1a.Objectives (from AD-416):
Through a joint USARIEM/MRMC and BHNRC/USDA biomedical research initiative, develop practical biomedical models of human energy metabolism.
1b.Approach (from AD-416):
USDA’s BHNRC will host an applied mathematician supported as a MRMC TATRC-funded IPA from the University of Tennessee. As a visiting scientist at BHNRC/USDA to jointly develop advanced mathematical models to predict the water and metabolic fuel requirements of physically active humans.
This nonfunded project is the same as a subsequently funded project (reimbursable agreement #60-1235-0-0168). Through this collaboration, we are developing advanced mathematical models to predict the water and metabolic fuel requirements of physically active humans. A study was conducted to determine glucose regulation and substrate oxidation patterns in 10 people, aged 65 - 75 who were untrained with a slightly impaired glucose tolerance. Walking after each meal was significantly more effective than 45 min of sustained walking in the morning or afternoon in lowering post-dinner glucose. These data were used to develop mathematical models of substrate oxidation patterns and to investigate the lag time associated with switching from one metabolic fuel to another.