2010 Annual Report 1a.Objectives (from AD-416) ß-cryptoxanthin (CX) is a provitamin A carotenoid abundant in mandarin oranges. Supplementation with foods rich in CX may be an efficacious dietary intervention for improving breast milk vitamin A. Our objective is to assess the impact of daily supplementation with food sources of CX or beta-carotene (BC) on the plasma and breast milk concentrations of CX, BC and vitamin A in Bangladeshi women with marginal vitamin A status. 3.Progress Report Enrollment on this study continues. Approximately 75 volunteers have completed the study. A new rapid high-performance liquid chromatography method has been developed for the project, which can separate and measure b-cryptoxanthin, b-carotene, and their metabolites retinol, retinyl palmitate, and other carotenoids and retinoids. Laboratory work is in progress and is needed prior to analyzing data for effect of the intervention on nutritional status. ADODR monitoring is through a yearly site visit and frequent emails.