PREVENTION AND TREATMENT OF MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS (MAP) INFECTION IN MICE BY LACTOBACILLUS ACIDOPHILUS NP51
Project Number: 5030-32000-093-06
Start Date: Jul 09, 2008
End Date: Jun 30, 2011
1. To evaluate effects of Lactobacillus acidophilus NP51 on host immune response.
2. To evaluate effects of NP51 on the prevention of MAP infection.
3. To evaluate effects of NP51 on the treatment of MAP infection.
Mice will be fed NP51 before and after challenge with MAP to ascertain the effectiveness in prevention or treatment of the infection and colonization of target tissues such as spleen, ileum, and mesenteric lymph nodes. The host response to NP51 will be determined by evaluation of cytokine induction alone and in tandem with MAP infection.