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United States Department of Agriculture

Agricultural Research Service

Research Project: MOLECULAR, CELLULAR, AND REGULATORY ASPECTS OF NUTRITIONAL METABOLISM DURING CHILDHOOD DEVELOPMENT

Location: Children's Nutrition Research Center

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

De novo synthesis of milk triglycerides in humans - (Peer Reviewed Journal)
Mohammad, M.A., Sunehag, A.L., Haymond, M.W. 2014. De novo synthesis of milk triglycerides in humans. American Journal of Physiology - Endocrinology and Metabolism. 306(7):E838-E847.
Body weight has no impact on self-esteem of minority children living in inner city, low-income neighborhoods: a cross-sectional study - (Peer Reviewed Journal)
Wong, W.W., Mikhail, C., Ortiz, C.L., Lathan, D., Moore, L.A., Konzelmann, K.L., Smith, E.O. 2014. Body weight has no impact on self-esteem of minority children living in inner city, low-income neighborhoods: a cross-sectional study. BMC Pediatrics. 14:19.
Dystropathology increases energy expenditure and protein turnover in the Mdx mouse model of Duchenne muscular dystrophy - (Peer Reviewed Journal)
Radley-Crabb, H.G., Marini, J.C., Sosa, H.A., Castillo, L.I., Grounds, M.D., Fiorotto, M.L. 2014. Dystropathology increases energy expenditure and protein turnover in the Mdx mouse model of Duchenne muscular dystrophy. PLoS One. 9(2):e89277.
Hemogenic endothelial cell specification requires c-kit, notch signaling, and p27-mediated cell-cycle control - (Peer Reviewed Journal)
Marcelo, K.L., Sills, T.M., Coskun, S., Vasavada, H., Sanglikar, S., Goldie, L.C., Hirschi, K.K. 2013. Hemogenic endothelial cell specification requires c-kit, notch signaling, and p27-mediated cell-cycle control. Developmental Cell. 27(5):504-515.
Characterization of "cis"-regulatory elements ("c"RE) associated with mammary gland function - (Abstract Only)
Rijnkels, M., Molenaar, A., Singh, K., Dobson, J., Oden, K., Jeyasankar, C., Freeman-Zadrowski, C., Lemay, D. 2013. Characterization of "cis"-regulatory elements ("c"RE) associated with mammary gland function [abstract]. Procedings of the 10th International Symposium on Milk Genomics and Human Health, October 1-3, 2013, Davis, California.
Race, socioeconomic status, and treatment center are associated with insulin pump therapy in youth in the first year following diagnosis of type 1 diabetes - (Peer Reviewed Journal)
Lin, M.H., Connor, C.G., Ruedy, K.J., Beck, R.W., Kollman, C., Buckingham, B., Redondo, M.J., Schatz, D., Haro, H., Lee, J.M., Tamborlane, W.V., Wood, J.R., Pediatric Diabetes Consortium. 2013. Race, socioeconomic status, and treatment center are associated with insulin pump therapy in youth in the first year following diagnosis of type 1 diabetes. Diabetes Technology & Theraputics. 15(11):929-934.
From genes to milk: Genomic organization and epigenetic regulation of the mammary transcriptome - (Peer Reviewed Journal)
Lemay, D.G., Pollard, K.S., Martin, W.F., Freeman-Zadrowski, C., Hernandez, J., Korf, I., German, J., Rijnkels, M. 2013. From genes to milk: Genomic organization and epigenetic regulation of the mammary transcriptome. PLoS One. 8(9):e75030.
Regulation of lipid synthesis genes and milk fat production in human mammary epithelial cells during secretory activation - (Peer Reviewed Journal)
Mohammad, M.A., Haymond, M.W. 2013. Regulation of lipid synthesis genes and milk fat production in human mammary epithelial cells during secretory activation. American Journal of Physiology - Endocrinology and Metabolism. 305(6):E700-E716.
Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood - (Review Article)
Abbott, D.H., Bacha, F. 2013. Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood. Fertility and Sterility. 100(2):2-11.
An update on the regulation of adipogenesis - (Review Article)
Chen, M., Tong, Q. 2013. An update on the regulation of adipogenesis. Drug Discovery Today: Disease Mechanisms. 10(1-2):e15-e19.
Severe hypoglycemia and diabetic ketoacidosis among youth with type 1 diabetes in the T1D Exchange clinic registry - (Peer Reviewed Journal)
Cengiz, E., Xing, D., Wong, J.C., Wolfsdorf, J.I., Haymond, M.W., Rewers, A., Shanmugham, S., Tamborlane, W.V., Willi, S.M., Seiple, D.L., Miller, K.M., Dubose, S.N., Beck, R.W. 2013. Severe hypoglycemia and diabetic ketoacidosis among youth with type 1 diabetes in the T1D Exchange clinic registry. Pediatric Diabetes. 14(6):447-454.
