2010 Annual Report 1a.Objectives (from AD-416) Determine the bioavailability of encapsulated pterostilbene using encapsulation technology developed by Food Science Australia. 1b.Approach (from AD-416) Pterostilbene will be synthesized then encapsulated. Encapsulated pterostilbene will be administered to mice/rats. Levels of pterostilbene in mouse/rat serum will be determined. 3.Progress Report This project is tied with Agreement Number: 6408-41000-006-12N. The objective of the project is to determine the bioavailability of encapsulated pterostilbene using encapsulation technology developed by Food Science and Technology, Australia. Administration of encapsulated pterostilbene to animals was to be performed by collaborator at Rutgers. However, due to budget constraints, collaborator was unable to perform feeding experiments. Feeding of encapsulated pterostilbene is underway with collaborators at University of Mississippi Department of Pharmacology. Methods used for monitoring or discussing research progress were by telephone call, email, and laboratory visits.