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United States Department of Agriculture

Agricultural Research Service

Project Type: Reimbursable

Start Date: Jul 31, 2010
End Date: Sep 30, 2010

The objective of this agreement is to complete an evaluation of existing capacity and expand FMD research capacity including virus strain genetic characterization, vaccine quality control and real-time FMD epidemiological data analysis within Pakistan.

Successful control of FMD depends on an integrated control program that includes: 1) adequate surveillance, reporting, and laboratory capacity to detect and confirm cases; 2) adequate and effective vaccines matching the field strains circulating in the region and adequate vaccine quality control monitoring; and 3) epidemiological information based vaccination strategies targeting the highest risk areas to decrease spread. The development of tools that fit the needs and purposes of the control program in Pakistan require a local structure for data analysis, strategic planning and research capacity, ideally in partnerships between Pakistan and the US. Therefore, data gathering and analysis and research capacities are fundamental components of a successful FMD control strategy. This project will allow engagement of experts in the US (At UC-Davis and Plum Island) with Pakistani scientists to develop the necessary tools and monitoring systems in support of the progressive control and future eradication of FMD in Pakistan. The project will have two major components: 1) the use of the UC-Davis FMD Bioportal system to FMD BioPortal and to provide real time data and epidemiological information to ARS, PIADC, APHIS, FAO and local authorities to aid in the progressive FMD control program in Pakistan, 2) the determination of genomic virus sequences, antigenic vaccine matching and epidemiological data of FMD strains circulating in strategic regions of Pakistan. Combining the knowledge of epidemiology with genetic sequence and antigenic profile of FMD viral strains is a fundamental component for the progressive FMD control and eradication program in Pakistan. To facilitate this project, funds will be transferred to UC Davis and to the US Department of Energy. UC-Davis personnel will perform training of Pakistani personnel in; bio-portal administration and data analysis, and provide epidemiological support to this project . The US Department of Energy and ARS, PIADC have an inter-agency agreement which supports the Plum Island Research Participation Program managed by the Oak Ridge Institute of Science and Education (ORISE). PIADC scientists and ORISE fellows will work at the PIADC laboratories characterizing viral strains collected in Pakistan and will also travel to Pakistan to provide laboratory training, technical support and expertise to conduct field studies in collaboration with Pakistan’s Collaborating institutions including the Animal Sciences Institute, National Agriculture Research Center with whom we currently have a USDA-OIRP funded research project aimed at "Characterization of FMDV Strains And Development of Vector Vaccines"; and National Veterinary Laboratories with whom we intend to collaborate in epidemiology, diagnostics and vaccine antigenic matching testing under this project.

Last Modified: 8/31/2015
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