Early recognition of growth abnormalities permitting early intervention - (Review Article)
Haymond, M., Kappelgaard, A., Czernichow, P., Biller, B.M., Takano, K., Kiess, W. 2013. Early recognition of growth abnormalities permitting early intervention. Acta Paediatrica. 102(8):787-796.
Regulation of endothelial cell differentiation and specification - (Review Article)
Marcelo, K.L., Goldie, L.C., Hirschi, K.K. 2013. Regulation of endothelial cell differentiation and specification. Circulation Research. 112(9):1272-1287.
Retinopathy in youth with type 2 diabetes participating in the TODAY clinical trial - (Peer Reviewed Journal)
Today Study Group. 2013. Retinopathy in youth with type 2 diabetes participating in the TODAY clinical trial. Diabetes Care. 36(6):1772-1774.
The long-term impact of epigenetics and maternal influence on the neonate through milk-borne factors and nutrient status - (Proceedings)
Daniels, K., Farmer, C., Jimenez-Flores, R., Rijnkels, M. 2013. The long-term impact of epigenetics and maternal influence on the neonate through milk-borne factors and nutrient status. In: Proceedings of the American Society of Animal Science, Joint Annual Meeting of the American Dairy Science Association, Asociacion Mexicana de Produccion Animal, American Society of Animal Science, Canadian Society of Animal Science, and the Western Section American Society of Animal Science; Lactation Biology Symposium, July 15-19, 2012, Phoenix, Arizona. Journal of Animal Science. 91(2):673-675.
Types of pediatric diabetes mellitus defined by anti-islet autoimmunity and random C-peptide at diagnosis - (Peer Reviewed Journal)
Redondo, M.J., Rodriguez, L.M., Escalante, M., Smith, E.O., Balasubramanyam, A., Haymond, M.W. 2013. Types of pediatric diabetes mellitus defined by anti-islet autoimmunity and random C-peptide at diagnosis. Pediatric Diabetes. 14(5):333-340.
Unlocking the milk protein gene loci during mammary gland development and differentiation; a role for chromatin - (Abstract Only)
Rijnkels, M., Freeman-Zadrowski, C., Hernandez, J., Potluri, V., Wang, L., Li, W., Lemay, D. 2013. Unlocking the milk protein gene loci during mammary gland development and differentiation; a role for chromatin [abstract]. In: Proceedings of the Plant & Animal Genome XXI International Conference, Session: Genome Mapping, Tagging & Characterization: General Comparative, January 12-16, 2013, San Diego, California. P0681, p. 249.
25-hydroxyvitamin D in obese youth across the spectrum of glucose tolerance from normal to prediabetes to type 2 diabetes - (Peer Reviewed Journal)
De Las Heras, J., Rajakumar, K., Lee, S., Bacha, F., Holick, M.F., Arslanian, S.A. 2013. 25-hydroxyvitamin D in obese youth across the spectrum of glucose tolerance from normal to prediabetes to type 2 diabetes. Diabetes Care. 36(7):2048-2053.
Epigenetic modifications unlock the milk protein gene loci during mouse mammary gland development and differentiation - (Peer Reviewed Journal)
Rijnkels, M., Freeman-Zadrowski, C., Hernandez, J., Potluri, V., Wang, L., Li, W., Lemay, D.G. 2013. Epigenetic modifications unlock the milk protein gene loci during mouse mammary gland development and differentiation. PLoS One. 8(1)e53270:1-16.
Self-reported dietary intake of youth with recent onset of type 2 diabetes: Results from the TODAY study - (Peer Reviewed Journal)
Delahanty, L., Kriska, A., Edelstein, S., Amodei, N., Chadwick, J., Copeland, K., Galvin, B., El Ghormli, L., Haymond, M.W., Kelsey, M.M. 2013. Self-reported dietary intake of youth with recent onset of type 2 diabetes: Results from the TODAY study. Nutrition and Dietetics. 113(3):431-439.
Measuring beta-cell function relative to insulin sensitivity in youth: Does the hyperglycemic clamp suffice? - (Peer Reviewed Journal)
Sjaarda, L., Lee, S., Tfayli, H., Bacha, F., Bertolet, M., Arslanian, S. 2013. Measuring beta-cell function relative to insulin sensitivity in youth: Does the hyperglycemic clamp suffice? Diabetes Care. 36(6):1607-1612.
Indices of insulin secretion during a liquid mixed-meal test in obese youth with diabetes - (Peer Reviewed Journal)
Bacha, F., Gungor, N., Lee, S., De Las Heras, J., Arslanian, S. 2013. Indices of insulin secretion during a liquid mixed-meal test in obese youth with diabetes. Journal of Pediatrics. 162(5):924-929.
Sedentary behavior and physical activity in youth with recent onset of type 2 diabetes - (Peer Reviewed Journal)
Kriska, A., Delahanty, L., Edelstein, S., Amodei, N., Chadwick, J., Copeland, K., Galvin, B., El Ghormli, L., Haymond, M., Kelsey, M., Lassiter, C., Mayer-Davis, E., Milaszewski, K., Syme, A. 2013. Sedentary behavior and physical activity in youth with recent onset of type 2 diabetes. Pediatrics. 131(3):e850-e856.
