2011 Annual Report 1a.Objectives (from AD-416) Through this collaborative interaction the parties intend to coordinate research efforts so as to develop and implement obesity prevention programs and to identify gene-nutrient interactions that have been linked to chronic diseases, which can be used to improve and protect public health. 1b.Approach (from AD-416) This will be accomplished by developing obesity prevention research projects combining nutritional and lifestyle surveys, research interventions, with –omic technologies; collaborating in the use of research laboratories, research field sites, research volunteers, and designed research studies conducted or planned for implementation in the rural areas of Arkansas and other areas, as mutually agreed; identifying gene – nutrient interactions that are linked with chronic diseases including obesity by analyzing nutrient intakes, biological fluids, and genetic factors; and through developing computational methods for analyses of gene – nutrient interactions. 3.Progress Report During FY 11, the Delta Obesity Prevention Vitamin Study at the summer day camp site of the Boys, Girls, and Adults Community Development Center was closed for further enrollment of subjects/participants, but remains open for the analysis of data already collected. Data is being analyzed for nutrient intakes (and Healthy Eating Index Scores), physical activity and fitness, serum vitamin and metabolite levels (nine vitamins including thiamine, niacin, folate, pyridoxal, pyridoxine, riboflavin, and vitamins A, E, and D3; and two metabolites, S-adenosylmethionine and S-adenosylhomocysteine) and genomics. Comparisons will be made from year to year, within age groups, and individual food intake compared to physical activity measures (in small subsample) and individual genomics. Manuscripts are being developed by the collaborating groups at Delta Obesity Prevention Research Unit, the Personalized Medicine and Individualized Nutrition Group (FDA, National Center for Toxicological Research), and the staff of the Boys, Girls, and Adults Community Development Center. Monitoring of cooperator's performance and adherence to conditions of the agreement was by: site visits; quarterly reports consisting of budgetary material, progress towards goals and objectives, and review of publications and manuscripts in progress; and numerous conference calls and emails.