Project Number: 1245-32000-098-02
Project Type: Reimbursable

Start Date: Jan 01, 2010
End Date: Dec 31, 2013

Objective:
The specific objectives will be 1) Identify differentially expressed (DE) genes in blood in response to PRRSV infection; 2) Determine putative gene sets and pathways that predict a pig’s ability to clear PRRSV infection and maintain weight gain; and 3) Validate utility of gene sets and pathways for prediction of responsiveness to PRRSV infections in multiple populations.

Approach:
The proposed studies will identify functional genomic determinants, and potential “classifier genes” that predict resistance/susceptibility of commercial U.S. swine to PRRSV infection and associated growth losses. Such gene-specific information will directly complement the genetic variation and QTL mapping data being developed in the PHGC, to provide an integrated view of the molecular genetic architecture of PRRSV resistance. All information will be disseminated to swine researchers and breeders, as well as genetics companies and genotyping services so that these recommended genes can be targeted in future breeding programs to increase resistance to PRRS, the most economically important disease affecting the U.S. pork industry.