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United States Department of Agriculture

Agricultural Research Service

Research Project: Bone Metabolism in Obesity Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Role of glucocorticoid-induced leucine zipper (GILZ) in bone acquisition - (Peer Reviewed Journal)
(04-Jun-14)
Dietary protein level and source differentially affect bone metabolism, strength, and intestinal calcium transporter expression during ad libitum and food-restricted conditions in male rats     Reprint Icon - (Peer Reviewed Journal)
Gaffney-Stomberg, E., Cao, J.J., Lin, G.G., Wulff, C.R., Murphy, N.E., Young, A.J., Mcclung, J.P., Pasiakos, S.M. 2014. Dietary protein level and source differentially affect bone metabolism, strength, and intestinal calcium transporter expression during ad libitum and food-restricted conditions in male rats. Journal of Nutrition. 144(6):821-829.
N-acetylcysteine supplementation decreases osteoclast differentiation and increases bone mass in mice fed a high-fat diet     Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Picklo, M.J. 2014. N-acetylcysteine supplementation decreases osteoclast differentiation and increases bone mass in mice fed a high-fat diet. Journal of Nutrition. 144:289-296.
Calcium homeostasis and bone metabolic responses to high-protein diets during energy deficit in healthy young adults: a randomized control trial     Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Pasiakos, S.M., Margolis, L.M., Sauter, E.R., Whigham Grendell, L.D., Mcclung, J.P., Young, A.J., Combs, G.F. 2014. Calcium homeostasis and bone metabolic responses to high-protein diets during energy deficit in healthy young adults: a randomized control trial. American Journal of Clinical Nutrition. 99:400-407.
Whole-body protein turnover response to short-term high-protein diets during weight loss: a randomized controlled trial - (Peer Reviewed Journal)
Pasiokos, S.M., Margolis, L.M., Mcclung, J.P., Cao, J.J., Whigham Grendell, L.D., Combs, G.F., Young, A.J. 2014. Whole-body protein turnover response to short-term high-protein diets during weight loss: a randomized controlled trial. International Journal of Obesity. 38(7):1015-1018.
Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis     Reprint Icon - (Peer Reviewed Journal)
Carbone, J.W., Margolis, L.M., Mcclung, J.P., Cao, J.J., Murphy, N.E., Sauter, E.R., Combs, G.F., Young, A.J., Pasiakos, S.M. 2013. Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis. Journal of Federation of American Societies for Experimental Biology. 27(12):5104-5111.
Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of CYP1 enzymes     Reprint Icon - (Peer Reviewed Journal)
Iqbal, J., Sun, L., Cao, J.J., Yuen, T., Bab, I., Leu, N., Wagage, S., Hunter, C., Nebert, D.W., Zaidi, M. 2013. Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of CYP1 enzymes. Proceedings of the National Academy of Sciences. 110(27):1115-11120.
Effects of high protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial     Reprint Icon - (Peer Reviewed Journal)
Pasiakos, S.M., Cao, J.J., Margolis, L.M., Sauter, E.R., Whigham Grendell, L.D., Mcclung, J.P., Rood, J.C., Carbone, J.W., Combs, G.F., Young, A.J. 2013. Effects of high protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial. Journal of Federation of American Societies for Experimental Biology. doi: 10.1096/fj.13-230227.
Soy protein isolates prevent loss of bone quantity associated with obesity in rats through regulation of insulin signaling in osteoblasts     Reprint Icon - (Peer Reviewed Journal)
Chen, J., Zhang, J., Laranko, O.P., Cao, J.J., Blackburn, M.L., Badger, T.M., Ronis, M.J. 2013. Soy protein isolates prevent loss of bone quantity associated with obesity in rats through regulation of insulin signaling in osteoblasts. Federation of American Societies for Experimental Biology Conference. 27(9):3514-3523.
Mx1-cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype     Reprint Icon - (Peer Reviewed Journal)
Yang, S., Li, Y., Liu, T., He, X., Yuan, X., Li, C., Cao, J.J., Kim, Y. 2013. Mx1-cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype. Genesis. 51:201-209.
Dietary protein intake, energy deficit, and nitrogen balance in normal-weight adults: a randomized controlled - (Abstract Only)
Margolis, L.M., Cao, J.J., Whigham Grendell, L.D., Mcclung, J.P., Combs, G.F., Young, A.J., Pasiakos, S.M. 2013. Dietary protein intake, energy deficit, and nitrogen balance in normal-weight adults: a randomized controlled. Federation of American Societies for Experimental Biology Conference. 27:1075.11.
