Location: Obesity and Metabolism Research Unit
Project Number: 5306-51530-022-01
Start Date: Aug 01, 2010
End Date: Dec 31, 2014
A completely randomized design will be used to examine effects of consuming MSG in overweight (BMI 27–32) women (N = 48), ages 19–45. Refer to the study schematic below for study design. For all subjects during the first ten weeks of the study, the goal of the weight reduction phase is to have each participant achieve a weight loss that is equivalent to 5-6% of their initial body weight. During the first week, a customized diet plan will be developed and outlined for each participant so that this degree of weight loss can be achieved within the following 9-week period. In most cases energy intake will be reduced by 500-750 kcal/day to reach this goal, depending on participant’s height and weight. We have used this approach successfully in previous studies and expect about a 5-6% loss of weight. After the nine week weight loss period, two weeks will be devoted to obtaining baseline measurements before the 12-weeks of intervention. During these weeks subjects will receive a metabolic (maintenance) diet with energy intake set to maintain current body weight. All foods will be prepared, pre-portioned, and dispensed by the dietary staff of the WHNRC metabolic kitchen. Vehicle foods (no MSG) will be provided to all subjects during baseline testing. Following the baseline testing period, subjects will be randomized to a 12 week trial where subjects will supplement daily their breakfast, lunch, and dinner with provided and commonly used food and beverage items treated with MSG (N = 24) or without MSG (N = 24). Subjects will be blinded to the intervention. Two weeks will be devoted to obtaining baseline and then post-treatment measurements at the end of the 12 weeks of intervention. During these weeks subjects will receive a metabolic diet with energy intake set to maintain current body weight.