2010 Annual Report
Research on plant polysaccharide (PPS) derived matrices for colon-specific drug delivery, personal care and household applications continued. We prepared a series of hydrogel microparticles from pectin/zein and evaluated their physical, chemical, and biological activities in vivo (collaboration with scientists in Tajikistan). The preliminary results were summarized in a manuscript published by the Tajikistan Academy of Sciences demonstrating for the first time that pectin/zein-encapsulated drugs could be delivered to the colon following oral ingestion. The in vivo results also demonstrated the biocompatibility and non-toxicity of the pectin/protein microparticles.
Research on the synthesis of porous composite materials by extrusion-injection molding for engineering applications continued. Composites with porous structure were prepared from PLA and carbon nanotubes by melting-extrusion and injection-molding using a bench-top twin-crew extrusion. The mechanical properties of the composites were enhanced by the inclusion of the nanotubes; while thermal conductivity was able to be retained. This could be attributed to the porous structure of composites contributed by the nanotubes. Composite materials containing 95% sugar beet pulp and 5% poly(lactic acid) (PLA) were prepared by compression-heating method extruded in the presence of chemical cross-linkers. The mechanical properties of the resultant materials are similar to PLA.
Research on sugar beet and orange peel pectic oligosaccharides as potential function feed ingredients and prebiotic oligosaccharides continued. In vivo analysis of candidate prebiotics will be conducted once 20kg is produced in a commercial setting. Methods for enzymatic production of arabinose-rich pectic oligosaccharides are under investigation. See the subordinate project 1935-41000-068-04T annual report for further details. Hemicellulose oligosaccharides from citrus and cranberry with potential as prebiotics were further characterized by NMR.
Nunez, A., Fishman, M., Fortis, L.L., Cooke, P.H., Hotchkiss, A.T. 2009. Identification of extensin protein associated with sugar beet pectin. Journal of Agricultural and Food Chemistry. 57:10951-10958. Gibson, G.R., Scott, K.P., Rastall, R.A., Touhy, K.M., Hotchkiss, A., Dubert-Ferrandon, A., Gareau,M., Murphy,E.F., Saulnier, D., Loh, G., Macfarlane, S., Delzenne, N., Ringel, Y., Kozianowski, G., Dickman, R., Lenoir-Wijnkoop, I., Walker, C., Buddington,R. 2010. Dietary prebiotics: Current status and new definition. Journal of Food Science and Technology Bulletin: Functional Foods 7:1-19.
Liu, L.S., Jin, Z.T., Coffin, D.R., Liu, C., Hicks, K.B. 2010. Poly (lactic acid) membranes containing bacteriocins and EDTA for inhibition of the surface growth of gram-negative bacteria. Journal of Applied Polymer Science. 117(1):486-492. Liu, C., Liu, L.S., Latona, N.P., Ramos, M., Latona, R.J. 2010. The Use of Mixed Tocopherols to Improve UV and Heat Resistance of Leather. Journal of American Leather Chemists Association. 105(1):9-15.
Jiang, L., Liu, L.S., Chen, F., Qian, J., Jijun, H., Wolcott, M., Zhang, J. 2010. Reinforcing and Toughening Effects of Bamboo Pulp Fiber on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Fiber Composites. Industrial and Engineering Chemistry Research. 49:572-577.
Khalikova, M.D., Rakhimov, E.F., Babokalonov, D.T., Muhidinov, Z.K., Liu, L.S. 2010. Biocompatibility of Pectin-Protein Gels and Microencapsulates: In Vivo Study on Rats. Journal of Academy of Sciences of the Republic of Tajikistan. 52(5):386-390.
Sharifova, Z.B., Usmanova, C.P., Muhidinov, Z.K., Bobokalonov, J.T., Gorshkova, L.M., Liu, L.S. 2009. Characterization of microparticles prepared by emulsion method from pectin and protein. Journal of Academy of Sciences of the Republic of Tajikistan. 135(2):72-77.
Farris, S., Schaich, K.M., Liu, L.S., Piergiovanni, L., Yam, K.L. 2009. Development of polyion-complex hydrogels as an alternative approach for the production of bio-based polymers for food packaging applications: A review. Trends in Food Science and Technology, 20:316-332.
Hotchkiss, A.T., Rastall, R., Gibson, G., Eliaz, I., Liu, L.S., Fishman, M. 2009. New bioactive and biobased product applications of pectin. Book Chapter In: Schols, H.A., Visser, R.G.F., Voragen, A.G.J., editors. Pectins and Pectinases. Wageningen, The Netherlands: Wageningen Academic Publisher. p. 305-312.