Start Date: Sep 25, 2009
End Date: Sep 24, 2014
This research will address the prevention of childhood/adult obesity, which involves food choices/patterns, physical activity and energy balance, metabolism/physiology, genotype/phenotypic expression, food access/composition, attitudes/traditions, and processes that can lead to diabetes, cancer, heart disease and osteoarthritis. This demands innovative, translational research to generate new knowledge and improve the evidence base for national nutrition/health/food policy. This will be accomplished in this project by addressing the following areas: 1. U.S. Dietary Guidelines Adherence and Healthy Body Weight. Research to identify barriers/ facilitators to adhering to the Dietary Guidelines. 2. Biology of Obesity Prevention. Research on metabolism/physiology affected by diet/physical activity in maintaining healthy body weight; use of “omics” tools to understand individuals’ responses to interventions and propensities to gain weight. 3. Food Factors in Maintaining Health & Healthy Body Weight. Research examining the effects of food antioxidants on metabolic responses to exercise. 4. Body Weight and Bone Health. Research on the roles of adiposity and body weight on inflammation and bone health. 5. Diet and Physical Activity in Mitigating Obesity-Promoted Carcinogenesis. Research on the effects of adiposity on the metabolism and anticarcinogenic mechanisms of selenium.