1a.Objectives (from AD-416):
The objectives of this cooperative research project are to:. 1)determine fecal egg count when goats and sheep graze bio-active forage plants or are offered bio-active plant materials;. 2)determine the impact of phytochemicals on Haemonchus contortus infections in goats and sheep; and. 3)determine anthelmintic potential of extracts from herbaceous and woody plants using a Caenorhabditis elegans in vitro assay and an adult Haemonchus/gerbil in vivo assay.
1b.Approach (from AD-416):
Laboratory experiments and pen and pasture studies with small ruminants will be conducted with forage plants, plant extracts, and isolated chemicals that have anthelmintic properties. Specifically, a laboratory assay using C. elegans will be established and used to identify plants with anthelmintic potential. An in vivo gerbil assay will be used to evaluate anthelmintic effects of plant materials on adult H. contortus worms. H. contortus control in meat goats and sheep will be measured by evaluating effects of plant materials on H. contortus egg production and worm burdens in pen-fed and grazing animals. Information obtained will enhance existing research-based management guidelines related to gastrointestinal parasite control in goats and sheep.
Fiscal Year 2012 Consolidated Appropriations Act (H.R. 2112) passed by Congress and signed by the President on November 18, 2011, authorized the closing of the office/laboratory at Beaver, West Virginia. The program at Beaver that was associated with this agreement was terminated retroactively to October 1, 2011. Currently awaiting Administrative Close-out for this project.