Publications (Clicking on the reprint icon will take you to the publication reprint.)

Berry fruit and nuts: their role in reducing oxidative stress and inflammation in the aging brain - (Book / Chapter)

Marshall, G., Shukitt Hale, B., Joseph, J.A. 2012. Berry fruit and nuts: their role in reducing oxidative stress and inflammation in the aging brain. In: Carkeet, C., editor. 2008 International Phytochemical Conference Book. CRC Press. p. 181-204.

Walnut diet reduces accumulation of polyubiquitinated proteins and inflammation in the brain of aged rats - (Peer Reviewed Journal)

Poulose, S., Bielinski, D., Shukitt Hale, B. 2012. Walnut diet reduces accumulation of polyubiquitinated proteins and inflammation in the brain of aged rats. Journal of Nutritional Biochemistry. DOI: 10.1016/j.jnutbio.2012.06.09.

The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells - (Peer Reviewed Journal)

Carey, A.N., Fisher, D.R., Joseph, J.J., Shukitt Hale, B. 2013. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. Nutritional Neuroscience. 16(1):13-20.

Berry fruit enhances beneficial signaling in brain - (Review Article)

Miller, M., Shukitt Hale, B. 2012. Berry fruit enhances beneficial signaling in brain. Journal of Agricultural and Food Chemistry. 60:5709-5715.

Anthocyanin-rich acai (Euterpe oleracea mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells - (Peer Reviewed Journal)

Poulose, S.M., Fisher, D.R., Larson, J., Bielinski, D.F., Rimando, A.M., Carey, A.N., Schauss, A.G., Shukitt Hale, B. 2012. Anthocyanin-rich acai (Euterpe oleracea mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells. Journal of Agricultural and Food Chemistry. 60:1084-1093.

Dietary supplementation with coffee improves motor and cognitive performance in aged rats - (Abstract Only)

Carey, A.N., Shukitt Hale, B. 2011. Dietary supplementation with coffee improves motor and cognitive performance in aged rats [abstract]. Gerontological Society of America. Program No. 955-17.

Effects of flavonoids on cognitive performance - (Book / Chapter)

Poulose, S.M., Shukitt Hale, B. 2012. Effects of flavonoids on cognitive performance. In: Spencer, J., Crozier, A., editors. Flavonoids and Related Compounds: Bioavailability and Function. United Kingdom: Taylor and Francis Group LLC, CRC Press. p. 393-411.

The behavioral and neuronal signaling benefits of polyphenols - (Abstract Only)

Shukitt Hale, B. 2011. The behavioral and neuronal signaling benefits of polyphenols. 5th International Conference on Polyphenols and Health [abstract}. Abstract No. 068.

Coffee and Alzheimer’s disease - animal & cellular evidences - (Book / Chapter)

Miller, M.G., Shukitt Hale, B. 2012. Coffee and Alzheimer’s disease - animal & cellular evidences. In: Chu, YiFang, editor. Coffee: Emerging Health Effects and Disease Prevention. New York, NY: John Wiley. p. 77-96.

Exposure to O-16 particle irradiation causes age-like decrements in rats through increased oxidative stress, inflammation and loss of autophagy - (Peer Reviewed Journal)

Poulose, S.M., Bielinski, D., Carrihill-Knoll, K., Rabin, B.M., Shukitt Hale, B. 2011. Exposure to O-16 particle irradiation causes age-like decrements in rats through increased oxidative stress, inflammation and loss of autophagy.Radiation Research. 176:761-769.

A blueberry enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress - (Peer Reviewed Journal)

Elks, C.M., Mariappan, N., Shukitt Hale, B., Joseph, J.A., Ingram, D.K., Francis, J. 2011. A blueberry enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress. PLoS One. 6(9)e24028.

Food for thought: what Jim Joseph taught me about aging and nutrition - (Abstract Only)

(03-May-11)

Operant responding following exposure to HZE particles and its relationship to particle energy and LET - (Peer Reviewed Journal)

Rabin, B.M., Carrihill-Knoll, K., Shukitt Hale, B. 2011. Operant responding following exposure to HZE particles and its relationship to particle energy and LET. Advances in Space Research. 48:370-377.

Interaction between age of irradiation and age of testing in the disruption of operant performance using a ground-based model for exposure to cosmic rays - (Peer Reviewed Journal)

Rabin, B.M., Joseph, J.A., Shukitt Hale, B., Carrihill-Knoll, K. 2012. Interaction between age of irradiation and age of testing in the disruption of operant performance using a ground-based model for exposure to cosmic rays. American Aging Association. 34:121-131.