Transcriptome profiling of microRNA by next-gen deep sequencing reveals known and novel miRNA species in the lipid fraction of human breast milk - (Peer Reviewed Journal)
Munch, E.M., Harris, R.A., Mohammad, M., Benham, A.L., Pejerrey, S.M., Showalter, L., Hu, M., Shope, C.D., Maningat, P.D., Gunaratne, P.H., Haymond, M., Aagaard, K. 2013. Transcriptome profiling of microRNA by next-gen deep sequencing reveals known and novel miRNA species in the lipid fraction of human breast milk. PLoS One. 8(2):e50564.
De novo synthesis is the main source of ornithine for citrulline production in neonatal pigs - (Peer Reviewed Journal)
Marini, J.C., Stoll, B., Didelija, I.C., Burrin, D.G. 2012. De novo synthesis is the main source of ornithine for citrulline production in neonatal pigs. American Journal of Physiology - Endocrinology and Metabolism. 303:(11)E1348-E1353.
G-Nest: a Gene Neighborhood Scoring Tool to Identify Co-Conserved, Co-Expressed Genes - (Peer Reviewed Journal)
Lemay, D.G., Martin, W.F., Hinrichs, A.S., Rijnkels, M., German, J., Korf, I., Pollard, K.S. 2012. G-NEST: A gene neighborhood scoring tool to identify co-conserved, co-expressed genes. BMC Bioinformatics. 13(253):1-17.
Role of leptin signaling in hemato-vascular development and niche function: Leptin receptor-mediated signaling regulates LT-HSC homeostasis in vivo - (Abstract Only)
Gonzales, N.M., Goldie, L.C. 2012. Role of leptin signaling in hemato-vascular development and niche function: Leptin receptor-mediated signaling regulates LT-HSC homeostasis in vivo [abstract]. The 2012 North American Vascular Biology Organization (NAVBO) Workshop, Session: Systems Biology of Vascular Disease and Metabolic Syndrome, October 14-18, 2013, Pacific Grove, California. Angiogenesis, 16(1):267-268.
Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis - (Peer Reviewed Journal)
Song, H., Yao, E., Lin, C., Gacayan, R., Chen, M., Chuang, P. 2012. Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proceedings of the National Academy of Sciences. 109(43):17531-17536.
Maternal obesity in the agouti viable yellow (Avy) mouse produces defective secretory activation that is associated with mammary inflammation and activation of adrenocorticosteroid-dependent gene expression - (Abstract Only)
Hadsell, D.L., Olea, W., Hadsell, L.A. 2012. Maternal obesity in the agouti viable yellow (Avy) mouse produces defective secretory activation that is associated with mammary inflammation and activation of adrenocorticosteroid-dependent gene expression [abstract]. Proceedings of the International Milk Genomics Consortium: 9th International Symposium Milk Genomics and Human Health conference, October 8-10, 2012, Wageningen, The Netherlands.
Metabolomic profiling of amino acids and beta-cell function relative to insulin sensitivity in youth - (Peer Reviewed Journal)
Michaliszyn, S.F., Sjaarda, L.A., Mihalik, S.J., Lee, S., Bacha, F., Chace, D.H., De Jesus, V.R., Vockley, J., Arslanian, S.A. 2012. Metabolomic profiling of amino acids and beta-cell function relative to insulin sensitivity in youth. Journal of Clinical Endocrinology and Metabolism. 97(11):E2119-E2124.
Progressive deterioration of beta-cell function in obese youth with type 2 diabetes - (Peer Reviewed Journal)
Bacha, F., Gungor, N., Lee, S., Arslanian, S.A. 2013. Progressive deterioration of beta-cell function in obese youth with type 2 diabetes. Pediatric Diabetes. 14(2):106-111.
In "silico" QTL mapping of maternal nurturing ability using the mouse divesity panel - (Peer Reviewed Journal)
Hadsell, D.L., Wei, J., Olea, W., Hadsell, L.A., Renwick, A., Thomson, P.C., Shariflou, M. 2012. In "silico" QTL mapping of maternal nurturing ability using the mouse divesity panel. Physiological Genomics. 44(16):787-798.
A single sample GnRHa stimulation test in the diagnosis of precocious puberty - (Review Article)
Yazndani, P., Lin, Y., Raman, V., Haymond, M.W. 2012. A single sample GnRHa stimulation test in the diagnosis of precocious puberty. International Journal of Pediatric Endocrinology. 23:1-6.
HbA(1c) diagnostic categories and beta-cell function relative to insulin sensitivity in overweight/obese adolescents - (Peer Reviewed Journal)
Sjaarda, L.A., Michaliszyn, S.F., Lee, S., Tfayli, H., Bacha, F., Farchoukh, L., Arslanian, S.A. 2012. HbA(1c) diagnostic categories and beta-cell function relative to insulin sensitivity in overweight/obese adolescents. Diabetes Care. 35(12):2559-2563.