Calcium homeostasis and bone metabolic responses to protein diets and energy restriction: a randomized control trial - (Abstract Only)
Cao, J.J., Pasiakos, S.M., Margolis, L.M., Whigham Grendell, L.D., Mcclung, J.P., Young, A.Y., Combs, G.F. 2013. Calcium homeostasis and bone metabolic responses to high protein diets and energy restriction: a randomized control trial. Federation of American Societies for Experimental Biology Conference. 27:249.1.
History of zinc in agriculture     Reprint Icon - (Review Article)
Nielsen, F.H. 2012. History of zinc in agriculture. Advances in Nutrition. 3:783-789.
Vitamin C reverses hypogonadal bone loss     Reprint Icon - (Peer Reviewed Journal)
Zhu, L., Cao, J.J., Sun, M., Yuen, T., Zhou, R., Li, J., Peng, Y., Moonga, S.S., Guo, L., Mechanick, J.I., Iqbal, J., Peng, L., Blair, H.C., Biam, Z., Zaidi, M. 2012. Vitamin C reverses hypogonadal bone loss. PLoS One. 7(10):1-6.
Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling     Reprint Icon - (Peer Reviewed Journal)
Baliram, R., Sun, L., Cao, J.J., Li, J., Latif, R., Huber, A.K., Yuen, T., Blair, H.C., Zaidi, M., Davies, T.F. 2012. Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling. Journal of Clinical Investigation. 122(10):3737-3741.
Blocking antibody to the beta-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis     Reprint Icon - (Peer Reviewed Journal)
Zhu, L., Blair, H.C., Cao, J.J., Yuen, T., Latif, R., Guo, L., Tourkova, I.L., Li, J., Davies, T.F., Sun, L., Bian, Z., Rosen, C., Zallone, A., New, M.I., Zaidi, M. 2012. Blocking antibody to the beta-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis. Proceedings of the National Academy of Sciences. 109(36):14574-14579.
Critical role for CCAAT/Enhancer-binding protein beta in immune complex-induced acute lung injury     Reprint Icon - (Peer Reviewed Journal)
Yan, C., Wu, M., Cao, J.J., Tang, H., Zhu, M., Johnson, P.E., Gao, H. 2012. Critical role for CCAAT/Enhancer-binding protein beta in immune complex-induced acute lung injury. Journal of Immunology. 189(3):1480-90.
Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton     Reprint Icon - (Peer Reviewed Journal)
Colaianni, G., Sun, L., Di Benedetto, A., Tamma, R., Zhu, L., Cao, J.J., Grano, M., Yuan, T., Colucci, S., Cuscito, C., Mancini, L., Li, J., Nishimori, K., Bab, I., Lee, H., Iqbal, J., Young, W., Rosen, C., Zallone, A., Zaidi, M. 2012. Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton. Proceedings of the National Academy of Sciences. 287(34):29159-29167.
Calcium, magnesium, and potassium in food - (Book / Chapter)
Nielsen, F.H. 2012. Calcium, magnesium, and potassium in food. In: Sulewski, G., editor. Fertilizing Crops to Improve Human Health: A Scientific Review. 1st edition. Norcross, GA: International Plant Nutrition Institute, p. 123-142.
Ccaat/enhancer-Binding Protein ¿ Is a Critical Regulator of Il-1ß-Induced Il-6 Production in Alveolar Epithelial Cells     Reprint Icon - (Peer Reviewed Journal)
Yan, C., Wang, X., Cao, J.J., Wu, M., Gao, H. 2012. CCAAT/enhancer-binding protein ¿ is a critical regulator of IL-1ß-induced IL-6 production in alveolar epithelial cells. Proceedings of the National Academy of Sciences. 7(4):e35492. doi:10.1371/journal.pone.0035492.
Selenium deficiency decreases antioxidative capacity and is detrimental to bone microarchitecture in mice     Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Gregoire, B.R., Zeng, H. 2012. Selenium deficiency decreases antioxidative capacity and is detrimental to bone microarchitecture in mice. Journal of Nutrition. 142:1526-1531.
Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet-induced obese rats     Reprint Icon - (Peer Reviewed Journal)
Shen, C., Cao, J.J., Dagda, R., Chanjaplammootil, S., Lu, C., Chyu, M., Gao, W., Wang, J., Yeh, J.K. 2012. Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet-induced obese rats. Nutrition Research. 32:448-457.
Alpha-1 antitrypsin reduces ovariectomy-induced bone loss in mice     Reprint Icon - (Peer Reviewed Journal)
Cao, J.J., Gregoire, B.R., Song, S. 2012. Alpha-1 antitrypsin reduces ovariectomy-induced bone loss in mice. Annals of the New York Academy of Sciences. doi: 10.111/j.1749-6632.2011.06370.x.