Differential protection among fractionated blueberry polyphenolic families against DA-, ABeta 42 and LPS-induced decrements in Ca2+ buffering in primary hippocampal cells - (Peer Reviewed Journal)

Joseph, J.A., Shukitt Hale, B., Brewer, G.J., Weikel, K.A., Kalt, W., Fisher, D.R. 2010. Differential protection among fractionated blueberry polyphenolic families against DA-, ABeta 42 and LPS-induced decrements in Ca2+ buffering in primary hippocampal cells. Journal of Agriculture and Food Chemistry. 58:8196-8204.

Short-term blueberry-enriched antioxidant diet prevents and reverses object recognition memory loss in aged rats - (Peer Reviewed Journal)

Malin, D.H., Lee, D.R., Goyarzu, P., Chang, Y., Ennis, L.J., Beckett, E., Shukitt Hale, B., Joseph, J.A. 2011. Short-term blueberry-enriched antioxidant diet prevents and reverses object recognition memory loss in aged rats. Nutrition. 27:338-342.

Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: possible involvement of phospholipase D2 - (Peer Reviewed Journal)

Willis, L., Bielinski, D.F., Fisher, D.R., Matthan, N.R., Joseph, J.A. 2010. Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: possible involvement of phospholipase D2. Inflammation. 33(5):325.

Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cells involves alterations in stress signaling - (Peer Reviewed Journal)

Joseph, J.A., Bielinski, D., Fisher, D.R. 2010. Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cells involves alterations in stress signaling. Journal of Agricultural Food & Chemistry. 58:3380-3392.

Blueberry supplementation improves memory in older adults - (Peer Reviewed Journal)

Krikorian, R., Shidler, M., Nash, T., Kalt, W., Vinqvist-Tymchuk, M., Shukitt Hale, B., Joseph, J.A. 2010. Blueberry supplementation improves memory in older adults. Journal of Agricultural and Food Chemistry. 58:3996-4000.

Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats - (Peer Reviewed Journal)

Ismayil, A., Spangler, E., Shukitt Hale, B., Joseph, J.A., Ingram, D., Talan, M. 2009. Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats. PLoS One. 4(11):e7975.

Nutrition, brain aging, and neurodegeneration - (Review Article)

Joseph, J.A., Cole, G., Head, E., Ingram, D. 2009. Nutrition, brain aging, and neurodegeneration. Journal of Neuroscience. 29:12795-12801.

Concord Grape Juice Supplementation Improves Memory Function In Older Adults with Mild Cognitive Impairment - (Peer Reviewed Journal)

Krikorian, R., Nash, T.A., Shidler, M.D., Shukitt Hale, B., Joseph, J.A. 2009. Concord Grape Juice Supplementation Improves Memory Function In Older Adults with Mild Cognitive Impairment. British Journal of Nutrition. 103:730-734.

Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain - (Peer Reviewed Journal)

Willis, L., Shukitt Hale, B., Joseph, J.A. 2009. Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain. Genes and Nutrition. 4:309-314.

Blueberry-enriched diet protects rat heart from ischemic damage - (Peer Reviewed Journal)

Ahmet, I., Spangler, E., Shukitt Hale, B., Juhaszova, M., Sollott, S.J., Joseph, J.A., Ingram, D.K., Talan, M. 2009. Blueberry-enriched diet protects rat heart from ischemic damage. PLoS One. 4(5934):1-10.

Attenuation of iNOS and COX2 by blueberry polyphenols is mediated through the suppression of NF-KB activation - (Peer Reviewed Journal)

Lau, F., Joseph, J.A., Mcdonald, J.E., Kalt, W. 2009. Attenuation of iNOS and COX2 by blueberry polyphenols is mediated through the suppression of NF-KB activation. Journal of Functional Foods. 1(3):274-283.

Mitigation of oxidative stress and inflammatory signaling by fruit and walnut polyphenols: implications for cognitive aging - (Book / Chapter)

Joseph, J.J., Shukitt Hale, B., Willis, L. 2010. Mitigation of oxidative stress and inflammatory signaling by fruit and walnut polyphenols: implications for cognitive aging. In: Santos-Buelga, C., Escribano-Bailon, M., Lattanzio V., editors. Recent Advances in Polyphenol Research. Volume 2. Oxford, England: Blackwell Publishing Ltd. 2:283-293.