Location: Animal Parasitic Diseases
Project Number: 1245-32000-096-02
Start Date: Jun 13, 2008
End Date: Jun 12, 2013
Neospora caninum antigens will be formulated with Pfizer adjuvants and used to immunize the mouse model (BALB/C) of neosporosis. Humoral (antibody response) and cell-mediated immunities (T cell and cytokine response) of the immunized mice will be determined in vitro. Due to recent changes in the research project objectives, the original Approach of this Trust Agreement has been updated to reflect the following: 1) Neospora caninum antigens will NOT be used in this research, and 2) nematode parasite antigens will be formulated in adjuvants (5-10 adjuvants favoring Th2 responses) produced by Pfizer, Inc., mice and small ruminants will be immunized and immune responses to nematode antigens will be characterized.