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United States Department of Agriculture

Agricultural Research Service

Research Project: LIPOPROTEINS AND NUTRITION

Location: Human Nutrition Research Center on Aging

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Effects of atorvastatin on human c reactive protein metabolism - (Peer Reviewed Journal)
Thongtang, N., Diffenderfer, M.R., Ooi, E.M., Asztalos, B.F., Dolnikowski, G.G., Lamon-Fava, S., Schaefer, E.J. 2013. Effects of atorvastatin on human c reactive protein metabolism. Atherosclerosis. 226:466-470.
Nutrition in the prevention of Coronary Heart Disease and the management of lipoprotein disorders - (Book / Chapter)
Schaefer, E.J. 2012. Nutrition in the prevention of Coronary Heart Disease and the management of lipoprotein disorders. In: Ross, Catharine A. New York, NY. Lippincott Williams & Wilkins. Modern Nutrition in Health and Disease. 11th edition, p. 862-876.
Effects of therapeutic lifestyle change diets high and low in dietary fish-derived fatty acids on lipoprotein metabolism in middle-aged and elderly subjects - (Peer Reviewed Journal)
Ooi, E.M., Lichtenstein, A.H., Millar, J.S., Diffenderfer, M.R., Lamon-Fava, S., Rasmussen, H., Welty, F.K., Barrett, P.R., Schaefer, E.J. 2013. Effects of therapeutic lifestyle change diets high and low in dietary fish-derived fatty acids on lipoprotein metabolism in middle-aged and elderly subjects. Journal of Lipid Research. 53(9):1958-1967.
Effects of CETP inhibition on triglyceride-rich lipoprotein composition and apoB-48 metabolism - (Peer Reviewed Journal)
Diffenderfer, M., Brousseau, M., Millar, J., Barrett, P., Nartsupha, C., Schaefer, P., Wolfe, M., Dolnikowski, G., Rader, D., Schaefer, E. 2012. Effects of CETP inhibition on triglyceride-rich lipoprotein composition and apoB-48 metabolism. Journal of Lipid Research. 53(6):1190-1199.
Inflammation modulates human HDL composition and function in vivo - (Peer Reviewed Journal)
De La Llera Moya, M., Mcgillicuddy, F., Hinkle, C., Byrne, M., Joshi, M., Nguyen, V., Tabita-Martinez, J., Wolfe, M., Badellino, K., Pruscino, L., Mehta, N., Asztalos, B., Reilly, M. 2012. Inflammation modulates human HDL composition and function in vivo. Atherosclerosis. 222(2):390-394.
Plasma phosphatidylcholine concentrations of polyunsaturated fatty acids are differentially associated with hop bone mineral density and hip fracture in older adults: The Framingham Osteoporosis Study - (Peer Reviewed Journal)
Farina, E., Kiel, D., Roubenoff, R., Schaefer, E., Cupples, L., Tucker, K. 2012. Plasma phosphatidylcholine concentrations of polyunsaturated fatty acids are differentially associated with hop bone mineral density and hip fracture in older adults: The Framingham Osteoporosis Study. Journal of Bone and Mineral Research. 27(5):1222-1230.
Kif6, Lpa, Tas2r50, and Vamp8 Genetic Variation, Low Density Lipoprotein Cholesterol Lowering Response to Pravastatin, and Heart Disease Risk Reduction in the Elderly - (Peer Reviewed Journal)
Akao, H., Polisecki, E., Kajinami, K., Trompet, S., Robertson, M., Ford, I., Jukema, J., De Craen, A., Westendorp, R., Shepherd, J., Packard, C., Buckley, B., Schaefer, E. 2012. KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. Atherosclerosis. 220(2):456-462.
Regulation of the expression of key genes involved in HDL metabolism by unsaturated fatty acids - (Peer Reviewed Journal)
Kuang, Y., Paulson, K., Lichtenstein, A., Lamon-Fava, S. 2012. Regulation of the expression of key genes involved in HDL metabolism by unsaturated fatty acids. British Journal of Nutrition. DOI: 10.1017/S0007114511006854.
Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly - (Peer Reviewed Journal)
Akao, H., Polisecki, E., Kajinami, K., Trompet, S., Robertson, M., Ford, I., Jukema, J., De Craen, A., Westendorp, R., Shepherd, J., Packard, C., Buckleyi, B., Schaefer, E. 2012. Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly. Atherosclerosis. 220(2):413-417.