Nursing frequency alters circadian patterns of mammary gene expression in lactating mice - (Abstract Only)
Hadsell, D.L., Olea, W., Rottman, L.W. 2012. Nursing frequency alters circadian patterns of mammary gene expression in lactating mice [abstract]. Proceedings of the ADSA-AMPA-ASAS-CSAS-WSASAS Joint Annual Conference, July 15-19, 2012, Phoenix, Arizona. 90(Suppl. 3):53. CDROM.
Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice - (Peer Reviewed Journal)
Ma, X., Lin, Y., Lin, L., Qin, G., Pereira, F.A., Haymond, M.W., Butte, N.F., Sun, Y. 2012. Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice. American Journal of Physiology - Endocrinology and Metabolism. 303(3):E422-E431.
Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes - (Peer Reviewed Journal)
Redondo, M.J., Rodriguez, L.M., Escalante, M., Smith, E.O., Haymond, M.W. 2012. Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes. Pediatric Diabetes. 13(7):564-571.
Gene regulation of UDP-galactose synthesis and transport: Potential rate limiting processes in initiation of milk production in humans - (Peer Reviewed Journal)
Mohammad, M.A., Hadsell, D.L., Haymond, M.W. 2012. Gene regulation of UDP-galactose synthesis and transport: Potential rate limiting processes in initiation of milk production in humans. American Journal of Physiology - Endocrinology and Metabolism. 303(3): E365-E376.
An obesity-dependent lactation defect in the viable yellow agouti mouse is associated with mammary inflammation - (Abstract Only)
Hadsell, D.L., Hadsell, L.A., Olea, W. 2012. An obesity-dependent lactation defect in the viable yellow agouti mouse is associated with mammary inflammation [abstract]. Proceedings of the 94th Annual Meeting and Expo of the Endocrine Society, Session: Obesity Topics, June 23–26, 2012, Houston, Texas. # MON-133.
Brown adipocyte differentiation is regulated by hedgehog signaling during development - (Abstract Only)
Chen, M., Nosavanh, L. 2012. Brown adipocyte differentiation is regulated by hedgehog signaling during development [abstract]. Proceedings of the 94th Annual Meeting and Expo of the Endocrine Society, Session: Adipose Tissue Development and Inflammation, June 23–26, 2012, Houston, Texas. # OR20-3.
Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial - (Peer Reviewed Journal)
Lee, S., Bacha, F., Hannon, T., Kuk, J.L., Boesch, C., Arslanian, S. 2012. Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. Diabetes. 61(11):2787-2795.
Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria - (Peer Reviewed Journal)
Nagamani, S., Campeau, P.M., Shchelochkov, O.A., Premkumar, M.H., Guse, K., Brunetti-Pierri, N., Chen, Y., Sun, Q., Tang, Y., Palmer, D., Reddy, A.K., Li, L., Slesnick, T.C., Feig, D.I., Caudle, S., Harrison, D., Salviati, L., Marini, J.C., Bryan, N.S., Erez, A., Lee, B. 2012. Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. The American Journal of Human Genetics. 90(5):836-846.
In utero glucocorticoid exposure reduced fetal skeletal muscle mass in rats independent of effects on maternal nutrition - (Peer Reviewed Journal)
Gokulakrishnan, G., Estrada, I.J., Sosahoracio, A., Fiorotto, M.L. 2012. In utero glucocorticoid exposure reduced fetal skeletal muscle mass in rats independent of effects on maternal nutrition. American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 302 (10):R1143-R1152.
Lactation biology symposium: Circadian clocks and photoperiod in mammary gland development and lactation - (Proceedings)
Hadsell, D.L. 2012. Lactation biology symposium: Circadian clocks and photoperiod in mammary gland development and lactation. Journal of Animal Science. 90(3):742-743.
Effect of ghrelin on glucose regulation in mice - (Peer Reviewed Journal)
Chacko, S.K., Haymond, M.W., Sun, Y., Marini, J.C., Sauer, P.J., Ma, X., Sunehag, A.L. 2012. Effect of ghrelin on glucose regulation in mice. American Journal of Physiology - Endocrinology and Metabolism. 302(9):E1055-E1062.
Arginine and ornithine are the main precursors for citrulline synthesis in mice - (Peer Reviewed Journal)
Marini, J.C. 2012. Arginine and ornithine are the main precursors for citrulline synthesis in mice. Journal of Nutrition. 142:572-580.
In-silico mapping of quantitative trait loci for lactation-associated traits in inbred mice - (Abstract Only)
Hadsell, D.L., Wei, J., Olea, W., Shariflou, M., Thomson, P.C., Renwick, A., Williamson, P. 2011. In-silico mapping of quantitative trait loci for lactation-associated traits in inbred mice [abstract]. Proceedings of the 8th International Symposium on Milk Genomics and Human Health, November 15-17, 2011, Melbourne, Australia.
Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs - (Peer Reviewed Journal)
Gazzaneo, M.C., Suryawan, A., Orellana, R.A., Torrazza, R.M., El-Kadi, S.W., Wilson, F.A., Kimbal, S.R., Srivastava, N., Nguyen, H.V., Fiorotto, M.L., Davis, T.A. 2011. Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs. Journal of Nutrition. 141(12):2152-2158.
Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study - (Peer Reviewed Journal)
Bacha, F., Pyle, L., Nadeau, K., Cuttler, L., Goland, R., Haymond, M., Levitsky, L., Lynch, J., Weinstock, R.S., White, N.H., Caprio, S., Arslanian, S. 2012. Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study. Pediatric Diabetes. 13(5):377-384.
Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine - (Review Article)
Chaudhury, H., Raborn, E., Goldie, L.C., Hirschi, K.K. 2011. Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine. Journal of Cells Tissues and Organs. 195(1-2):41-47.
Type 2 diabetes in youth: Are there racial differences in beta-cell responsiveness relative to insulin sensitivity? - (Peer Reviewed Journal)
Bacha, F., Gungor, N., Lee, S., Arslanian, S.A. 2012. Type 2 diabetes in youth: Are there racial differences in beta-cell responsiveness relative to insulin sensitivity? Pediatric Diabetes. 13(3):259-265.
Quantitative analysis of 15N labeled positional isomers of glutamine and citrulline via electrospray ionization tandem mass spectrometry of their dansyl derivatives - (Peer Reviewed Journal)
Marini, J.C. 2011. Quantitative analysis of 15N labeled positional isomers of glutamine and citrulline via electrospray ionization tandem mass spectrometry of their dansyl derivatives. Rapid Communications in Mass Spectrometry. 25(9):1291-1296.
The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow - (Peer Reviewed Journal)
Sivina, M., Yamada, T., Park, C.S., Puppi, M., Coskun, S., Hirschi, K., Lacorazza, H.D. 2011. The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow. Arteriosclerosis Thrombosis and Vascular Biology. 31(5):1185-1191.
Phenylbutyrate improves nitrogen disposal via alternative pathway without eliciting an increase in protein breakdown and catabolism in control and ornithine transcarbamylace-deficient patients - (Peer Reviewed Journal)
Marini, J.C., Lanpher, B.C., Scaglia, F., O'Brien, W.E., Sun, Q., Garlick, P.J., Jahoor, F., Lee, B. 2011. Phenylbutyrate improves nitrogen disposal via alternative pathway without eliciting an increase in protein breakdown and catabolism in control and ornithine transcarbamylace-deficient patients patients. American Journal of Clinical Nutrition. 93(6):1248-1254.
Short-term administration of rhGH increases markers of cellular proliferation, but not milk protein gene expression in normal lactating women. - (Peer Reviewed Journal)
Maningat, P.D., Sen, P., Rijnkels, M., Hadsell, D.L., Bray, M.S., Haymond, M.W. 2011. Short-term administration of rhGH increases markers of cellular proliferation, but not milk protein gene expression in normal lactating women. Physiological Genomics. 43:381-391.
Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle - (Peer Reviewed Journal)
Hadsell, D.L., Olea, W., Wei, J., Fiorotto, M.L., Matsunami, R.K., Engler, D.A., Collier, R.J. 2011. Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle. Physiological Genomics. 43(6):271-285.
Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging - (Peer Reviewed Journal)
Ma, X., Lin, L., Qin, G., Lu, X., Fiorotto, M.L., Dixit, V.D., Sun, Y. 2011. Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging. PLoS One. 6(1),e16391:1-10.
Arginase II reduces arginine availability and nitric oxide production during endotoxemia - (Abstract Only)
Marini, J.C., Didelija, I.C., Lee, B. 2011. Arginase II reduces arginine availability and nitric oxide production during endotoxemia [abstract]. Federation of American Societies for Experimental Biology Conference. 25:983.20.
Enteral arginase II provides ornithine for citrulline synthesis - (Peer Reviewed Journal)
Marini, J.C., Keller, B., Didelija, I.C., Castillo, L., Lee, B. 2011. Enteral arginase II provides ornithine for citrulline synthesis. American Journal of Physiology - Endocrinology and Metabolism. 300:E188-E194.
Arginine flux, but not nitric oxide synthesis, decreases in adolescent girls compared with adult women during pregnancy - (Peer Reviewed Journal)
Thame, M.M., Fletcher, H.M., Baker, T.M., Marini, J.C., Kao, C.C., Jahoor, F. 2010. Arginine flux, but not nitric oxide synthesis, decreases in adolescent girls compared with adult women during pregnancy. Journal of Nutrition. 141:71-74.
The Pediatric Diabetes Consortium: Improving care of children with Type 1 diabetes through collaborative research - (Review Article)
The Pediatric Diabetes Consortium 2010. The Pediatric Diabetes Consortium: Improving care of children with Type 1 diabetes through collaborative research. Diabetes Technology & Theraputics. 12(9):685-688.
Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity - (Peer Reviewed Journal)
Abbas, H.A., Maccio, D.R., Coskun, S., Jackson, J.G., Hazen, A.L., Sills, T.M., You, M.J., Hirschi, K.K., Lozano, G. 2010. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 7(5):606-617.
Insulin resistance in children: consensus, perspective, and future directions - (Peer Reviewed Journal)
Levy-Marchal, C., Arslanian, S., Cutfield, W., Sinaiko, A., Druet, C., et al. 2010. Insulin resistance in children: consensus, perspective, and future directions. Journal of Clinical Endocrinology and Metabolism. 95:5189-5198.
Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo - (Peer Reviewed Journal)
Enciso, J.M., Konecny, C.M., Karpen, H.E., Hirschi, K.K. 2010. Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo. Developmental Dynamics. 239(10):2570-2583.
Plasma arginine and ornithine are the main citrulline precursors in mice infused with arginine-free diets - (Peer Reviewed Journal)
Marini, J.C., Didelija, I.C., Castillo, L., Lee, B. 2010. Plasma arginine and ornithine are the main citrulline precursors in mice infused with arginine-free diets. Journal of Nutrition. 140(8):1432-1437.
Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals - (Peer Reviewed Journal)
Kazanis, I., Lathia, J.D., Vadakkan, T.J., Raborn, E., Wan, R., Mughal, M.R., Eckley, D.M., Sasaki, T., Patton, B., Mattson, M.P., Hirschi, K.K., Dickinson, M.E., Ffrench-Constant, C. 2010. Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. Journal of Neuroscience. 30(29):9771-9781.
Predictors of direct cost of diabetes care in pediatric patients with type 1 diabetes - (Peer Reviewed Journal)
Ying, A.K., Lairson, D.R., Giardino, A.P., Bondy, M.L., Zaheer, I., Haymond, M.W., Heptulla, R.A. 2011. Predictors of direct cost of diabetes care in pediatric patients with type 1 diabetes. Pediatric Diabetes. 12:177-182.
Glutamine: Precursor or nitrogen donor for citrulline synthesis? - (Peer Reviewed Journal)
Marini, J.C., Didelija, I.C., Castillo, L., Lee, B. 2010. Glutamine: Precursor or nitrogen donor for citrulline synthesis?. American Journal of Physiology - Endocrinology and Metabolism. 299(1):69-79.
Glutamine: precursor or nitrogen donor for citrulline synthesis? - (Abstract Only)
Marini, J.C., Didelija, I.C., Castillo, L., Lee, B. 2010. Glutamine: precursor or nitrogen donor for citrulline synthesis? [abstract]. Journal of Federation of American Societies for Experimental Biology. 24:740.14.
Characterization of bacterial artificial chromosome transgenic mice expressing mCherry fluorescent protein substituted for the murine smooth muscle-alpha-actin gene - (Peer Reviewed Journal)
Armstrong, J.J., Larina, I.V., Dickinson, M.E., Zimmer, W.E., Hirschi, K.K. 2010. Characterization of bacterial artificial chromosome transgenic mice expressing mCherry fluorescent protein substituted for the murine smooth muscle-alpha-actin gene. Genesis. 48:457-463.
Vascular precursors: origin, regulation and function - (Review Article)
Hirschi, K.K. 2010. Vascular precursors: origin, regulation and function. Arteriosclerosis Thrombosis and Vascular Biology. 30(6):1078-1079.
Vascular potential of human pluripotent stem cells - (Review Article)
Iacobas, I., Vats, A., Hirschi, K.K. 2010. Vascular potential of human pluripotent stem cells. Arteriosclerosis Thrombosis and Vascular Biology. 30(6):1110-1117.
Expression of angiogenic and vasculogenic proteins in the lung in alveolar capillary dysplasia/misalignment of pulmonary veins: an immunohistochemical study - (Peer Reviewed Journal)
Sen, P., Choudhury, T., Smith, E., Langston, C. 2010. Expression of angiogenic and vasculogenic proteins in the lung in alveolar capillary dysplasia/misalignment of pulmonary veins: an immunohistochemical study. Pediatric and Developmental Pathology. 13:354-361.
Age-dependent capacity to accelerate protein synthesis dictates the extent of compensatory growth in skeletal muscle following undernutrition     Reprint Icon - (Abstract Only)
Fiorotto, M.L., Davis, T.A., Sosa, H.A., Estrada, I.J., Watson, K.L., Karhson, D. 2010. Age-dependent capacity to accelerate protein synthesis dictates the extent of compensatory growth in skeletal muscle following undernutrition [abstract]. Federation of American Societies for Experimental Biology Conference, Session: Regulation of protein synthesis and breakdown by nutrients, exercise, and aging, April 24-28, 2010, Anaheim, California. Vol 24: Abstract No. 97.8.
