Publications (Clicking on the reprint icon will take you to the publication reprint.)

Nursing frequency alters circadian patterns of mammary gene expression in lactating mice - (Abstract Only)

Hadsell, D.L., Olea, W., Rottman, L.W. 2012. Nursing frequency alters circadian patterns of mammary gene expression in lactating mice [abstract]. Proceedings of the ADSA-AMPA-ASAS-CSAS-WSASAS Joint Annual Conference, July 15-19, 2012, Phoenix, Arizona. 90(Suppl. 3):53. CDROM.

Gene regulation of UDP-galactose synthesis and transport: Potential rate limiting processes in initiation of milk production in humans - (Peer Reviewed Journal)

Mohammad, M.A., Hadsell, D.L., Haymond, M.W. 2012. Gene regulation of UDP-galactose synthesis and transport: Potential rate limiting processes in initiation of milk production in humans. American Journal of Physiology - Endocrinology and Metabolism. 303(3): E365-E376.

An obesity-dependent lactation defect in the viable yellow agouti mouse is associated with mammary inflammation - (Abstract Only)

Hadsell, D.L., Hadsell, L.A., Olea, W. 2012. An obesity-dependent lactation defect in the viable yellow agouti mouse is associated with mammary inflammation [abstract]. Proceedings of the 94th Annual Meeting and Expo of the Endocrine Society, Session: Obesity Topics, June 23–26, 2012, Houston, Texas. # MON-133.

Brown adipocyte differentiation is regulated by hedgehog signaling during development - (Abstract Only)

Chen, M., Nosavanh, L. 2012. Brown adipocyte differentiation is regulated by hedgehog signaling during development [abstract]. Proceedings of the 94th Annual Meeting and Expo of the Endocrine Society, Session: Adipose Tissue Development and Inflammation, June 23–26, 2012, Houston, Texas. # OR20-3.

Effect of ghrelin on glucose regulation in mice - (Peer Reviewed Journal)

Chacko, S.K., Haymond, M.W., Sun, Y., Marini, J.C., Sauer, P.J., Ma, X., Sunehag, A.L. 2012. Effect of ghrelin on glucose regulation in mice. American Journal of Physiology - Endocrinology and Metabolism. 302(9):E1055-E1062.

Arginine and ornithine are the main precursors for citrulline synthesis in mice - (Peer Reviewed Journal)

Marini, J.C. 2012. Arginine and ornithine are the main precursors for citrulline synthesis in mice. Journal of Nutrition. 142:572-580.

In-silico mapping of quantitative trait loci for lactation-associated traits in inbred mice - (Abstract Only)

Hadsell, D.L., Wei, J., Olea, W., Shariflou, M., Thomson, P.C., Renwick, A., Williamson, P. 2011. In-silico mapping of quantitative trait loci for lactation-associated traits in inbred mice [abstract]. Proceedings of the 8th International Symposium on Milk Genomics and Human Health, November 15-17, 2011, Melbourne, Australia.

Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs - (Peer Reviewed Journal)

Gazzaneo, M.C., Suryawan, A., Orellana, R.A., Torrazza, R.M., El-Kadi, S.W., Wilson, F.A., Kimbal, S.R., Srivastava, N., Nguyen, H.V., Fiorotto, M.L., Davis, T.A. 2011. Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs. Journal of Nutrition. 141(12):2152-2158.

Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study - (Peer Reviewed Journal)

Bacha, F., Pyle, L., Nadeau, K., Cuttler, L., Goland, R., Haymond, M., Levitsky, L., Lynch, J., Weinstock, R.S., White, N.H., Caprio, S., Arslanian, S. 2012. Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study. Pediatric Diabetes. 13(5):377-384.

Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine - (Review Article)

Chaudhury, H., Raborn, E., Goldie, L.C., Hirschi, K.K. 2011. Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine. Journal of Cells Tissues and Organs. 195(1-2):41-47.

Quantitative analysis of 15N labeled positional isomers of glutamine and citrulline via electrospray ionization tandem mass spectrometry of their dansyl derivatives - (Peer Reviewed Journal)

Marini, J.C. 2011. Quantitative analysis of 15N labeled positional isomers of glutamine and citrulline via electrospray ionization tandem mass spectrometry of their dansyl derivatives. Rapid Communications in Mass Spectrometry. 25(9):1291-1296.

