Location: Human Nutrition Research Center on Aging
2011 Annual Report
2. Conduct clinical studies to determine the effects of dietary protein and dietary acid-base balance on bone and muscle metabolism and function, respectively, in older adults.
3. Determine the role and mechanisms of action for calcium, magnesium, and other dietary components in the maintenance of bone health and the progression of related diseases.
LAB: Vitamin K 1. Determine the amounts of individual dietary forms of vitamin K in nationally representative samples of frequently consumed U.S. foods and dietary supplements.
2. Characterize the effects of dietary and non-dietary factors, such as age, lipid profile and body fat, on the bioavailability and utilization of different forms of vitamin K in humans.
3. Identify mechanisms of action for vitamin K, other than its classic role as an enzyme cofactor, using cellular and animal models.
LAB: Vitamin K Laboratory analysis of different forms of vitamin K will be conducted in selected foods obtained through collaboration with the USDA Nutrient and Data Laboratory (NDL), as part of the Food and Nutrient Analysis Program. Priorities for food analysis will include dietary supplements, food purchased in family style restaurants, foods common to the Hispanic/Latino diet, and foods associated with high calorie diets. Food composition data will be transferred to the NDL for entry into national food composition databases. To identify dietary and non-dietary factors that determine how much vitamin K obtained from foods is utilized, we will apply stable isotope techniques to measures of vitamin K metabolism. Data obtained from ongoing metabolic studies in men and women, in addition to pilot feasibility studies, will be used to refine the study design to test the response of these measures to intake of different vitamin K-rich food sources. Animal models will be used to identify tissue-specific effects of interactions between vitamin K and other fat-soluble vitamins, with an emphasis on vitamins A and D. To identify mechanisms of action for vitamin K other than its classic role as an enzyme cofactor, urinary and serum levels of vitamin K metabolites will be measured in response to vitamin K supplementation using archived samples from human and animal studies. We will then focus on the role of different forms of vitamin K in inflammation through the inactivation of nuclear receptors in macrophages.
Looker, A.C., Dawson-Hughes, B., Tosteson, A.N., Johansson, H., Kanis, J.A., Melton Iii, J.L. 2011. Hip fracture risk in older US adults by treatment eligibility status based on new National Osteoporosis Foundation Guidance. Osteoporosis International. 22(2):541-549.
Bischoff-Ferrari, H.A., Shao, A., Dawson-Hughes, B., Hathcock, J., Giovannucci, E., Willett, W.C. 2010. Benefit-risk assessment of vitamin D supplementation. In: Reichrath,J., Editor. Osteoporosis International. Austin, TX: Landes Bioscience. p.55-71.
Bischoff-Ferrari, H., Dawson-Hughes, B., Baron, J.A., Kanis, J., Orav, E.J., Staehelin, H.B., Kiel, D.P., Henschkowski, J., Spiegelman, D., Li, R., Wong, J.B., Willett, W.C., Burckhardt, P. 2011. Milk intake and risk of hip fracture in men and women: a meta-analysis of prospective cohort studies. Journal of Bone and Mineral Research. 26(4):833-839.
Pittas, A.G., Dawson-Hughes, B. 2010. Vitamin D and diabetes. The Journal of Steroid Biochemistry and Molecular Biology. 121:425-429.
Inga, P., Crosier, M.D., Yoshida, M., Booth, S.L., Cupples, L., Dawson-Hughes, B., Karasik, D., Kiel, D.P., Lu, Z., Ordovas, J.M., Trikalinos, T.A. 2010. Associations of APOE gene polymorphisms with bone mineral density and fracture risk: a meta-analysis. Osteoporosis International. 198:1311-1315.
Pittas, A.G., Qi, S., Manson, J.E., Dawson-Hughes, B., Hu, F.B. 2010. Plasma 25-hydroxyvitamin D concentration and risk of type 2 diabetes in women. Diabetes Care. 33(9):2021-2023.
Al Rajabi, A., Peterson, J., Choi, S., Suttie, J., Barakat, S., Booth, S.L. 2010. Measurement of Menadione in urine by HPLC. Journal of Chromatography B. 878(26):2457-2460.
Kanis, J., Hans, D., Cooper, C., Baim, S., Bilezikian, J., Binkley, N., Cauley, J., Compston, J., Dawson-Hughes, B., Fuleihan, G. 2011. Interpretation and use of FRAX in clinical practice - position paper of the International Osteoporosis Foundation and the International Society for Clinical Densitometry. Osteoporosis International. 22:2395-2411.
Mitri, J., Dawson-Hughes, B., Hu, F., Pittas, A. 2011. The effects of vitamin D and calcium supplementation on pancreatic beta cell function, insulin sensitivity and glycemia in adults at high risk for diabetes. The CaDDM Randomized Controlled Trial. American Journal of Clinical Nutrition. 94(2):486-494.
Misra, D., Booth, S., Crosier, M., Ordovas, J., Felson, D., Neogi, T. 2011. Matrix Gla Protein polymorphism, but not concentrations, is associated with radiographic hand osteoarthritis. Journal of Rheumatology. DOI: 10.3899/jrheum.100985.
Dawson-Hughes, B., Looker, A.C., Tosteson, A.N., Johansson, H., Kanis, J.A., Melton, L. 2010. The potential impact of new National Osteoporosis Foundation guidance on treatment patterns. Osteoporosis International ; 21:41-52.
Kanis, J.A., Johansson, H., Oden, A., Dawson-Hughes, B., Meldton, L., Mccloskey, E.V. 2010. The effects of a FRAX revision for the US. Osteoporosis International. 21:35-40.
Durazo-Arvizu, R.A., Dawson-Hughes, B., Sempos, C.T., Yetley, E.A., Looker, A.C., Cao, G., Harris, S.S., Burt, V.L., Carriquiry, A.L., Picciano, M. 2010. Three-phase model harmonizes estimates of the maximal suppression of parathyroid hormone by 25-hydroxyvitamin D in persons 65 y of age and older. Journal of Nutrition. 140(3):595-596.
Dawson-Hughes, B., Looker, A., Tosteson, A., Johansson, H., Kanis, J., Melton, L. 2011. The potential impact of the National Osteoporosis Foundation guidance on treatment eligibility in the U.S.: an update in NHANES 2005-2008. Osteoporosis International. DOI: 10.1007/s00198-011-1694-y.
Harris, S., Dawson-Hughes, B. 2010. No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults. Endocrine Journal. 38(2):221-226.