Hemato-vascular origins of endothelial progenitor cell? - (Review Article)
Chao, H., Hirschi, K.K. 2010. Hemato-vascular origins of endothelial progenitor cell? Microvascular Research. 79(3):169-173.
Arginine utilization of citrulline synthesis in arginase II knockout mice - (Abstract Only)
Marini, J.C., Didelija, I.C., Castillo, L., Lee, B. 2010. Arginine utilization of citrulline synthesis in arginase II knockout mice [abstract]. Federation of American Societies for Experimental Biology 24:740.15.
Precursors for the synthesis of citrulline in mice fed arginine free diets - (Abstract Only)
Marini, J.C., Didelija, I.C., Castillo, L., Brendan, L. 2010. Precursors for the synthesis of citrulline in mice fed arginine free diets [abstract]. Journal of Federation of American Societies for Experimental Biology. 24:740.26.
The epigenetic landscape of mammary gland development and functional differentiation - (Peer Reviewed Journal)
Rijnkels, M., Kabotyanski, E., Montazer-Torbati, M.B., Beauvis, C.H., Vassetzky, Y., Rosen, J.M., Devinoy, E. 2010. The epigenetic landscape of mammary gland development and functional differentiation. Journal of Mammary Gland Biology and Neoplasia. 15:85-100.
Epigenetics in mammary gland biology and cancer - (Review Article)
Devinoy, E., Rijnkels, M. 2010. Epigenetics in mammary gland biology and cancer. Journal of Mammary Gland Biology and Neoplasia. 15:1-4.
Epigenetic modifications in 3D: Nuclear organization of the differentiating mammary epithelial cell - (Peer Reviewed Journal)
Kress, C., Ballester, M., Devinoy, E., Rijnkels, M. 2010. Epigenetic modifications in 3D: Nuclear organization of the differentiating mammary epithelial cell. Journal of Mammary Gland Biology and Neoplasia. 15:73-83.
Effects of maternal plasmid GHRH treatment on offspring growth     Reprint Icon - (Peer Reviewed Journal)
Khan, A.S., Bodles-Brakhop, A.M., Fiorotto, M.L. Draghia-Akli, R. 2010. Effects of maternal plasmid GHRH treatment on offspring growth. Vaccine. 28(8):1905-1910.
The effects of the in utero glucocorticoid (GLC) exposure on fetal skeletal muscle growth in rats - (Abstract Only)
Gokulakrishnan, G., Estrada, I., Fiorotto, M.L. 2010. The effects of the in utero glucocorticoid (GLC) exposure on fetal skeletal muscle growth in rats [abstract]. In: Proceedings of the 2010 Pediatric Academic Societies Annual Conference, May 1-4, 2010, Vancouver, British Columbia, Canada. Paper No. 3670.2.
In utero glucocorticoid (GLC) exposure and maternal undernutrition reduce fetal skeletal muscle mass by different mechanisms in rats - (Abstract Only)
Gokulakrishnan, G., Estrada, I.J., Sosa, H.A., Watson, K.L., Fiorotto, M.L. 2010. In utero glucocorticoid (GLC) exposure and maternal undernutrition reduce fetal skeletal muscle mass by different mechanisms in rats [abstract]. In: Proceedings of the 2010 Pediatric Academic Societies Annual Conference, May 1-4, 2010, Vancouver, British Columbia, Canada. Paper No. 1340.3.
Growth hormone: health considerations beyond height gain - (Peer Reviewed Journal)
Ross, J., Czernichow, P., Biller, B.M., Colao, A., Reiter, E., Kiess, W., and the participants in the advisory panel meeting on the effects of growth hormone. 2010. Growth hormone: health considerations beyond height gain. Pediatrics. 125:e906-e919.
Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin - (Peer Reviewed Journal)
Boles, M.K., Wilkinson, B.M., Wilming, L.G., Liu, B., Probst, F.J., Harrow, J., Grafham, D., Hentges, K.E., Woodward, L.P., Maxwell, A., Mitchell, K., Risley, M.D., Johnson, R., Hirschi, K., Lupski, J.R., Funato, Y., Miki, H., Marin-Garcia, P., Matthews, L., Coffey, A.J., Parker, A., Hubbard, T.J., Rogers, J., Bradley, A., Adams, D.J., Justice, M.J. 2009. Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genetics. 5(12):e1000759.
Epimorphic regeneration approach to tissue replacement in adult mammals - (Peer Reviewed Journal)
Agrawal, V., Johnson, S.A., Reing, J., Zhang, L., Tottey, S., Wang, G., Hirschi, K.K., Braunhut, S., Gudas, L.J., Badylak, S.F. 2010. Epimorphic regeneration approach to tissue replacement in adult mammals. Proceedings of the National Academy of Sciences. 107(8):3351-3355.
Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification - (Peer Reviewed Journal)
Fouletier-Dilling, C., Wada, A.M., Lazard, Z.W., Salisbury, E.A., Gannon, F.H., Vadakkan, T.J., Gao, L., Hirschi, K., Dickinson, M.E., Davis, A.R., Olmsted-Davis, E.A. 2010. Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification. Journal of Bone and Mineral Research. 25(5):1147-1156.
