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United States Department of Agriculture

Agricultural Research Service

Research Project: NUTRITION, PHYSICAL ACTIVITY AND SARCOPENIA IN THE ELDERLY

Location: Human Nutrition Research Center on Aging

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling - (Peer Reviewed Journal)
Rivas, D.A., Lessard, S.J., Rice, N.P., Lustgarten, M.S., So, K., Goodyear, L.J., Parnell, L.D., Fielding, R.A. 2014. Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling. Journal of Federation of American Societies for Experimental Biology. doi: 10.1096/fj.14-254490.
The Lifestyle Interventions and Independence for Elders (LIFE) study, randomized trial of physical activity: Effect on the prevention of major mobility disability - (Peer Reviewed Journal)
Pahor, M., Guralnik, J.M., Ambrosius, W.T., Blair, S., Bonds, D.E., Church, T.S., Espeland, M.A., Fielding, R.A., Gill, T.M., Groessl, E.J., King, A.C., Kritchevsky, S.B., Manini, T.M., Mcdermott, M.M., Miller, M.E., Newman, A.B., Rejeski, J.W., Romashkan, S., Sink, K.M., Williamson, J.D. 2014. The Lifestyle Interventions and Independence for Elders (LIFE) study, randomized trial of physical activity: Effect on the prevention of major mobility disability. Journal of the American Medical Association. 311(23):2387-2396.
Does neuromuscular activation capability explain mobility function among older men and women? - (Peer Reviewed Journal)
(24-Mar-14)
Does quadriceps neuromuscular activation capability explain mobility function among older men and women? - (Peer Reviewed Journal)
Clark, D.J., Reid, K.F., Patten, C., Phillips, E.M., Ring, S.A., Wu, S.S., Fielding, R.A. 2014. Does quadriceps neuromuscular activation capability explain mobility function among older men and women?. Experimental Gerontology. 55:49-53.
Serum Glycine Is Associated with Regional Body Fat and Insulin Resistance in Functionally-Limited Older Adults - (Peer Reviewed Journal)
Lustgarten, M.S., Price, L., Phillips, E.M., Fielding, R.A. 2013. Serum Glycine Is Associated with Regional Body Fat and Insulin Resistance in Functionally-Limited Older Adults. PLoS One. 8(12):e84034. DOI: 10.1371/journal.pone.0084034.
Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study - (Peer Reviewed Journal)
Mcdermott, M.M., Applegate, W.B., Bonds, D.E., Buford, T.W., Church, T., Espeland, M.A., Gill, T.M., Guralnik, J.M., Haskell, W., Lovato, L.C., Pahor, M., Pepine, C.J., Reid, K.F., Newman, A. 2013. Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. Journal of the American Heart Association. 2(6):e000257. DOI: 10.1161/JAHA.113.000257.
Longitudinal decline of lower extremity muscle power in healthy and mobility-limited older adults: influence of muscle mass, strength, composition, neuromuscular activation and single fiber contractile properties - (Peer Reviewed Journal)
Reid, K.F., Pasha, E., Doros, G., Clark, D.J., Patten, C., Phillips, E.M., Frontera, W.R., Fielding, R.A. 2014. Longitudinal decline of lower extremity muscle power in healthy and mobility-limited older adults: influence of muscle mass, strength, composition, neuromuscular activation and single fiber contractile properties. European Journal of Applied Physiology. 114:29-39. DOI:10.1007/s00421-013-2728-2.
Protein nutrition mediates lean body mass homeostasis in the aging warfighter1–3 - (Review Article)
Fielding, R.A. 2013. Protein nutrition mediates lean body mass homeostasis in the aging warfighter1–3. Journal of Nutrition. 143(11):1857S-1861S.
