grain oats. The intervention included food products that were incorporated into a controlled 7-day menu rotation that were served to volunteers for 6 weeks. Products included breakfast cereal, granola, trail mix, and fruit-cereal bars to achieve 4 servings of whole grain intake per day. Subjects (n=69, approximately equal number of men and women) were stratified by gender and initial body mass index (BMI), and randomly assigned to a treatment. At the end of the intervention, blood and urine samples were collected to assess treatment differences in long-term biomarkers of glucoregulatory control and cardiovascular disease. Study two was a randomized, double-blind, crossover intervention to investigate the health effects of acute ingestion of whole grain barley and oats. The study included three treatments: .
1)a high fat, low fiber control meal,.
2)a high fat meal including whole grain barley, and.
3)a high fat meal containing whole grain oats. Subjects (n=18, approximately equal number of men and women) were randomly assigned to a treatment sequence. At the end of the intervention period, subjects underwent a meal tolerance test or an assessment of endothelial function. Analyses are ongoing.


Last Modified: 7/28/2014
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