1a.Objectives (from AD-416)
Objective 1. Document the pathogenesis of BVDV in offspring of deer infected during pregnancy.
Objective 2. Study the transmission of BVDV from persistently infected cervids to cattle.
1b.Approach (from AD-416)
The overall goal of this application is the determination of the role of white-tailed deer as reservoirs of BVDV for domestic cattle. Our research objectives are:
1) Document the fetal pathogenesis resulting from BVDV infection of pregnant does.
2) Determine the ability of BVDV persistently infected deer to transmit BVDV to cattle or deer.
To meet our research objectives we will infect pregnant white-tailed deer with BVDV in order to generate persistently infected (PI) fawns. To study transmission between cattle and deer we will expose BVDV naive cattle to fawns directly, to contaminated housing, or to contaminated feed.
Bovine viral diarrhea viruses (BVDV) cause either short-term (acute) or life-long (persistent) infections in cattle. Persistently infected cattle are one of the major means by which BVDV is spread from herd to herd. In previous experiments we demonstrated that BVDV may cause acute and persistent infections in white-tailed deer. In this reporting period, we completed experiments that demonstrate the transmission of BVDV from acutely infected deer to cattle via shared feeding equipment and housing. This opens the possibility that wild deer could transfer BVDV from one domestic cattle herd to another by using feed bunks and salt licks, and sharing pasture. Progress has been monitored by bi-yearly onsite visits by a cooperating South Dakota State University scientist.