The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P) - (Peer Reviewed Journal)
Liu, C.K., Leng, X.I., Kritchevsky, S.B., Ding, J., Earnest, C.P., Ferrucci, L., Goodpaster, B.H., Guralnik, J.M., Lenchick, L., Pahor, M., Fielding, R.A. 2014. The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). Journal of Nutrition Health and Aging. 18(1):59-64.
Lifestyle interventions and independence for elders study: Recruitment and baseline characteristics - (Peer Reviewed Journal)
Marsh, A.P., Lovato, L.C., Glynn, N.W., Kennedy, K., Castro, C., Domanchuk, K., Mcdavitt, E., Rodarte, R., Marsiske, M., Mcgloin, J., Groessl, E.J., Pahor, M., Guralnik, J.M. 2013. Lifestyle interventions and independence for elders study: Recruitment and baseline characteristics. Journal of Gerontology Medical Science. 68(12):1549-1558.
Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors - (Peer Reviewed Journal)
Espeland, M.A., Katula, J.A., Rushing, J., Kramer, A., Jennings, J., Sink, K.M., Nadkarni, N.K., Reid, K.F., Castro, C.M., Church, T., Kerwin, D.R., Williamson, J.D., Marttoli, R.A., Rushing, S., Marsiske, M., Rapp, S.R. 2013. Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors. International Journal of Geriatric Psychiatry. DOI: 10.1002/gps.3949.
Neuromuscular determinants of maximum walking speed in well-functioning older adults - (Peer Reviewed Journal)
Clark, D., Manini, T.M., Fielding, R.A., Patten, C. 2013. Neuromuscular determinants of maximum walking speed in well-functioning older adults. Experimental Gerontology. 48(3):358-363.
Identification of serum analytes and metabolites associated with aerobic capacity - (Peer Reviewed Journal)
Lustgarten, M.S., Price, L., Logvinenko, T., Hatzis, C., Padukone, N., Reo, N.V., Phillips, E.M., Kirn, D., Mills, J., Fielding, R.A. 2013. Identification of serum analytes and metabolites associated with aerobic capacity. European Journal of Applied Physiology. 113(5):1311-1320.
Relation of pulse pressure to long-distance gait speed in community-dwelling older adults: Findings from the LIFE-P study - (Peer Reviewed Journal)
Heffernan, K.S., Manini, T., Blair, S., Hsu, F., Nicklas, B., Kritchevsky, S., Newman, A.B., Sutton-Tyrrell, K., Church, T., Haskell, W., Karas, R., Kuvin, J., Fielding, R.A. 2012. Relation of pulse pressure to long-distance gait speed in community-dwelling older adults: Findings from the LIFE-P study. PLoS One. 7(11):e49544.
Increased ceramide content and NFkB signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males - (Peer Reviewed Journal)
Rivas, D.A., Morris, E.P., Haran, P.H., Pasha, E.P., Morais, M.V., Dolnikowski, G., Phillips, E.M., Fielding, R.A. 2012. Increased ceramide content and NFkB signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males. Journal of Applied Physiology. 113(11):1726-1736.
Efficacy of whey protein supplementation on resistance exercise-induced changes in muscle strength, lean mass, and function in mobility-limited older adults - (Peer Reviewed Journal)
Chale, A., Cloutier, G., Hau, C., Phillips, E., Dallal, G., Fielding, R. 2013. Efficacy of whey protein supplementation on resistance exercise-induced changes in muscle strength, lean mass, and function in mobility-limited older adults. Journals of Gerontology. 68(6):682-690.
Systemic vascular function is associated with muscular power in adults - (Peer Reviewed Journal)
Heffernan, K.S., Chale, A., Hau, C., Cloutier, G.J., Phillips, E.M., Warner, P., Nickerson, H., Reid, K.F., Kuvin, J.T., Fielding, R.A. 2012. Systemic vascular function is associated with muscular power in adults. Journal of Aging Research. DOI: 10.1155/386387.
