2009 Annual Report
1a.Objectives (from AD-416)
Through this collaborative interaction the parties intend to coordinate research efforts so as to develop and implement obesity prevention programs and to identify gene-nutrient interactions that have been linked to chronic diseases, which can be used to improve and protect public health.
1b.Approach (from AD-416)
This will be accomplished by developing obesity prevention research projects combining nutritional and lifestyle surveys, research interventions, with –omic technologies; collaborating in the use of research laboratories, research field sites, research volunteers, and designed research studies conducted or planned for implementation in the rural areas of Arkansas and other areas, as mutually agreed; identifying gene – nutrient interactions that are linked with chronic diseases including obesity by analyzing nutrient intakes, biological fluids, and genetic factors; and through developing computational methods for analyses of gene – nutrient interactions.
During FY 2009, we worked in cooperation with the USDA, Delta OPRU to write the protocol for "Delta Obesity Prevention Research Summer Day Camp". It was approved by NCTR administration, IRB and RIHSC committees. Recruitment began in June 2009. Blood samples were drawn, surveys assessing food intake completed, and preliminary data on caloric expenditure were obtained. The Summer Day Camp program children were also provided 2 nutritious meals and a healthy snack, throughout the day at camp. Data was collected that will be used in future exploratory research and publications.
Samples from participants in the 2008 feasibility study were analyzed for vitamin and metabolic levels. These data were presented to the FDA/NCTR Division of Personalized Nutrition and Medicine Science Advisory Board Review Committee in Bethesda, Maryland in August 2009. The data were presented in the form of slide presentations and posters.
Monitoring of collaborator's performance and adherence to conditions of the agreement was accomplished by 3 site visits, 2 research workshops, review of publications and manuscripts in progress, numerous committee meetings, conference calls and emails.
In cooperation with Center for Toxicoinformatics at NCTR, we directed the development of a tool that is used to map genes involved in nutrient metabolism to known quantitative trait loci. The QTL library tool will be added to the FDA ArrayTrack software suite and database. This web-site is managed by NCTR and is available for government and other researchers.