1a.Objectives (from AD-416)
To determine the influence of cranberry on risk factors for cardiovascular disease. Objective 2 “Determine the ability of plant-based dietary components to reduce oxidative stress, inflammation, DNA damage, glucoregulation, and blood pressure, and define the inter-individual variation in these responses as well as the genetic basis for the variation.”
1b.Approach (from AD-416)
ARS will conduct a randomized clinical trial to investigate the effect of cranberry polyphenols on risk factors (such as inflammatory markers, lipids, lipoproteins, blood pressure) for cardiovascular disease. A cranberry extract will be used in order to conduct this study to ensure that the study is double blinded.
This is a project to assess the impact of cranberry juice of cardiovascular disease risk factors. A human feeding study has been completed in which 57 volunteers consumed cranberry juice or a placebo beverage daily for 8 weeks. Blood and urine samples were collected for analysis of a variety of health markers, such as cholesterol levels. Assays are being completed but results cannot be shared in this report. These results will provide information about how to improve health through an important agricultural product. Activities and progress of this Agreement were monitored through site visits, conference calls, and email correspondence.