A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY -cholesterol - (Peer Reviewed Journal)
Sankaranarayanan, S., Kellner-Weibel, G., De La Llera-Moya, M., Phillios, M., Asztalos, B., Bittman, R., Rothblat, G. 2011. A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol. Journal of Lipid Research. 52(12):2332-2340.
Dysfunctional HDL containing L159R apoA-I leads to exacerbation of atherosclerosis in hyperlipidemic mice - (Peer Reviewed Journal)
Sorci-Thomas, M., Zabalawi, M., Bharadwaj, M., Wilhelm, A., Owen, J., Asztalos, B., Bhat, S., Thomas, M. 2012. Dysfunctional HDL containing L159R apoA-I leads to exacerbation of atherosclerosis in hyperlipidemic mice. Biochimica et Biophysica Acta. 1821(3):502-512.
Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: results from the Kyushu and Okinawa Populaiton Study (KOPS) - (Peer Reviewed Journal)
Furusyo, N., Koga, T., Ai, M., Otokozawa, S., Kohzuma, T., Ikezaki, H., Schaefer, E., Hayashi, J. 2011. Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: results from the Kyushu and Okinawa Populaiton Study (KOPS). Diabetologia. 54(12):3028-3036.
C-reactive protein and genetic variants and cognitive decline in old age: The PROSPER Study - (Peer Reviewed Journal)
Mooijaart, S., Sattar, N., Trompet, S., Polisecki, E., De Craen, A., Schaefer, E., Jahn, S., Van Himbergen, T., Welsh, P., Ford, I., Stott, D., Westendorp, R. 2011. C-reactive protein and genetic variants and cognitive decline in old age: The PROSPER Study. PLoS One. 6(9):e23890.
The effect of 17 beta-estradiol on cholesterol in human macrophages is influenced by the lipoprotein milieu - (Peer Reviewed Journal)
Corcoran, M., Lichtenstein, A., Meydani, M., Dillard, A., Schaefer, E., Lamon-Fava, S. 2011. The effect of 17 beta-estradiol on cholesterol in human macrophages is influenced by the lipoprotein milieu. Journal of Molecular Endocrinology. 47(1):109-117.
Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and Alzheimer disease - (Peer Reviewed Journal)
Van Himbergen, T., Beiser, A., Ai, M., Seshadri, S., Otokozawa, S., Au, R., Thongtang, N., Wolf, P., Schaefer, E. 2012. Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and Alzheimer disease. Archives of Neurology. DOI: 10.1001/archneurol.2011.670.
Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham Offspring Study - (Peer Reviewed Journal)
Ai, M., Otokozawa, S., Asztalos, B., White, C., Cupples, L., Nakajima, K., Lamon-Fava, S., Wilson, P., Matsuzawa, Y., Schaefer, E. 2011. Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham Offspring Study. Atherosclerosis. 217(2):543-548.
Metabolic and functional relevance of HDL subspecies - (Review Article)
Asztalos, B., Tani, M., Schaefer, E. 2011. Metabolic and functional relevance of HDL subspecies. Current Opinion in Lipidology. 22(3):176-185.
Lipoprotein(a) levels, apo(a) isoform size, and coronary heart disease risk in the Framingham Offspring Study - (Peer Reviewed Journal)
Lamon-Fava, S., Marcovina, S., Albers, J., Kennedy, H., Deluca, C., White, C., Cupples, L., Mcnamara, J., Seman, L., Bongard, V., Schaefer, E. 2011. Lipoprotein(a) levels, apo(a) isoform size, and coronary heart disease risk in the Framingham Offspring Study. Journal of Lipid Research. 52(6):1181-1187.
HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events - (Peer Reviewed Journal)
Rosenson, R., Brewer Jr., H., Chapman, M., Fazio, S., Hussain, M., Konush, A., Krauss, R., Otvos, J., Remaley, A., Schaefer, E. 2012. HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events. Clinical Chemistry. 57(3):392-410.
Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration - (Peer Reviewed Journal)
Sun, J., Strauch, C., Keenan, H., Monnier, V., Cavallerano, J., Doria, A., Asztalos, B., Aiello, L., Schaefer, E., King, G., Sell, D. 2011. Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration. Diabetes Care. 34(4):968-974.
High-density lipoprotein particles, coronary heart disease, and niacin - (Review Article)
Asztalos, B. 2010. High-density lipoprotein particles, coronary heart disease, and niacin. Clinical Lipidology. 4(5):405-410.