Biomarkers of sarcopenia in clincal trials recommendations from the international working group on sarcopenia - (Review Article)
Cesari, M., Fielding, R., Pahor, M., Goodpaster, B., Hellerstein, M., Abellan Van Kan, G., Anker, S.D., Rutkove, S., Vrijbloed, J., Isaac, M., Rolland, Y., M'Rini, C., Aubertin-Leheudre, M., Cedarbaum, J.M., Zamboni, G., Sieber, C., Laurent, D., Evans, W.J., Roubenoff, R., Morley, J.E., Vellas, B. 2012. Biomarkers of sarcopenia in clincal trials recommendations from the international working group on sarcopenia. Journal of Cachexia, Sarcopenia and Muscle. 3(3):181-190.
The specific contributions of force and velocity to muscle power in older adults - (Peer Reviewed Journal)
Pojednic, R., Clark, D., Patten, C., Reid, K., Phillips, E., Fielding, R. 2012. The specific contributions of force and velocity to muscle power in older adults. Journal of Aging and Physical Activity. 47(8):608-613.
Low bone mass in behaviorally HIV-infected young men on antiretroviral therapy: adolescent trials network (ATN) study 021B - (Peer Reviewed Journal)
Mulligan, K., Harris, D., Emmanuel, P., Fielding, R., Worrell, C., Kapogiannis, B., Monte, D., Sleasman, J., Wilson, C., Aldrovandi, G. 2012. Low bone mass in behaviorally HIV-infected young men on antiretroviral therapy: adolescent trials network (ATN) study 021B. Clinical Infectious Diseases. 55(3):461-468.
Role and potential mechanisms of anabolic resistance in sarcopenia - (Review Article)
Haran, P., Rivas, D., Fielding, R. 2012. Role and potential mechanisms of anabolic resistance in sarcopenia. Journal of Cachexia, Sarcopenia and Muscle. DOI: 1007/s13539-012-0068-4.
Muscle power failure in mobility-limited adults: preserved single muscle fibre function despite reduced whole muscle size, quality and neuromuscular activiation - (Peer Reviewed Journal)
Reid, K., Doros, G., Clark, D., Patten, C., Carabello, R., Cloutier, G., Phillips, E., Krivickas, L., Frontera, W., Fielding, R. 2011. Muscle power failure in mobility-limited adults: preserved single muscle fibre function despite reduced whole muscle size, quality and neuromuscular activiation. European Journal of Applied Physiology. 112(6):2289-2301. PMID:22005960.
Skeletal muscle power: a critical determinant of physical functioning in older adults - (Review Article)
Reid, K.F., Fielding, R.A. 2012. Skeletal muscle power: a critical determinant of physical functioning in older adults. Medicine and Science in Sports and Exercise. 40(1):4-12.
Body fat distribution in perinatally HIV-infected and HIV-exposed but uninfected children in the era of highly active antiretroviral therapy: outcomes from the Pediatric HIV/AIDS Cohort Study - (Peer Reviewed Journal)
Jacobson, D., Patel, K., Siberry, G., Van Dyke, R., Dimeglio, L., Geffner, M., Chen, J., Mcfarland, E., Borkowsky, W., Silio, M., Fielding, R., Siminski, S., Miller, T. 2011. Body fat distribution in perinatally HIV-infected and HIV-exposed but uninfected children in the era of highly active antiretroviral therapy: outcomes from the Pediatric HIV/AIDS Cohort Study. American Journal of Clinical Nutrition. 92(6):1485-1495.
Muscle strength and BMI as predictors of major mobility disability in the lifestyle interventions and independence for elders pilot (LIFE-P) - (Peer Reviewed Journal)
Marsh, A., Rejeski, W., Espeland, M., Miller, M., Church, T., Fielding, R., Gill, T., Guralnik, J., Newman, A., Pahor, M. 2011. Muscle strength and BMI as predictors of major mobility disability in the lifestyle interventions and independence for elders pilot (LIFE-P). Journal of Gerontology Medical Science. 66A(12):1376-1383 PMID: 21975090.