The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow - (Peer Reviewed Journal)

Sivina, M., Yamada, T., Park, C.S., Puppi, M., Coskun, S., Hirschi, K., Lacorazza, H.D. 2011. The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow. Arteriosclerosis Thrombosis and Vascular Biology. 31(5):1185-1191.

Phenylbutyrate improves nitrogen disposal via alternative pathway without eliciting an increase in protein breakdown and catabolism in control and ornithine transcarbamylace-deficient patients - (Peer Reviewed Journal)

Marini, J.C., Lanpher, B.C., Scaglia, F., O'Brien, W.E., Sun, Q., Garlick, P.J., Jahoor, F., Lee, B. 2011. Phenylbutyrate improves nitrogen disposal via alternative pathway without eliciting an increase in protein breakdown and catabolism in control and ornithine transcarbamylace-deficient patients patients. American Journal of Clinical Nutrition. 93(6):1248-1254.

Short-term administration of rhGH increases markers of cellular proliferation, but not milk protein gene expression in normal lactating women. - (Peer Reviewed Journal)

Maningat, P.D., Sen, P., Rijnkels, M., Hadsell, D.L., Bray, M.S., Haymond, M.W. 2011. Short-term administration of rhGH increases markers of cellular proliferation, but not milk protein gene expression in normal lactating women. Physiological Genomics. 43:381-391.

Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle - (Peer Reviewed Journal)

Hadsell, D.L., Olea, W., Wei, J., Fiorotto, M.L., Matsunami, R.K., Engler, D.A., Collier, R.J. 2011. Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle. Physiological Genomics. 43(6):271-285.

Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging - (Peer Reviewed Journal)

Ma, X., Lin, L., Qin, G., Lu, X., Fiorotto, M.L., Dixit, V.D., Sun, Y. 2011. Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging. PLoS One. 6(1),e16391:1-10.

Arginase II reduces arginine availability and nitric oxide production during endotoxemia - (Abstract Only)

Marini, J.C., Didelija, I.C., Lee, B. 2011. Arginase II reduces arginine availability and nitric oxide production during endotoxemia [abstract]. Federation of American Societies for Experimental Biology Conference. 25:983.20.

Enteral arginase II provides ornithine for citrulline synthesis - (Peer Reviewed Journal)

Marini, J.C., Keller, B., Didelija, I.C., Castillo, L., Lee, B. 2011. Enteral arginase II provides ornithine for citrulline synthesis. American Journal of Physiology - Endocrinology and Metabolism. 300:E188-E194.

Arginine flux, but not nitric oxide synthesis, decreases in adolescent girls compared with adult women during pregnancy - (Peer Reviewed Journal)

Thame, M.M., Fletcher, H.M., Baker, T.M., Marini, J.C., Kao, C.C., Jahoor, F. 2010. Arginine flux, but not nitric oxide synthesis, decreases in adolescent girls compared with adult women during pregnancy. Journal of Nutrition. 141:71-74.

The Pediatric Diabetes Consortium: Improving care of children with Type 1 diabetes through collaborative research - (Review Article)

The Pediatric Diabetes Consortium 2010. The Pediatric Diabetes Consortium: Improving care of children with Type 1 diabetes through collaborative research. Diabetes Technology & Theraputics. 12(9):685-688.

Insulin resistance in children: consensus, perspective, and future directions - (Peer Reviewed Journal)

Levy-Marchal, C., Arslanian, S., Cutfield, W., Sinaiko, A., Druet, C., et al. 2010. Insulin resistance in children: consensus, perspective, and future directions. Journal of Clinical Endocrinology and Metabolism. 95:5189-5198.

Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo - (Peer Reviewed Journal)

Enciso, J.M., Konecny, C.M., Karpen, H.E., Hirschi, K.K. 2010. Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo. Developmental Dynamics. 239(10):2570-2583.

Plasma arginine and ornithine are the main citrulline precursors in mice infused with arginine-free diets - (Peer Reviewed Journal)

Marini, J.C., Didelija, I.C., Castillo, L., Lee, B. 2010. Plasma arginine and ornithine are the main citrulline precursors in mice infused with arginine-free diets. Journal of Nutrition. 140(8):1432-1437.

Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals - (Peer Reviewed Journal)

Kazanis, I., Lathia, J.D., Vadakkan, T.J., Raborn, E., Wan, R., Mughal, M.R., Eckley, D.M., Sasaki, T., Patton, B., Mattson, M.P., Hirschi, K.K., Dickinson, M.E., Ffrench-Constant, C. 2010. Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. Journal of Neuroscience. 30(29):9771-9781.

Predictors of direct cost of diabetes care in pediatric patients with type 1 diabetes - (Peer Reviewed Journal)

Ying, A.K., Lairson, D.R., Giardino, A.P., Bondy, M.L., Zaheer, I., Haymond, M.W., Heptulla, R.A. 2011. Predictors of direct cost of diabetes care in pediatric patients with type 1 diabetes. Pediatric Diabetes. 12:177-182.

Glutamine: Precursor or nitrogen donor for citrulline synthesis? - (Peer Reviewed Journal)

Marini, J.C., Didelija, I.C., Castillo, L., Lee, B. 2010. Glutamine: Precursor or nitrogen donor for citrulline synthesis?. American Journal of Physiology - Endocrinology and Metabolism. 299(1):69-79.

Glutamine: precursor or nitrogen donor for citrulline synthesis? - (Abstract Only)

Marini, J.C., Didelija, I.C., Castillo, L., Lee, B. 2010. Glutamine: precursor or nitrogen donor for citrulline synthesis? [abstract]. Journal of Federation of American Societies for Experimental Biology. 24:740.14.

Characterization of bacterial artificial chromosome transgenic mice expressing mCherry fluorescent protein substituted for the murine smooth muscle-alpha-actin gene - (Peer Reviewed Journal)

Armstrong, J.J., Larina, I.V., Dickinson, M.E., Zimmer, W.E., Hirschi, K.K. 2010. Characterization of bacterial artificial chromosome transgenic mice expressing mCherry fluorescent protein substituted for the murine smooth muscle-alpha-actin gene. Genesis. 48:457-463.

Vascular precursors: origin, regulation and function - (Review Article)

Hirschi, K.K. 2010. Vascular precursors: origin, regulation and function. Arteriosclerosis Thrombosis and Vascular Biology. 30(6):1078-1079.

Vascular potential of human pluripotent stem cells - (Review Article)

Iacobas, I., Vats, A., Hirschi, K.K. 2010. Vascular potential of human pluripotent stem cells. Arteriosclerosis Thrombosis and Vascular Biology. 30(6):1110-1117.

Expression of angiogenic and vasculogenic proteins in the lung in alveolar capillary dysplasia/misalignment of pulmonary veins: an immunohistochemical study - (Peer Reviewed Journal)

Sen, P., Choudhury, T., Smith, E., Langston, C. 2010. Expression of angiogenic and vasculogenic proteins in the lung in alveolar capillary dysplasia/misalignment of pulmonary veins: an immunohistochemical study. Pediatric and Developmental Pathology. 13:354-361.

Age-dependent capacity to accelerate protein synthesis dictates the extent of compensatory growth in skeletal muscle following undernutrition     - (Abstract Only)

Fiorotto, M.L., Davis, T.A., Sosa, H.A., Estrada, I.J., Watson, K.L., Karhson, D. 2010. Age-dependent capacity to accelerate protein synthesis dictates the extent of compensatory growth in skeletal muscle following undernutrition [abstract]. Federation of American Societies for Experimental Biology Conference, Session: Regulation of protein synthesis and breakdown by nutrients, exercise, and aging, April 24-28, 2010, Anaheim, California. Vol 24: Abstract No. 97.8.

Hemato-vascular origins of endothelial progenitor cell? - (Review Article)

Chao, H., Hirschi, K.K. 2010. Hemato-vascular origins of endothelial progenitor cell? Microvascular Research. 79(3):169-173.

Arginine utilization of citrulline synthesis in arginase II knockout mice - (Abstract Only)

Marini, J.C., Didelija, I.C., Castillo, L., Lee, B. 2010. Arginine utilization of citrulline synthesis in arginase II knockout mice [abstract]. Federation of American Societies for Experimental Biology 24:740.15.

