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United States Department of Agriculture

Agricultural Research Service

Research Project: DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCT FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Cassia Cinnamon as a source of Coumarin in cinnamon-flavored food and food supplements in the United States - (Peer Reviewed Journal)
Wang, Y., Avula, B., Nanayakkara, N., Zhao, J., Khan, I.A. 2013. Cassia Cinnamon as a source of Coumarin in cinnamon-flavored food and food supplements in the United States. Journal of Agricultural and Food Chemistry. 61:4470-4476.
Profiling primaquine metabolites in primary human hepatocytes by UPLC-QTOF-MS with 13c stable isotope labeling - (Peer Reviewed Journal)
Bharathi, A., Tekwani, B.L., Chauarasiya, N.D., Nanayakkara, D.N., Wang, Y., Khan, S.I., Adelli, V.R., Sahu, R.K., Elsohly, M.A., Mcchesney, J.D., Khan, I., Walker, L.A. 2013. Profiling primaquine metabolites in primary human hepatocytes by UPLC-QTOF-MS with 13c stable isotope labeling. Journal of Mass Spectrometry. 48(2):276-285.
Comparative study of three Plumbago L. species (Plumbaginaceae) by microscopy, UPLC–UV and HPTLC analyses - (Peer Reviewed Journal)
Galal, A.M., Raman, V., Avula, B., Wang, Y., Rumalla, C.S., Weerasooriya, A.D., Khan, I.A. 2012. Comparative study of three Plumbago L. species (Plumbaginaceae) by microscopy, UPLC–UV and HPTLC analyses. Journal of Natural Medicine. 67:554-661.
Antifungal, mosquito deterrent, and larvicidal activity of N-(benzylidene)-3-cyclohexylpropionic acid hydrazide derivatives - (Peer Reviewed Journal)
Tabanca, N., Wedge, D.E., Ali, A., Khan, I.A., Kaplancikli, Z.A., Altintop, M.D. 2012. Antifungal, misquito deterrent, and larvicidal activity of N-(benzylidene)-3-cyclohexylpropionic acid hydrazide derivatives. Research and Reports in Medicinal Chemistry. 22:2602-2609.
Antiparasitic and anticancer carvotacetone derivatives of Sphaeranthus bullatus - (Peer Reviewed Journal)
Machumi, F., Yenesew, A., Midiwo, J.O., Heydenreich, M., Kleinpeter, E., Tekwani, B.L., Khan, S.I., Walker, L.A., Muhammad, I. 2012. Antiparasitic and anticancer carvotacetone derivatives of Sphaeranthus bullatus. Natural Product Communications. 7(9):1123-1126.
An investigation of the vegetative anatomy of Piper sarmentosum, and a comparison with the anatomy of Piper betle (Piperaceae) - (Peer Reviewed Journal)
Raman, V., Galal, A.M., Khan, I.A. 2012. An investigation of the vegetative anatomy of Piper sarmentosum, and a comparison with the anatomy of Piper betle (Piperaceae). American Journal of Plant Sciences. 3:1135-1144.
Bioconversion of 7-hydroxyflavanone: isolation, characterization and bioactivity evaluation of twenty-one phase I and phase II microbial metaboites - (Peer Reviewed Journal)
Mikell, J.R., Khan, I.A. 2012. Bioconversion of 7-hydroxyflavanone: isolation, characterization and bioactivity evaluation of twenty-one phase I and phase II microbial metaboites. Chemical and Pharmaceutical Bulletin. 60(9):1139-1145.
Quantitative determination of alkaloids from roots of Hydrastis canadensis L. and dietary supplements using UPLC-UV-MS - (Peer Reviewed Journal)
Avula, B., Wang, Y., Khan, I.A. 2012. Quantitative determination of alkaloids from roots of Hydrastis canadensis L. and dietary supplements using UPLC-UV-MS. Official Methods of Analysis of AOAC International. 95(5)1398-1405.
Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani - (Peer Reviewed Journal)
Zhang, X., Jacob, M.R., Rao, R.R., Wang, Y., Agarwal, A.K., Newman, D.J., Khan, I.A., Clark, A.M., Li, X. 2012. Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani. Journal of Medicinal Chemistry. 2:7-14.