Effects of maximal atorvastatin and rosuvastatin treatment on markers of glucose homeostasis and inflammation - (Peer Reviewed Journal)
Thongtang, N., Ai, M., Otokozawa, S., Van Himbergen, T.M., Asztalos, B.F., Nakajima, K., Stein, E., Jones, P.H., Schaefer, E.J. 2011. Effects of maximal atorvastatin and rosuvastatin treatment on markers of glucose homeostasis and inflammation. American Journal of Cardiology. 107(3):387-392.
Sex hormone modulation of proinflammatory cytokine and CRP expression in macrophages from older men and postmenopausal women - (Peer Reviewed Journal)
Corcoran, M.P., Meydani, M., Lichtenstein, A.H., Schaefer, E.J., Dillard Hirschel, A., Lamon-Fava, S. 2010. Sex hormone modulation of proinflammatory cytokine and CRP expression in macrophages from older men and postmenopausal women. Journal of Endocrinology. 206(2):217-224.
Small dense low density lipoprotein cholesterol and coronary heart disease: results from the Framingham Offspring Study - (Peer Reviewed Journal)
Ai, M., Otokozawa, S., Asztalos, B.F., Ito, Y., Nakajima, K., White, C.C., Cupples, A.L., Wilson, P.W., Schaefer, E. 2010. Small dense low density lipoprotein cholesterol and coronary heart disease: results from the Framingham Offspring Study. Clinical Chemistry. 56(6):1-10.
Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly - (Peer Reviewed Journal)
Polisecki, E., Peter, I., Hegele, R., Robertson, M., Ford, I., Shepard, J., Packard, C., Jukema, W.J., De Craen, A., Westendorph, R.G., Buckley, B.M., Schaefer, E.J. 2010. Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly. Journal of Lipid Research. 51:1201-1207.
Northern light: a commentary on the 2009 Canadian Guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in adults - (Peer Reviewed Journal)
Schaefer, E. 2010. Northern light: a commentary on the 2009 Canadian Guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in adults. Clinical Chemistry. 56(4):502-504.
Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A treatment - (Peer Reviewed Journal)
Berson, E.L., Rosner, B., Sandberg, M.A., Weigel-Difranco, C., Brockhurst, R.J., Hayes, K.C., Johnson, E.J., Anderson, E.J., Johnson, C.A., Gaudio, A.R., Willett, W.C., Schaefer, E.J. 2010. Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A treatment. Archives of Ophthalmology. 128(4):403-411.
Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers - (Peer Reviewed Journal)
Van Himbergen, T.M., Matthan, N.R., Resteghini, N.A., Otokozawa, S., Jones, P., Schaefer, E. 2009. Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers. Journal of Lipid Research. 50:730-739.
Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach - (Peer Reviewed Journal)
Welsh, P., Polisecki, E., Robertson, M., Jahn, S., Buckley, B.M., De Crean, J., Ford, I., Jukema, J., Macfarlane, P.W., Packard, C.J., Stott, D.J., Westendrop, R.G., Sheperd, J., Hingorani, A.D., Smith, G., Schaefer, E.J., Sattar, N. 2009. Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. Journal of Clinical Endocrinology and Metabolism. 95(1):93-99.
Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway - (Peer Reviewed Journal)
Van Himbergen, T.M., Otokozawa, S., Matthan, N.R., Schaefer, E.J., Buchsbaum, A., Ai, M., Van Tits, L.J., De Graaf, J., Stalenhoef, A.F. 2010. Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. Arteriosclerosis Thrombosis and Vascular Biology. 30:113-120.
Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women - (Peer Reviewed Journal)
Lamon-Fava, S., Asztalos, B.F., Howard, T.D., Reboussin, D.M., Horvath, K., Schaefer, E.J., Herrington, D.M. 2009. Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women. Clinical Endocrinology. 72(2):169-175.
Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus - (Peer Reviewed Journal)
Ai, M., Otokozawa, S., Schaefer, E.J., Asztalos, B.F., Nakajima, K., Shrader, P., Kathiresan, S., Meigs, J.B., Williams, G., Nathan, D.M. 2009. Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus. Clinica Chimica Acta. 406:71-74.
Fasting and post-prandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjects - (Peer Reviewed Journal)
Otokozawa, S., Ai, M., Diffenderfer, M.R., Asztalos, B.F., Tanaka, A., Lamon-Fava, S., Schaefer, E. 2009. Fasting and post-prandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjects. Metabolism: Clinical and Experimental. 58:1536-1542.