Precursors for the synthesis of citrulline in mice fed arginine free diets - (Abstract Only)

Marini, J.C., Didelija, I.C., Castillo, L., Brendan, L. 2010. Precursors for the synthesis of citrulline in mice fed arginine free diets [abstract]. Journal of Federation of American Societies for Experimental Biology. 24:740.26.

The epigenetic landscape of mammary gland development and functional differentiation - (Peer Reviewed Journal)

Rijnkels, M., Kabotyanski, E., Montazer-Torbati, M.B., Beauvis, C.H., Vassetzky, Y., Rosen, J.M., Devinoy, E. 2010. The epigenetic landscape of mammary gland development and functional differentiation. Journal of Mammary Gland Biology and Neoplasia. 15:85-100.

Epigenetics in mammary gland biology and cancer - (Review Article)

Devinoy, E., Rijnkels, M. 2010. Epigenetics in mammary gland biology and cancer. Journal of Mammary Gland Biology and Neoplasia. 15:1-4.

Epigenetic modifications in 3D: Nuclear organization of the differentiating mammary epithelial cell - (Peer Reviewed Journal)

Kress, C., Ballester, M., Devinoy, E., Rijnkels, M. 2010. Epigenetic modifications in 3D: Nuclear organization of the differentiating mammary epithelial cell. Journal of Mammary Gland Biology and Neoplasia. 15:73-83.

Effects of maternal plasmid GHRH treatment on offspring growth     - (Peer Reviewed Journal)

Khan, A.S., Bodles-Brakhop, A.M., Fiorotto, M.L. Draghia-Akli, R. 2010. Effects of maternal plasmid GHRH treatment on offspring growth. Vaccine. 28(8):1905-1910.

The effects of the in utero glucocorticoid (GLC) exposure on fetal skeletal muscle growth in rats - (Abstract Only)

Gokulakrishnan, G., Estrada, I., Fiorotto, M.L. 2010. The effects of the in utero glucocorticoid (GLC) exposure on fetal skeletal muscle growth in rats [abstract]. In: Proceedings of the 2010 Pediatric Academic Societies Annual Conference, May 1-4, 2010, Vancouver, British Columbia, Canada. Paper No. 3670.2.

In utero glucocorticoid (GLC) exposure and maternal undernutrition reduce fetal skeletal muscle mass by different mechanisms in rats - (Abstract Only)

Gokulakrishnan, G., Estrada, I.J., Sosa, H.A., Watson, K.L., Fiorotto, M.L. 2010. In utero glucocorticoid (GLC) exposure and maternal undernutrition reduce fetal skeletal muscle mass by different mechanisms in rats [abstract]. In: Proceedings of the 2010 Pediatric Academic Societies Annual Conference, May 1-4, 2010, Vancouver, British Columbia, Canada. Paper No. 1340.3.

Growth hormone: health considerations beyond height gain - (Peer Reviewed Journal)

Ross, J., Czernichow, P., Biller, B.M., Colao, A., Reiter, E., Kiess, W., and the participants in the advisory panel meeting on the effects of growth hormone. 2010. Growth hormone: health considerations beyond height gain. Pediatrics. 125:e906-e919.

Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin - (Peer Reviewed Journal)

Boles, M.K., Wilkinson, B.M., Wilming, L.G., Liu, B., Probst, F.J., Harrow, J., Grafham, D., Hentges, K.E., Woodward, L.P., Maxwell, A., Mitchell, K., Risley, M.D., Johnson, R., Hirschi, K., Lupski, J.R., Funato, Y., Miki, H., Marin-Garcia, P., Matthews, L., Coffey, A.J., Parker, A., Hubbard, T.J., Rogers, J., Bradley, A., Adams, D.J., Justice, M.J. 2009. Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genetics. 5(12):e1000759.

Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification - (Peer Reviewed Journal)

Fouletier-Dilling, C., Wada, A.M., Lazard, Z.W., Salisbury, E.A., Gannon, F.H., Vadakkan, T.J., Gao, L., Hirschi, K., Dickinson, M.E., Davis, A.R., Olmsted-Davis, E.A. 2010. Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification. Journal of Bone and Mineral Research. 25(5):1147-1156.

