2012 Annual Report
1A. Determine if higher whole-grain intake is associated with less visceral adiposity and a lower waist circumference. 1B. Determine if diet differs between “metabolically healthy but obese" (MHO) individuals and “metabolically abnormal obese” (MAO) individuals. 1C. Determine if higher intakes of various classes of flavonoids are associated with a healthier profile of intermediate markers of CVD risk. 1D. Determine if a plant-based diet will improve the diet quality and consequently affect disease risk through its effects on underlying inflammation, lipid metabolism, insulin sensitivity and endothelial function. 1E. Determine if higher whole grain intake is associated with a lower risk congestive heart failure (CHF)
2. Determine the validity of biomarkers for whole grain intake, their use in assessing relationships between whole grain intake and disease risk, and the relationship between these biomarkers and insulin resistance phenotypes. 3. Using an epidemiologic approach, examine determinants of adherence to the recommended dietary patterns in the Dietary Guidelines for Americans (DGA) and the relation between adherence to these patterns and prevention of age-related weight gain, abdominal obesity, and related metabolic disorders such as inflammation, endothelial dysfunction and insulin resistance. 4. Using an epidemiologic approach, investigate safe upper limits for the dietary intake of folic acid. 5. Using an epidemiologic approach, determine relationships between dietary intake and nutrient status and the prevention of age-related cognitive decline in humans. 6. Using an epidemiologic approach, investigate the role of nutritional factors in limiting the coromorbidities such as CVD and premature mortality in individuals with chronic kidney disease (CKD).
LAB: Dietary Assessment 1. Use an epidemiologic approach to determine if micronutrient intake and dietary patterns are associated with bone status and fracture risk in older adults.
2. Use an epidemiologic approach to determine if micronutrient intake and dietary patterns are associated with depression and cognitive function in older adults.
3. Use an epidemiologic approach to identify behavioral factors that are associated with obesity in diverse population groups.
4. Use an epidemiologic approach to determine how genetic polymorphisms modify dietary effects on risk of diabetes in older adults.
5. Use an epidemiologic approach to determine associations between stress, diabetes and physical disability in older Puerto Rican adults, and the role of dietary patterns in moderating these associations.
LAB: Dietary Assessment We will achieve project objectives by continuing to work with existing cohorts of aging adults in the US population, including our own Boston Puerto Rican Health Study and Nutrition and Memory in the Elderly Study, and through active collaboration with the Framingham Studies, the Baltimore Longitudinal Study on Aging and the VA Normative Aging Study. In each of these, we either collect and analyze or interpret dietary intake and/or biochemical measures and relate them to health outcomes. In addition, we will collaborate across the ARS Human Nutrition Research Centers to conduct a new multi-center assessment of barriers and facilitators of adherence to dietary guidelines to prevent obesity. Together this body of work will contribute to a better understanding of the importance of specific foods, nutrients and dietary patterns in health maintenance with aging and in prevention of obesity and related chronic conditions.
Hazra, A., Krafts, P., Lazarus, R., Chen, C., Chanock, S.J., Jacques, P.F., Selhub, J., Hunter, D.J. 2009. Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Human Molecular Genetics. 18(23):4677-4687.
Mckeown, N.M., Meigs, J.B., Liu, S., Rogers, G., Yoshida, M., Saltzman, E., Jacques, P.F. 2009. Dietary carbohydrates and cardiovascular disease risk factors in the Framingham Offspring Cohort. Journal of American College of Nutrition. 28(2):150-158.
Imamura, F., Lichtenstein, A.H., Dallal, G.E., Meigs, J.B., Jacques, P.F. 2009. Confounding by dietary patterns of the inverse association between alcohol consumption and type 2 diabetes risk. American Journal of Epidemiology. 170(1):37-45.
Morris, M.S., Selhub, J., Jacques, P.F. 2012. Vitamin B-12 and folate status in relation to decline in scores on the Mini-Mental State Examination in the Framingham Heart Study. Journal of the American Geriatrics Society. 60(8):1457-1464.