Increases in muscle strength and balance using a resistance training program administered via a telecommunications system in older adults - (Peer Reviewed Journal)
Sparrow, D., Gottlieb, D., Demolles, D., Fielding, R. 2011. Increases in muscle strength and balance using a resistance training program administered via a telecommunications system in older adults. Journal of Gerontology Medical Science. DOI: 10.1093/gerona/girl38.
The lifestyle interventions and independence for elders study: design and methods - (Peer Reviewed Journal)
Fielding, R., Rejeski, W., Blair, S., Church, T., Espeland, M., Gill, T., Guralnik, J., Hsu, F., Katula, J., King, A., Kritchevsky, S., Mcdermott, M., Miller, M., Nayfield, S., Newman, A., Williamson, J., Bonds, D., Romashkan, S., Hadley, E., Pahor, M. 2011. The lifestyle interventions and independence for elders study: design and methods. Journal of Gerontology Biological Science. DOI: 10.1093/gerona/girl123.
Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis - (Peer Reviewed Journal)
Pasiakos, S., Mcclung, H., Mcclung, J., Margolis, L., Andersen, N., Cloutier, G., Pikosky, M., Rood, J., Fielding, R., Young, A. 2011. Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis. American Society for Clinical Nutrition. DOI: 10.3945/ajcn.111.017061. PMID:21775557.
Sarcopenia: designing phase IIb trials: international working group on sarcopenia - (Review Article)
Chumlea, W.C., Cesari, M., Evans, W.J., Ferrucci, L., Fielding, R.A., Pahor, M., Studendski, S., Vellas, B. 2011. Sarcopenia: designing phase IIb trials: international working group on sarcopenia. Journal of Nutrition Health and Aging. 15(6):450-455.
Skeletal muscle - (Book / Chapter)
Rivas, D., Fielding, R. 2013. Skeletal muscle. In: Caballero, B., editor. Encyclopedia of Human Nutrition - 3rd Edition. Amsterdam: Adcademic Press. p. 193-199.
High protein diet maintains glucose production during exercise-induced energy deficit: a controlled trial - (Peer Reviewed Journal)
Smith, T.J., Schwartz, J., Montain, S.J., Rood, J., Pikosky, M.A., Castaneda-Sceppa, C., Glickman, E., Young, A.J. 2011. High protein diet maintains glucose production during exercise-induced energy deficit: a controlled trial. Nutrition and Metabolism. 8(1):26.
Lipogenic regulators are elevated with age and chronic overload in rat skeletal muscle - (Peer Reviewed Journal)
Rivas, D., Morris, E., Fielding, R. 2011. Lipogenic regulators are elevated with age and chronic overload in rat skeletal muscle. Acta Physiologica. 202(4):691-701.
A novel, non-invasive transdermal fluid sampling methodology: IGF-I measurement following exercise - (Peer Reviewed Journal)
Scofield, D.E., Mcclung, H.L., Mcclung, J.P., Kraemer, W., Rarick, K., Pierce, J.R., Cloutier, G., Fielding, R.A., Matheny, R.W., Young, A. 2011. A novel, non-invasive transdermal fluid sampling methodology: IGF-I measurement following exercise. American Journal of Physiology Regulatory Integrative and Comparative Physiology. 300(6):R1326-1332.
Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults - (Peer Reviewed Journal)
Choi, S., Lim, J., Nibaldi, E.G., Phillips, E.M., Frontera, W.R., Fielding, R.A., Widrick, J.J. 2012. Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults. Journal of the American Aging Association (AGE). 34(1):215-226.
Neuromuscular contributions to age-related weakness - (Review Article)
Clark, D.J., Fielding, R.A. 2012. Neuromuscular contributions to age-related weakness. Journal of Gerontology Medical Science. 67(1):41-47.
