Publications (Clicking on the reprint icon will take you to the publication reprint.)

Defining the Optimal Selenium Dose for Prostate Cancer Risk Reduction: Insights from the U-Shaped Relationship Between Selenium Status, DNA Damage, and Apoptosis     - (Peer Reviewed Journal)

Chiang, E.C., Shen, S., Kengeri, S.S., Xu, H., Combs, G.F., Morris, J.S., Bostwick, D.G., Waters, D.J. 2010. Defining the Optimal Selenium Dose for Prostate Cancer Risk Reduction: Insights from the U-Shaped Relationship Between Selenium Status, DNA Damage, and Apoptosis. Dose Response. 8:285-300.

Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells - (Peer Reviewed Journal)

Zeng, H., Trujillo, O.N., Moyer, M.P., Botnen, J.H. 2011. Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells. Nutrition and Cancer. 63(2):248-255.

The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa - (Peer Reviewed Journal)

Uthus, E.O., Begaye, A., Ross, S., Zeng, H. 2010. The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa. Biological Trace Element Research. DOI 10.1007/s2011-010-8764-4.

Impaired Homocysteine Transmethylation and Protein-Methyltransferase Activity Reduce Expression of Selenoprotein P: Implications for Obesity and Metabolic Syndrome     - (Abstract Only)

Jackson, M.I., Combs, G.F. 2010. Impaired Homocysteine Transmethylation and Protein-Methyltransferase Activity Reduce Expression of Selenoprotein P: Implications for Obesity and Metabolic Syndrome. Journal of Federation of American Societies for Experimental Biology. 24:lb280

Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis - (Abstract Only)

Yan, L., Spitznagel, E.L., Bosland, M.C. 2010. Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis. Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington DC. Philadelphia (PA): AACR; 2010; 2010. Abst nr. 1893.

Effect of Chitosan on the Induction of DNA Damage Response by Selenium Compounds     - (Abstract Only)

Zhang, S., Zeng, H., Luo, Y., Wang, Q., Cheng, W. 2010. Effect of Chitosan on the Induction of DNA Damage Response by Selenium Compounds. Journal of Federation of American Societies for Experimental Biology. 24:lb251.

Methylselenol, a Selenium Metabolite, Plays Common and Different Roles in Colonic Cancer and Nontumorigenic Colonic Cell Growth     - (Abstract Only)

Zeng, H., Briske Anderson, M.J., Moyer, M.P. 2010. Methylselenol, a Selenium Metabolite, Plays Common and Different Roles in Colonic Cancer and Nontumorigenic Colonic Cell Growth. Journal of Federation of American Societies for Experimental Biology. 24:916.5.

Prolonged Sulforaphane Treatment Activates Extracellular-Regulated Kinase 1/2 Signaling in Nontumorigenic Colon Cells but not Colon Cancer Cells     - (Abstract Only)

Zeng, H., Trujillo, O., Moyer, M.P., Botnen, J.H. 2010. Prolonged Sulforaphane Treatment Activates Extracellular-Regulated Kinase 1/2 Signaling in Nontumorigenic Colon Cells but not Colon Cancer Cells. Journal of Federation of American Societies for Experimental Biology. 24:928.4.

Nutritional Impacts of Saskatchewan Grown Lentils (Lens culinaris L) Feeding on Samples of Healthy and Clinical Children in Sri Lanka - (Abstract Only)

Thavarajah, D., Thavarajah, P., Wijesuriya, P., Jayatiss, R., Combs, G.F., Lolande, D., See, C.T., Goetz, B., Rutzky, M., Arndt, A., Prange, A., Homes, J., Vandenberg, A. 2010. Nutritional Impacts of Saskatchewan Grown Lentils (Lens culinaris L) Feeding on Samples of Healthy and Clinical Children in Sri Lanka [abstract]. Saskatchewan Pulse Growers Pulse Days 2010. p. 44.

Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis - (Peer Reviewed Journal)

Yan, L., Spitznaagel, E.L., Bosland, M.C. 2010. Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis. Cancer Epidemiology Biomarkers and Prevention. 19(1):148-158.

Selenium Bioavailability from Soy Protein Isolate and Tofu in Rats Fed a Torula Yeast-Based Diet - (Peer Reviewed Journal)

Yan, L., Graef, G.L., Reeves, P.G., Johnson, L.K. 2009. Selenium Bioavailability from Soy Protein Isolate and Tofu in Rats Fed a Torula Yeast-Based Diet. Journal of Agriculture and Food Chemistry. 57:11575-11580.

Methylselenol, a Selenium Metabolite, Induces Cell Cycle Arrest in G1 Phase and Apoptosis via the Extracellular-Regulated Kinase 1/2 Pathway and Other Cancer Signaling Genes     - (Peer Reviewed Journal)

Zeng, H., Wu, M., Botnen, J.H. 2009. Methylselenol, a Selenium Metabolite, Induces Cell Cycle Arrest in G1 Phase and Apoptosis via the Extracellular-Regulated Kinase 1/2 Pathway and Other Cancer Signaling Genes. Journal of Nutrition. 139:1613-1618.