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United States Department of Agriculture

Agricultural Research Service

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Research Project: Applying Epidemiological Models to Understanding the Emergence of New Fmd Virus Antigenic and Genetic Variants

Location: Foreign Animal Disease Research

2010 Annual Report

1a.Objectives (from AD-416)
The Foot-and-Mouth Disease (FMD) lab within the CADMS (Center for Animal Disease Modelling Systems) is located at the University of California, Davis and along with ARS, is a member of the Global Foot-and-Mouth Disease Research Alliance (GFRA). CADMS is currently compiling extensive global disease surveillance data and is developing a global web-based disease surveillance system, which has resulted in the FMD BioPortal, a publically-available site. ARS is interested in leveraging CADMS capabilities with our offshore research efforts in countries like India, Pakistan as well as future research projects in South East Asia. The objectives of this collaboration are: 1. To expand the UC Davis FMD BioPortal and to provide epidemiological information to ARS, PIADC to aid in current offshore FMD research projects in India, Pakistan and other future related projects. 2. Incorporate FMD virus sequences and epidemiological data provided from ARS collaborators in India, Pakistan and other future collaborators in South East Asia, into the BioPortal system. 3. Identify relationships between the variation in number of different nucleotides within the P1 gene of FMD virus provided by ARS collaborators in India, Pakistan and other future collaborators in South East Asia or ARS, PIADC and features of the host population that were associated with changes in the virus sequences.

1b.Approach (from AD-416)
1. ARS, PIADC will provide sequencing data and analysis of field isolates of viruses made available through UC Davis. This data will be incorporated into the BioPortal. 2. UC Davis will provide epidemiological expertise to ARS, PIADC to further basic and applied research. 3. Epidemiological information and sequences provided by ARS, PIADC and ICAR will be incorporated to the FMD BioPortal and will be made available to research partners and the general public in near real time. 4. Data will be used to quantify the relation between nucleotide variation in the P1 sequences of the viruses provided by ICAR and ARS, PIADC and the epidemiological factors hypothesized to be associated with such variation.

3.Progress Report

The objective of this collaborative research project is to use the UC Davis Disease BioPortal (DBP), which is a web-based disease surveillance system to support foreign animal disease research with the ultimate goal of preventing and controlling Foot-and-Mouth Disease (FMD) and other vesicular diseases. The following accomplishments were made in FY 2010: 1. Provision of epidemiological expertise for the temporal, spatial, and phylognetic assessment of full-sequenced serotype A FMD viruses from Argentina, 2001. The full-length genetic sequence of fourteen FMDV samples were determined and the genetic divergences between the earliest and last isolates computed. Results indicated that the time between isolates influenced the rate of genetic change so that the rate of change decreased as time between isolates increased. 2. The temporal and spatial distribution and reproductive ration of VS outbreaks in Mexico 2008 were quantified in collaboration with the Emerging Animal Disease Commission, Mexico. 3. Factors associated with transmission of serotype A FMD virus from Argentina, 2001. FMD transmission studies were conducted on herds affected by FMD in Argentina in 2001. The disease propagation rate resulted in on average 2 infected animals per previously infected animal, which is compatible with a propagative epidemic. The following accomplishments occurred over the life of this project: 1. Critical aspects of the epidemiology of VSV and FMD have been elucidated, including the epidemiological assessment of the VS epidemic that affected Mexico in 2008, 2. Preliminary analysis of factors associated with FMDV evolution in Argentina in 2001. In FY 2011 we anticipate: 1. Complete the quantification of reproductive ratio of FMD during the epidemic that affected Argentina in 2001 and its association with demographic factors, 2. Complete the phylogenetic and epidemiological analysis of FMDV evolution in Argentina 2001, 3. Investigate the epidemiology of FMD in Nigeria, 4. Produce a report for the Global Foot-and-Mouth Disease Research Alliance (GFRA) on the characteristics of surveillance system used at international or global scales for infectious animal diseases. The following publication and eight abstracts detail the work under this collaborative research project: Arroyo, M., et al., “Space-time analysis and herd reproductive ratio of vesicular stomatitis in Mexico in 2008”, American Journal of Veterinary Research (accepted). This research project was monitored through email and telephone exchange and site visits to ARS, PIADC.

Last Modified: 4/20/2014
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