The impact of sarcopenia on the response to a physical activity intervention in older adults - (Abstract Only)
Liu, C., Leng, I., Kritchevsky, S., Ding, J., Earnest, C., Ferrucci, L., Goodpaster, B., Guralnik, J., Hsu, F., Lenchick, L., Fielding, R.A. 2011. The impact of sarcopenia on the response to a physical activity intervention in older adults. Journal of the American Geriatrics Society. Control ID: 1025329.
Exercise as an intervention for frailty - (Peer Reviewed Journal)
Fielding, R.A., Liu, C.K. 2011. Exercise as an intervention for frailty. Clinics in Geriatric Medicine. 27(1):101-110.
Assessment of analytical methods used to measure changes in body composition in the elderly and recommendations for their use in phase II clinical trials - (Peer Reviewed Journal)
Lustgarten, M., Fielding, R. 2011. Assessment of analytical methods used to measure changes in body composition in the elderly and recommendations for their use in phase II clinical trials. Journal of Nutrition Health and Aging. 15(5):368-375. PMID:21528163.
Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study - (Review Article)
Hsu, F., Rejeski, W., Ip, E.H., Katula, J.A., Fielding, R.A., Jette, A.M., Studenski, S.A., Blair, S., Miller, M.E. 2010. Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Health and Quality of Life Outcomes. 8:115.
Relationship between physical functioning and physical activity in the lifestyle interventions and independence for elders pilot - (Peer Reviewed Journal)
Chale-Rush, A., Guralnik, J.M., Walkup, M.P., Miller, M.E., Rejeski, W., Katula, J.A., King, A.C., Glynn, N.W., Manini, T.M., Blair, S.N., Fielding, R.A. 2010. Relationship between physical functioning and physical activity in the lifestyle interventions and independence for elders pilot. Journal of the American Geriatrics Society. 58(10):1918-1924.
Muscle performance and physical function are associated with voluntary rate of neuromuscular activation in older adults - (Peer Reviewed Journal)
Clark, D.J., Patten, C., Redi, K.F., Carabello, R.J., Fielding, R.A. 2011. Muscle performance and physical function are associated with voluntary rate of neuromuscular activation in older adults. Journal of the American Geriatrics Society. 58(1):1918-1924.
Molecular responses to moderate endurance exercise in skeletal muscle - (Peer Reviewed Journal)
Pasiakos, S.M., Mcclung, H.L., Mcclung, J.P., Urso, M.L., Cloutier, G.J., Fielding, R.A. 2010. Molecular responses to moderate endurance exercise in skeletal muscle. International Journal of Sport Nutrition and Exercise Metabolism. 20(4):282-290.
Habitual physical activity levels are associated with performance in measures of physical function and mobility in older men - (Peer Reviewed Journal)
Morie, M., Reid, K., Miciek, R., Lajevardi, N., Choong, K., Krasnoff, J., Storer, J., Fielding, R.A., Bhasin, S., Lebrassuer, N. 2010. Habitual physical activity levels are associated with performance in measures of physical function and mobility in older men. Journal of the American Geriatrics Society. 58(9):1727-1733.
Impaired voluntary neuromuscular activation limits muscle power in mobility-limited older adults - (Peer Reviewed Journal)
Clark, D.J., Patten, C., Reid, K.F., Carabello, R.J., Fielding, R.A. 2010. Impaired voluntary neuromuscular activation limits muscle power in mobility-limited older adults. Journals of Gerontology. 65(5):495-502.
N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone - (Peer Reviewed Journal)
Bhasin, S., He, J.E., Kawakubo, M., Schroeder, T.E., Yarasheski, K., Opiteck, G.J., Reicin, A., Chen, F., Lam, R., Tsou, J.A., Castaneda-Sceppa, C., Binder, E.F., Azen, S.P., Sattler, F.R. 2009. N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone. Journal of Clinical Endocrinology and Metabolism. 94(11):4224-4233.
Last Modified: 10/1/2014
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