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United States Department of Agriculture

Agricultural Research Service

Research Project: Immunological Control of Rift Valley Fever Virus (Rvfv) in African Ruminants

Location: Arthropod-Borne Animal Diseases Research

Project Number: 5430-32000-005-08
Project Type: Specific Cooperative Agreement

Start Date: Sep 30, 2009
End Date: Sep 29, 2014

Objective:
Conduct clinical studies with the next generation of RVFV vaccines to determine their efficacy for disease control in Kenya.

Approach:
Implement clinical challenge studies to evaluate the ability of available RVFV vaccines to stop viremia post challenge thus block viral transmission to the mosquito host. The initial portion of the project is to develop vaccination dose strategies by evaluating the host immune response to vaccination in relevant domestic African ruminant species. Project also requires the development of a challenge model in relevant domestic African ruminant species to evaluate the ability of RVFV vaccine(s) to prevent transmission to a relevant mosquito vector. Preferably, the challenge model will account for commonly occurring natural challenges by using mosquito transmission. The vaccine challenge model will require a sub agreement with the Onderstepoort Veterinary Institute due to lack of Animal Biosafety level 3 (ABSL-3) facilities in Kenya.

Last Modified: 4/16/2014
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