2011 Annual Report 1a.Objectives (from AD-416) 1. Identify mechanisms that mediate anti-diabetic effects of serviceberry extracts. 2. Isolate and identify the anti-diabetic constituent(s) from serviceberry. 3. Develop a robust micropropagation system for rapid germplasm multiplication, maintenance and storage. 4. Develop efficient organic production systems for serviceberry cultivation. 1b.Approach (from AD-416) ARS contact scientist will identify anti-diabetic constituents from serviceberry through activity-guided fractionation using an assay that will be conducted at Auburn University, another collaborator in this project. ARS scientist will use various spectroscopic methods to identify the anti-diabetic constituent(s). 3.Progress Report Serviceberry leaves have been extracted and fractionated following bioassay-guided fractionation. Subfractions have been tested for anti-diabetic activity. An active sub-fraction has been obtained. Isolation of the active anti-diabetic compound is currently being performed. Information concerning this research was monitored through emails and teleconferences.