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United States Department of Agriculture

Agricultural Research Service

Research Project: NUTRITIONAL DETERMINANTS OF NON-ALCOHOLIC STEATOHEPATITIS IN HEPATIC CARCINOGENESIS

Location: Human Nutrition Research Center on Aging

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Development of ferret as a human lung cancer model by injecting4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - (Peer Reviewed Journal)
Aizawa, K., Liu, C., Veeramachaneni, S., Hu, K., Smith, D.E., Wang, X. 2013. Development of ferret as a human lung cancer model by injecting4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Lung Cancer. doi:10.1016/j.lungcan.2013.09.012.
Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice - (Peer Reviewed Journal)
Ip, B.C., Hu, K., Liu, C., Smith, D.E., Obin, M.S., Ausman, L.M., Wang, X. 2013. Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice. Cancer Prevention Research. 6(12):1304-1316. DOI:10.1158/1940-6207. CAPR-13-0178.
Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats - (Peer Reviewed Journal)
Nascimento, A.F., Ip, B.C., Luvizotto, R.A., Seitz, H.K., Wang, X. 2013. Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats. Hepatobiliary Surgery and Nutrition. 2013;2(5):252-259.
Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions - (Peer Reviewed Journal)
Melendez-Martinez, A.J., Nascimento, A.F., Wang, Y., Liu, C., Mao, Y., Wang, X. 2013. Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions. Hepatobiliary Surgery and Nutrition. 2(4):198-208.
Beta-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice - (Peer Reviewed Journal)
Iskandar, A., Liu, C., Smith, D.E., Hu, K., Choi, S., Ausman, L.M., Wang, X. 2013. Beta-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice. Cancer Prevention Research. 6(4):309-320.
Cytochrome P4502E1 inhibitor, chlormethiazole, decreases lipopolysaccharide-induced inflammation in rat Kupffer cells with ethanol treatment - (Peer Reviewed Journal)
Ye, Q., Wang, X., Wang, Q., Xia, M., Zhu, Y., Lian, F., Ling, W. 2013. Cytochrome P4502E1 inhibitor, chlormethiazole, decreases lipopolysaccharide-induced inflammation in rat Kupffer cells with ethanol treatment. Hepatology Research. 43:1-9.
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats - (Peer Reviewed Journal)
Ye, Q., Lian, F., Chavez, P.R., Chung, J., Qin, H., Sitz, H.K., Wang, X. 2012. Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. Hepatobiliary Surgery and Nutrition. 1(1):5-18.
A simple HPLC method for the comprehensive analysis of cis/trans (Z/E) geometrical isomers of carotenoids for nutritional studies - (Peer Reviewed Journal)
Melendez-Martinez, A.J., Stinco, C.M., Liu, C., Wang, X. 2013. A simple HPLC method for the comprehensive analysis of cis/trans (Z/E) geometrical isomers of carotenoids for nutritional studies. Food Chemistry. 138(2-3):1341-1350.
Concomitant consumption of lycopene and fish oil inhibits tumor growth and progression in a mouse xenograft model of colon cancer - (Peer Reviewed Journal)
Tang, F., Pai, M., Kuo, Y., Wang, X. 2012. Concomitant consumption of lycopene and fish oil inhibits tumor growth and progression in a mouse xenograft model of colon cancer. Molecular Nutrition and Food Research. 56(10):1520-1531.
Apo-10'-lycopenoic acid, a lycopene 1 metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice - (Peer Reviewed Journal)
Chung, J., Koo, K., Lian, F., Hu, K., Ernst, H., Wang, X. 2012. Apo-10'-lycopenoic acid, a lycopene 1 metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice. Journal of Nutrition. 142(3):405-410.
Consumption of lycopene inhibits the growth and progression of colon cancer in a mouse xenograft model - (Peer Reviewed Journal)
Tang, F., Pai, M., Wang, X. 2011. Consumption of lycopene inhibits the growth and progression of colon cancer in a mouse xenograft model. Journal of Agricultural and Food Chemistry. 59(16):9011-9021.
Combined alpha-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets - (Peer Reviewed Journal)
Kim, Y., Chongviriyaphana, N., Liu, C., Russel, R., Wang, X. 2012. Combined alpha-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets. Lung Cancer. 75:15-23.
Long term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats - (Peer Reviewed Journal)
Chavez, P., Chung, J., Liu, C., Paiva, S., Seitz, H., Wang, X., Lian, F. 2011. Long term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats. Journal of Nutrition. 141(6):1049-1055 PMID 21490289.
Beta-Cryptoxanthin supplementation prevents cigarette smoke-induced lung inflammation, oxidative damage and squamous metaplasia in ferrets - (Peer Reviewed Journal)
Liu, C., Bronson, R.T., Russell, R., Wang, X. 2011. Beta-Cryptoxanthin supplementation prevents cigarette smoke-induced lung inflammation, oxidative damage and squamous metaplasia in ferrets. Cancer Prevention Research. PMID:21421799.
Enzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein, zeaxanthin and b-cryptoxanthin by ferret carotene-9, 10-monooxygenase - (Peer Reviewed Journal)
Mein, J., Dolnikowski, G., Hansgeorg, E., Russel, R., Wang, X. 2011. Enzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein, zeaxanthin and b-cryptoxanthin by ferret carotene-9, 10-monooxygenase. Archives Of Biochemistry and Biophysics. 506:109-121 PMID 21081106.
Chronic alcohol intake up-regulates hepatic expressions of carotenoid cleavage enzymes and peroxisomal proliferator-activated receptors in rats - (Peer Reviewed Journal)
Luvizotto, R., Nascimento, A., Veeramachnei, S., Liu, C., Wang, X. 2010. Chronic alcohol intake up-regulates hepatic expressions of carotenoid cleavage enzymes and peroxisomal proliferator-activated receptors in rats. Journal of Nutrition. 140(10):1808-1814. PMID 20702748.
Cyanidin-3-O-beta-glucoside inhibits LPS-induced expression of inflammatory mediators through decreasing IkBa Phosphorylation in THP-1 Cells - (Peer Reviewed Journal)
Zhang, Y., Lian, F., Zhu, Y., Xia, M., Wang, Q., Ling, W., Wang, X. 2010. Cyanidin-3-O-beta-glucoside inhibits LPS-induced expression of inflammatory mediators through decreasing IkBa Phosphorylation in THP-1 Cells. Inflammation Research. 59(9):723-730.
Biological activities of carotenoid metabolites - (Book / Chapter)
Wang, X. 2009. Biological activities of carotenoid metabolites. In: Britton, A., Jensen, B., Pfander, D., editors. Carotenoids. 5th edition. Basel, Switzerland: Verlag Press. p.383-408.
Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine initiated early hepatocarcinogenesis in rats - (Peer Reviewed Journal)
Wang, Y., Ausman, L.M., Greenberg, A.S., Russell, R.M., Wang, X. 2009. Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine initiated early hepatocarcinogenesis in rats. International Journal of Cancer. 124(3):540-546.
Oxidative metabolites of lycopene and their biological functions - (Book / Chapter)
Mein, J., Wang, X. 2009. Oxidative metabolites of lycopene and their biological functions. In: Landrum, M., editor. Carotenoids. New York, NY: Taylor and Francis. p.417-436.
Last Modified: 8/19/2014
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