DISCOVERY OF NEW INSECTICIDES AND REPELLENTS BY STRUCTURE-PROPERTY BASED MODELS
Mosquito and Fly Research Unit
2010 Annual Report
1a.Objectives (from AD-416)
Predict chemical structures which will lead to the discovery of novel insecticides and repellents of mosquitoes and biting flies.
1b.Approach (from AD-416)
Compounds with known insecticidal and repellent properties will be selected for modeling from the USDA database of over 30,000 tested chemicals. The subsets of chemicals will be modeled by sophisticated modern computer systems to develop quantitative structure-activity/property relationships (qsar/qspr) to define and improve mosquito and fly insecticides and repellents. Candidate insecticides and repellents will be obtained commercially, or synthesized as needed. Chemicals will be bioassayed for insecticidal and/or repellent properties.
This project is related to Objective 1, “Discover and evaluate new toxicants and biological control agents for control of biting Nematocera” of the parent project.
Research efforts by the Organic Chemistry group and the Mosquito and Fly Research Unit (MFRU) consisted of bioassays of novel compounds as mosquito repellents, larvicides, and adulticides. Several promising compounds were founds as repellents (see Accomplishments in parent project). Recent success has been achieved with developing models for house fly insecticides and mosquito larvicides.
Progress is monitored through monthly reports via e-mail, meetings at MFRU held every 6 weeks, phone calls, and publication in scientific journals.