Location: Mosquito and Fly Research Unit
2012 Annual Report
Research efforts by the Organic Chemistry group and the Mosquito and Fly Research Unit (MFRU) in Gainesville, FL, consisted of bioassays of novel compounds as mosquito repellents, larvicides, and adulticides. Compounds selected from a 1977 report on testing against Yellow Fever mosquitoes were selected and bioassayed for minimum effective dosage (to produce repellency) against Ae.aegypti mosquitoes. The efficacy data was used to generate an extremely accurate model of the structure and electronic properties of these models that lead to the observed repellent efficacy level. The quantitative structure activity relationship (3D-QSAR) methodology that is used by our University of Florida collaborators analyzes chemicals for repellent activity based on their structure and various other structurally-related chemical properties. In the past year, we completed testing of 20 compounds of which 1 showed comparable activity to N,N-diethyl-3-methylbenzamide (DEET) (the gold standard of repellents), 3 had relatively high repellent activity, and 5 had moderate repellent activity.