Limitations of automated remnant lipoprotein cholesterol assay for diagnostic use - (Review Article)
Schaefer, E. 2009. Limitations of automated remnant lipoprotein cholesterol assay for diagnostic use. Clinical Chemistry. 55(11):2061-2062.
Dietary fructose and glucose differentially affect lipid and glucose homeostasis - (Peer Reviewed Journal)
Schaefer, E.J., Gleason, J.A., Dansinger, M.L. 2009. Dietary fructose and glucose differentially affect lipid and glucose homeostasis. Journal of Nutrition. 139(6):1257-1262.
Effects of cholesteryl ester transfer protein inhibition on apolipoprotein (apo) A-II-containing HDL subspecies and apoA-II metabolism - (Peer Reviewed Journal)
Brousseau, M.E., Millar, J.S., Diffenderfer, M.R., Nartsupha, C., Asztalos, B.F., Wolfe, M.L., Mancuso, J.P., Digenio, A.G., Rader, D.J., Schaefer, E.J. 2009. Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apoA-II metabolism. Journal of Lipid Research. 50(7):1456-1462.
Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levels - (Peer Reviewed Journal)
Otokozawa, S., Ai, M., Van Himbergen, T., Asztalos, B.F., Tanaka, A., Stein, E.A., Jones, P.H., Schaefer, E. 2009. Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levels. Atherosclerosis. 205(1):197-201.
Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically defined disease in post-menopausal women - (Peer Reviewed Journal)
Lamon-Fava, S., Herrington, D.M., Reboussin, D.M., Sherman, M., Horvath, K.V., Cupples, A.L., White, C., Demissie, S., Schaefer, E.J., Asztalos, B.F. 2008. Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically defined disease in post-menopausal women. Arteriosclerosis Thrombosis and Vascular Biology. 28(3):575-579.
Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER - (Peer Reviewed Journal)
Polisecki, E., Muallem, H., Maeda, N., Peter, I., Robertson, M., Mcmahon, A.D., Ford, I., Packard, C., Shepherd, J., Westendorp, R.G., De Crean, A.J., Buckley, B.M., Ordovas, J.M., Schaefer, E.J., Jukema, J. 2008. Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. Atherosclerosis. 200:109-114.
Genetic variation at the PCSK9 locus, low density lipoproteins, response to pravastatin and coronary heart disease: results from PROSPER - (Peer Reviewed Journal)
Polisecki, E., Peter, I., Robertson, M., Mcmahon, A.D., Ford, I., Packard, C., Shepherd, J., Jukema, J., Biauw, G.J., Westendrop, R.G., De Crean, A.J., Trompet, S., Buckley, B.M., Murphy, M.B., Ordovas, J.M., Schaefer, E.J. 2008. Genetic variation at the PCSK9 locus, low density lipoproteins, response to pravastatin and coronary heart disease: results from PROSPER. Atherosclerosis. 200:95-101.
Relative atherogenicity and predictive value of non-high-density lipoprotein cholesterol for coronary heart disease - (Peer Reviewed Journal)
Miller, M., Ginsberg, H.N., Schaefer, E.J. 2008. Relative atherogenicity and predictive value of non-high-density lipoprotein cholesterol for coronary heart disease. American Journal of Cardiology. 101(7):1003-1008.
Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency - (Peer Reviewed Journal)
Santos, R.D., Schaefer, E., Asztalos, B.F., Polisecki, E., Wang, J., Hegele, R.A., Martinez, L.R., Miname, M.H., Rochitte, C.E., Daluz, P.L., Maranhao, R.C. 2007. Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency. Journal of Lipid Research. 49:349-357.
Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism - (Peer Reviewed Journal)
Millar, J.S., Brousseau, M.E., Diffenderfer, M.R., Barrett, H.R., Welty, F.K., Cohn, J.S., Wilson, A., Wolfe, M.L., Martsupha, C., Schaefer, P.M., Digenio, A.G., Mancuso, J.P., Dolnikowski, G.G., Schaefer, E.J., Rader, D.J. 2008. Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism. Journal of Lipid Research. 49:543-549.
Effects of maximal doses of atorvastatin versus rosuvastatin on small dense low-density lipoprotein cholesterol levels - (Peer Reviewed Journal)
Masumi, A., Otokozawa, S.M., Asztalos, B.F., Nakajima, K., Jones, P., Schaefer, E. 2008. Effects of maximal doses of atorvastatin versus rosuvastatin on small dense low-density lipoprotein cholesterol levels. American Journal of Cardiology. 10:315-318.
Last Modified: 8/19/2014
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