A comparison of the growth responses following intramuscular GHRH plasmid administration versus daily growth hormone injections in young pigs     - (Peer Reviewed Journal)

Khan, A.S., Draghia-Akli-R., Shypailo, R.J., Ellis, K.I., Mersmann, H., Fiorotto, M.L. 2010. A comparison of the growth responses following intramuscular GHRH plasmid administration versus daily growth hormone injections in young pigs. Molecular Therapy. 18(2):327-333.

Design of a family-based lifestyle intervention for youth with type 2 diabetes: the TODAY study - (Review Article)

The TODAY Study Group, Haymond, M., Cuttler, L., Geffner, M., Katz, L. 2010. Design of a family-based lifestyle intervention for youth with type 2 diabetes: the TODAY study. International Journal of Obesity. 34:217-226.

Commentary: Need for Technological Innovation in Dietary Assessment - (Other)

Thompson, F.E., Subar, A.F., Loria, C.M., Reedy, J.L., Baranowski, T. 2010. Commentary: Need for Technological Innovation in Dietary Assessment. Journal of the American Dietetic Association. 110(1):48-51.

Effect of milking frequency (1 vs. 4x) on milk yield, composition and numbers of gene transcripts for alpha-lactalbumin and beta casein in milk - (Abstract Only)

Alex, A.P., Collier, J.L., Hadsell, D.L., Collier, R.J. 2009. Effect of milking frequency (1 vs. 4x) on milk yield, composition and numbers of gene transcripts for alpha-lactalbumin and beta casein in milk [abstract]. Journal of Animal Science. 87(E-Suppl.2):49.

The ability of exogenous growth hormone to maintain milk production during prolonged lactation in the mouse is more evident with reduced nursing frequency - (Abstract Only)

Hadsell, D.L., Olea, W., Parlow, A.F., Collier, R.J. 2009. The ability of exogenous growth hormone to maintain milk production during prolonged lactation in the mouse is more evident with reduced nursing frequency [abstract]. Journal of Animal Science. 87(E-Suppl.2):508.

Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements - (Peer Reviewed Journal)

Kabotyanski, E.B., Rijnkels, M., Freeman-Zadrowski, C., Buser, A.C., Edwards, D.P., Rosen, J.M. 2009. Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements. Journal of Biological Chemistry. 281:22815-22824.

Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis - (Abstract Only)

Erez, A., Chen, Y., Shchelochkov, O.A., Nagamani, S.S., Mian, A., Bertin, T.K., Jiang, M., Black, J.0., Garg, H., Zeng, H., Summar, M., O'Brien, W.E., Mitch, W.E., Aschner, J.L., Marini, J.C., Bryan, N.S., Lee, B. 2009. Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis [abstract]. Molecular Genetics and Metabolism. 98:142.

Exposure to hyperoxia in the neonatal period alters bone marrow function - (Abstract Only)

Kienstra, K.A., Gonzales, N.M., Hirschi, K.K. 2009. Exposure to hyperoxia in the neonatal period alters bone marrow function [abstract]. Pediatric Academic Society. Abstract No. 5506.103.

Polymorphisms in the BCE and ECR3 regions on BTA6 and association analysis with production and management traits in dairy cattle - (Abstract Only)

Rincon, G., Rijnkels, M., Medrano, J.F. 2008. Polymorphisms in the BCE and ECR3 regions on BTA6 and association analysis with production and management traits in dairy cattle. In: Annual International Plant & Animal Genome Conference, January 10-14, 2009, San Diego, California. P475.

Reduced nursing frequency during prolonged lactation in the mouse decreases milk production and increases mammary expression of tryptophan hydroxylase 1 (TPH1), but does not accelerate mammary gland remodeling - (Abstract Only)

Hadsell, D.L., Olea, W., Torres, D., George, J., Collier, R.J. 2008. Reduced nursing frequency during prolonged lactation in the mouse decreases milk production and increases mammary expression of tryptophan hydroxylase 1 (TPH1), but does not accelerate mammary gland remodeling [abstract]. Journal of Animal Science. 86(E-Suppl.2):439.

Protein - (Book / Chapter)

Fiorotto, M.L. 2008. Protein, Chapter 14. Section III Micronutrients and Macronutrients. In: Kleinman, R.E., editor. Pediatric Nutrition Handbook. 6th edition. Elk Grove Village, IL: The American Academy of Pediatrics Publishers. p. 325-342.