Exploring the molecular basis of antifungal synergies using genome-wide approaches - (Review Article)
Agarwal, A.K., Tripathi, S.K., Xu, T., Jacob, M.R., Li, X., Clark, A.M. 2012. Exploring the molecular basis of antifungal synergies using genome-wide approaches. Frontiers in Microbiology. (3)15:1-6.
Quantitative determination of curcuminoids from the Roots of Curcuma longa, Curcuma species and dietary supplements using an UPLC-UV-MS method - (Peer Reviewed Journal)
Avula, B., Wang, Y., Khan, I.A. 2012. Quantitative determination of curcuminoids from the Roots of Curcuma longa, Curcuma species and dietary supplements using an UPLC-UV-MS method. Journal of Chromatography. 3(1):1-6.
Comparison of concentration pulse and tracer pulse chromatography: experimental determination of eluent uptake by bridged-ethylene hybrid ultra high performance liquid chromatography packings - (Peer Reviewed Journal)
Wang, M., Avula, B., Parcher, J.F., Khan, I.A. 2011. Comparison of concentration pulse and tracer pulse chromatography: experimental determination of eluent uptake by bridged-ethylene hybrid ultra high performance liquid chromatography packings. Journal of Chromatography A. 1220:75-81.
Antifungal compounds from Piper species - (Peer Reviewed Journal)
Xu, W., Li, X. 2011. Antifungal compounds from Piper species. Current Bioactive Compounds. 7(4):262-267.
Why are there no new herbicide modes of action in recent years - (Peer Reviewed Journal)
Duke, S.O. 2012. Why are there no new herbicide modes of action in recent years. Pest Management Science. 68:505-512.
Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome - (Peer Reviewed Journal)
Khan, S.I., Aumsuwan, P., Khan, I.A., Walker, L.A., Dasmahapatra, A.K. 2011. Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome. Chemical Research in Toxicology. 25:61-73.
Sampangine inhibits heme biosynthesis in both yeast and human - (Peer Reviewed Journal)
Huang, Z., Chen, K., Xu, T., Zhang, J., Li, Y., Li, W., Agarwal, A.K., Clark, A.M., Phillips, J.D., Pan, X. 2011. Sampangine inhibits heme biosynthesis in both yeast and human. Eukaryotic Cell. 10(11):1536-1544.
Synthesis and antifungal activity of natural product-based 6-alkyl-2 3 4 5-tetrahydropyridines - (Peer Reviewed Journal)
Dai, L., Jacob, M.R., Khan, S.I., Khan, I.A., Clark, A.M., Li, X. 2011. Synthesis and antifungal activity of natural product-based 6-alkyl-2 3 4 5-tetrahydropyridines. Journal of Natural Products. 74(9):2023-2026.
Potential utility of natural products as regulators of breast cancer-assoicated aromatase promoters - (Peer Reviewed Journal)
Khan, S.I., Zhao, J., Khan, I.A., Walker, L.A., Dasmahapatra, A.K. 2011. Potential utility of natural products as regulators of breast cancer-assoicated aromatase promoters. Reproductive Biology and Endocrinology. 9:91-101.
Quantitative determination of triterpene saponins and alkenated-phenolics from Labisia pumila using LC-UV/ELSD method and confirmation by LC-ESI-TOF - (Peer Reviewed Journal)
Avula, B., Wang, Y., Ali, Z., Smillie, T.J., Khan, I.A., Duke, S.O. 2011. Quantitative determination of triterpene saponins and alkenated-phenolics from Labisia pumila using LC-UV/ELSD method and confirmation by LC-ESI-TOF. Planta Medica. 77:1742-1748.
Quantitative determination of triperpene saponins and alkenated-phenolics from Labisia pumila using LC-UV/ELSD method and confirmation by LC-ESI-TOF - (Peer Reviewed Journal)
Avula, B., Wang, Y., Ali, Z., Smillie, T.J., Khan, I.A. 2011. Quantitative determination of triperpene saponins and alkenated-phenolics from Labisia pumila using LC-UV/ELSD method and confirmation by LC-ESI-TOF. Planta Medica. 77:1742-1748.