A comparison of the growth responses following intramuscular GHRH plasmid administration versus daily growth hormone injections in young pigs     Reprint Icon - (Peer Reviewed Journal)
Khan, A.S., Draghia-Akli-R., Shypailo, R.J., Ellis, K.I., Mersmann, H., Fiorotto, M.L. 2010. A comparison of the growth responses following intramuscular GHRH plasmid administration versus daily growth hormone injections in young pigs. Molecular Therapy. 18(2):327-333.
Design of a family-based lifestyle intervention for youth with type 2 diabetes: the TODAY study - (Review Article)
The TODAY Study Group, Haymond, M., Cuttler, L., Geffner, M., Katz, L. 2010. Design of a family-based lifestyle intervention for youth with type 2 diabetes: the TODAY study. International Journal of Obesity. 34:217-226.
Commentary: Need for Technological Innovation in Dietary Assessment - (Other)
Thompson, F.E., Subar, A.F., Loria, C.M., Reedy, J.L., Baranowski, T. 2010. Commentary: Need for Technological Innovation in Dietary Assessment. Journal of the American Dietetic Association. 110(1):48-51.
Effect of milking frequency (1 vs. 4x) on milk yield, composition and numbers of gene transcripts for alpha-lactalbumin and beta casein in milk - (Abstract Only)
Alex, A.P., Collier, J.L., Hadsell, D.L., Collier, R.J. 2009. Effect of milking frequency (1 vs. 4x) on milk yield, composition and numbers of gene transcripts for alpha-lactalbumin and beta casein in milk [abstract]. Journal of Animal Science. 87(E-Suppl.2):49.
The ability of exogenous growth hormone to maintain milk production during prolonged lactation in the mouse is more evident with reduced nursing frequency - (Abstract Only)
Hadsell, D.L., Olea, W., Parlow, A.F., Collier, R.J. 2009. The ability of exogenous growth hormone to maintain milk production during prolonged lactation in the mouse is more evident with reduced nursing frequency [abstract]. Journal of Animal Science. 87(E-Suppl.2):508.
Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements - (Peer Reviewed Journal)
Kabotyanski, E.B., Rijnkels, M., Freeman-Zadrowski, C., Buser, A.C., Edwards, D.P., Rosen, J.M. 2009. Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements. Journal of Biological Chemistry. 281:22815-22824.
The genome sequence of taurine cattle: A window to ruminant biology and evolution - (Peer Reviewed Journal)
The Bovine Genome Sequencing and Analysis Consortium, Elsik, C.G., Tellam, R.L., Worley, K.C. 2009. The genome sequence of taurine cattle: A window to ruminant biology and evolution. Science. 324(5926):522-528.
Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis - (Abstract Only)
Erez, A., Chen, Y., Shchelochkov, O.A., Nagamani, S.S., Mian, A., Bertin, T.K., Jiang, M., Black, J.0., Garg, H., Zeng, H., Summar, M., O'Brien, W.E., Mitch, W.E., Aschner, J.L., Marini, J.C., Bryan, N.S., Lee, B. 2009. Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis [abstract]. Molecular Genetics and Metabolism. 98:142.
Exposure to hyperoxia in the neonatal period alters bone marrow function - (Abstract Only)
Kienstra, K.A., Gonzales, N.M., Hirschi, K.K. 2009. Exposure to hyperoxia in the neonatal period alters bone marrow function [abstract]. Pediatric Academic Society. Abstract No. 5506.103.
Polymorphisms in the BCE and ECR3 regions on BTA6 and association analysis with production and management traits in dairy cattle - (Abstract Only)
Rincon, G., Rijnkels, M., Medrano, J.F. 2008. Polymorphisms in the BCE and ECR3 regions on BTA6 and association analysis with production and management traits in dairy cattle. In: Annual International Plant & Animal Genome Conference, January 10-14, 2009, San Diego, California. P475.
Reduced nursing frequency during prolonged lactation in the mouse decreases milk production and increases mammary expression of tryptophan hydroxylase 1 (TPH1), but does not accelerate mammary gland remodeling - (Abstract Only)
Hadsell, D.L., Olea, W., Torres, D., George, J., Collier, R.J. 2008. Reduced nursing frequency during prolonged lactation in the mouse decreases milk production and increases mammary expression of tryptophan hydroxylase 1 (TPH1), but does not accelerate mammary gland remodeling [abstract]. Journal of Animal Science. 86(E-Suppl.2):439.
Protein - (Book / Chapter)
Fiorotto, M.L. 2008. Protein, Chapter 14. Section III Micronutrients and Macronutrients. In: Kleinman, R.E., editor. Pediatric Nutrition Handbook. 6th edition. Elk Grove Village, IL: The American Academy of Pediatrics Publishers. p. 325-342.
Last Modified: 8/22/2014
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