A high protein diet upregulated whole-body protein turnover during energy deficit - (Abstract Only)
Margolis, L.M., Cao, J.J., Sauter, E.R., Whigham Grendell, L.D., Mcclung, J.P., Combs, G.F., Young, A.J., Pasiakos, S.M. 2012. A high protein diet upregulated whole-body protein turnover during energy deficit. Federation of American Societies for Experimental Biology Conference. 26:1013.3.
Increased adiposity induced by high dietary butter oil increases vertebrae trabecular structural indices in rats - (Abstract Only)
Nielsen, F.H. 2012. Increased adiposity induced by high dietary butter oil increases vertebrae trabecular structural indices in rats. Experimental Biology. 26:265.1.
An essential role for the Stat3 in regulating IgG immune complex-induced pulmonary inflammation     Reprint Icon - (Peer Reviewed Journal)
Tang, H., Yan, C., Cao, J.J., Sarma, J.V., Haura, E.B., Wu, M., Gao, H. 2011. An essential role for the Stat3 in regulating IgG immune complex-induced pulmonary inflammation. Journal of Federation of American Societies for Experimental Biology. 25:4292-4300.
Growing evidence for human health benefits of boron     Reprint Icon - (Review Article)
Nielsen, F.H., Meacham, S. 2011. Growing evidence for human health benefits of boron. Evidence-based Complementary and Alternative Medicine. 16(3) 169-180.
Effects of obesity on bone metabolism     Reprint Icon - (Review Article)
Cao, J.J. 2011. Effects of obesity on bone metabolism. Journal of Orthopaedic Surgery and Research. doi:10.1186/1749-799X-6-30.
Green tea and bone health     Reprint Icon - (Book / Chapter)
Shen, C., Yeh, J.K., Cao, J.J., Chyu, M., Wang, J. 2012. Green tea and bone health. Pharmacological Research. 64(2):155-161.
Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats     Reprint Icon - (Peer Reviewed Journal)
Shen, C., Cao, J.J., Dagda, R.Y., Tenner, T.E., Chyu, M., Yeh, J.K. 2011. Supplementation of green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats. Calcified Tissue International. 88(6):455-463.
Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats     Reprint Icon - (Peer Reviewed Journal)
Shen, C., Samathanam, C., Tatum, O.L., Graham, S., Tubb, C., Cao, J.J., Dunn, D.M., Wang, J. 2011. Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats. Inflammation Research. 60(7):665-672.
Zinc deficiency increases miR-34a expression in mice - (Abstract Only)
Liuzzi, J.P., Valencia, K., Cao, J.J., Gonzales, A. 2011. Zinc deficiency increases miR-34a expression in mice. Federation of American Societies for Experimental Biology Conference. 25:977.1.
Plasma C-reactive protein (CRP), an indicator of inflammation, is decreased but plasma lipids are increased, especially with magnesium (Mg) deprivation, in rats made obese by high dietary butter oil - (Abstract Only)
Nielsen, F.H. 2011. Plasma C-reactive protein (CRP), an indicator of inflammation, is decreased but plasma lipids are increased, especially with magnesium (Mg) deprivation, in rats made obese by high dietary butter oil. Federation of American Societies for Experimental Biology Conference. 25:109.8.
Dietary protein, calcium metabolism and bone health in humans - (Abstract Only)
Cao, J.J. 2010. Dietary protein, calcium metabolism and bone health in humans. International Conference on Osteoporosis. Abstract No. HT6. p.75.
Suppressor of cytokine signaling 3 inhibits LPS-induced IL-6 expression in osteoblasts by suppressing CCAAT/enhancer-binding protein ß activity     Reprint Icon - (Peer Reviewed Journal)
Yan, C., Cao, J.J., Wu, M., Jiang, T., Yoshimura, A., Gao, H., Zhang, W. 2010. Suppressor of cytokine signaling 3 inhibits LPS-induced IL-6 expression in osteoblasts by suppressing CCAAT/enhancer-binding protein ß activity. Journal of Biological Chemistry. 285(48):37227-37239.
Acid diet (high meat protein) effects on calcium metabolism and bone health     Reprint Icon - (Review Article)
Cao, J.J., Nielsen, F.H. 2010. Acid diet (high meat protein) effects on calcium metabolism and bone health. Current Opinion in Clinical Nutrition and Metabolic Care. 13(6):698-702.
Last Modified: 9/22/2014
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