Microbial metabolism Part 12 isolation characterization and bioactivity evaluation of eighteen microbial metabolites of 4'-hydroxyflavanone - (Peer Reviewed Journal)
Mikell, J.R., Herath, W., Khan, I.A. 2011. Microbial metabolism Part 12 isolation characterization and bioactivity evaluation of eighteen microbial metabolites of 4'-hydroxyflavanone. Chemical and Pharmaceutical Bulletin. 59(6):692-697.
Natural product-based 6-hydroxy-2 3 4 6-tetrahydropyrrolo[1 2-a]pyrimidinium Scaffold as a new antifungal template - (Peer Reviewed Journal)
Li, X., Babu, K., Jacob, M.R., Khan, S.I., Agarwal, A.K., Clark, A.M. 2011. Natural product-based 6-hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium scaffold as a new antifungal template. ACS Medicinal Chemistry Letters. 2:391-395.
Characterization and pharmacological properties of in vitro propagated clones of Echinacea tennesseensis (Beadle) small - (Peer Reviewed Journal)
Moraes, R.M., Lata, H., Sumyanto, J., Pereira, A.M., Bertoni, B.W., Joshi, V.C., Pugh, N.D., Khan, I.A., Pasco, D.S. 2011. Characterization and pharmacological properties of in vitro propagated clones of Echinacea tennesseensis (Beadle) small. Plant Cell Tissue And Organ Culture. 106:309-315.
Chemical fingerprint analysis and quantitative determination of pregnanes from aerial parts of caralluma species using HPLC-UV and identification by LC-ESI-TOF - (Peer Reviewed Journal)
Avula, B., Shukla, Y.J., Wang, Y., Khan, I.A. 2011. Chemical fingerprint analysis and quantitative determination of pregnanes from aerial parts of caralluma species using HPLC-UV and identification by LC-ESI-TOF. Official Methods of Analysis of AOAC International. 94(5):1383-1390.
Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase - (Peer Reviewed Journal)
Liu, H., Walker, L.A., Nanayakkara, N., Doerksen, R.J. 2011. Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase. Journal of the American Chemical Society. 133:1172-1175.
Inorganic elemental compositions of commercial multivitamin/mineral dietary supplements: application of collision/reaction cell inductively coupled-mass spectroscopy - (Peer Reviewed Journal)
Avula, B., Wang, Y., Duzgoren-Aydin, N.S., Khan, I.A. 2010. Inorganic elemental compositions of commercial multivitamin/mineral dietary supplements: application of collision/reaction cell inductively coupled-mass spectroscopy. Food Chemistry. 127:54-62.
Rapid analysis of lignans from leaves of Podophyllum peltatum L samples using UPLC-UV-MS - (Peer Reviewed Journal)
Avula, B., Wang, Y., Moraes, R.M., Khan, I.A. 2011. Rapid analysis of lignans from leaves of Podophyllum peltatum L samples using UPLC-UV-MS. Biomedical Chromatography. 25:1230-1236.
Rapid analysis of lignans from leaves of Podophyllum peltatum l. samples using UPLC-UV-MS - (Peer Reviewed Journal)
Avula, B., Wang, Y., Moraes, R.M., Khan, I.A. 2011. Rapid analysis of lignans from leaves of Podophyllum peltatum l. samples using UPLC-UV-MS. Biomedical Chromatography. 25:1230-1236.
Steroidal saponins from fresh stems of Dracaena angustifolia - (Peer Reviewed Journal)
Xu, M., Zhang, Y., Li, X., Jacob, M.R., Yang, C. 2010. Steroidal saponins from fresh stems of Dracaena angustifolia. Journal of Natural Products. 73:1524-1528.
Bioactive 1 4-Dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum - (Peer Reviewed Journal)
Kumarihamy, M., Fronczek, F.R., Ferreira, D., Jacob, M., Khan, S.I., Nanayakkara, D. 2010. Bioactive 1, 4-Dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum. Journal of Natural Products. 73:1250-1253.
Last Modified: 12/28/2014
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