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United States Department of Agriculture

Agricultural Research Service

Research Project: THE TOXICITY OF PYRROLIZIDINE ALKALOID-CONTAINING PLANTS AND OTHER HEPATOTOXIC AND NEUROTOXIC PLANTS

Location: Poisonous Plant Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Physiological and serum biochemical changes associated with rayless goldenrod (Isocoma pluriflora) poisoning in goats - (Peer Reviewed Journal)
Davis, T.Z., Green, B.T., Stegelmeier, B.L., Lee, S.T., Welch, K.D., Pfister, J.A. 2013. Physiological and serum biochemical changes associated with rayless goldenrod (Isocoma pluriflora) poisoning in goats. Toxicon. 76: 247-54.
Piperidine, pyridine alkaloid inhibition of fetal movement in a day 40 pregnant goat model - (Peer Reviewed Journal)
Green, B.T., Lee, S.T., Welch, K.D., Pfister, J.A., Panter, K.E. 2013. Piperidine, pyridine alkaloid inhibition of fetal movement in a day 40 pregnant goat model. Food and Chemical Toxicology. 58:8-13.
Identification of a lycopsamine-N-oxide chemotype of Amsinckia intermedia - (Peer Reviewed Journal)
Colegate, S.M., Gardner, D.R., Davis, T.Z., Welsh, S.L., Betz, J.M., Panter, K.E. 2013. Identification of a lycopsamine-N-oxide chemotype of Amsinckia intermedia. Biochemical Systematics and Ecology. 48: 132-5.
Addition of high concentration of inorganic selenium in orchardgrass (Dactylis glomerata L.) hay diet does not interfere with microbial fermentation in mixed ruminal microorganisms in continuous cultures - (Peer Reviewed Journal)
Eun, J., Davis, T.Z., Vera, J., Miller, D.N., Panter, K.E., Zobell, D. 2013. Addition of high concentration of inorganic selenium in orchardgrass (Dactylis glomerata L.) hay diet does not interfere with microbial fermentation in mixed ruminal microorganisms in continuous cultures. Professional Animal Scientist. 29(1): 39-45.
Dehydropyrrolizidine alkaloids in two Cryptantha species: Including two new open chain diesters one of which is amphoteric - (Peer Reviewed Journal)
Colegate, S.M., Gardner, D.R., Davis, T.Z., Betz, J.M., Panter, K.E. 2013. Dehydropyrrolizidine alkaloids in two Cryptantha species: Including two new open chain diesters one of which is amphoteric. Phytochemical Analysis. 24: 201-12.
A comparison of the metabolism of the abortifacient compounds from Ponderosa Pine needles in conditioned versus naive cattle     Reprint Icon - (Peer Reviewed Journal)
Welch, K.D., Gardner, D.R., Pfister, J.A., Panter, K.E., Zieglar, J., Hall, J. 2012. A comparison of the metabolism of the abortifacient compounds from Ponderosa Pine needles in conditioned versus naive cattle. Journal of Animal Science. 90(12): 4611-7.
The resolution of rayless goldenrod (Isocoma pluriflora) poisoning in goats - (Peer Reviewed Journal)
(31-May-12)
Evaluation of drying methods and toxicity of rayless goldenrod (Isocoma pluriflora) and white snakeroot (Ageratina altissima) in goats - (Peer Reviewed Journal)
Lee, S.T., Davis, T.Z., Cook, D., Stegelmeier, B.L. 2012. Evaluation of drying methods and toxicity of rayless goldenrod (Isocoma pluriflora) and white snakeroot (Ageratina altissima) in goats. Journal of Agricultural and Food Chemistry. 60(19): 4849-53.
Dietary exposure of livestock and humans to hepatotoxic natural products     Reprint Icon - (Book / Chapter)
Colegate, S.M., Stegelmeier, B.L., Edgar, J.A. 2012. Dietary exposure of livestock and humans to hepatotoxic natural products. In: Fink-Gremmels, J., editor. Animal Feed Contamination: Effects on Livestock and Food Safety. Philadelphia, PA: Woodhead Publishing Series in Food Sciences, Technology and Nutrition. p. 352-82.
Dehydropyrrolizidine alkaloids, including monoesters with an unusual esterifying acid, from cultivated Crotalaria juncea (Sunn Hemp cv. 'Tropic Sun') - (Peer Reviewed Journal)
Colegate, S.M., Gardner, D.R., Joy, R.J., Betz, J.M., Panter, K.E. 2012. Dehydropyrrolizidine alkaloids, including monoesters with an unusual esterifying acid, from cultivated Crotalaria juncea (Sunn Hemp cv. 'Tropic Sun'). Journal of Agricultural and Food Chemistry. 60: 3541-50.
Piperidine alkaloids: Human and food animal teratogens     Reprint Icon - (Peer Reviewed Journal)
Green, B.T., Lee, S.T., Panter, K.E., Brown, D.R. 2012. Piperidine alkaloids: Human and food animal teratogens. Food and Chemical Toxicology. 50(6): 2049-55.
Benzofuran ketone dosage-dependent rayless goldenrod (Isocoma pluriflora) toxicosis in a caprine model - (Peer Reviewed Journal)
(19-Jul-11)
Relative feeding and development of armyworm, Mythimna (Pseudaletia) unipuncta (Haworth), on switchgrass and corn, and its potential effects on switchgrass grown for biomass - (Peer Reviewed Journal)
Prasifka, J.R., Bradshaw, J.D., Lee, S.T., Gray, M.E. 2011. Relative feeding and development of armyworm, Mythimna (Pseudaletia) unipuncta (Haworth), on switchgrass and corn, and its potential effects on switchgrass grown for biomass. Journal of Economic Entomology. 104(5): 1561-7.
Targeted grazing: Applying the research to the land     Reprint Icon - (Peer Reviewed Journal)
Frost, R., Walker, J., Madsen, C., Holes, R., Lehfeldt, J., Cunningham, J., Voth, K., Welling, B., Davis, T.Z., Bradford, D., Malot, J., Sullivan, J. 2012. Targeted grazing: Applying the research to the land. Rangelands. 34(1): 2-10.
Development of a gas chromatography-mass spectrometry technique to diagnose white snakeroot (Ageratina altissima) poisoning in a cow - (Peer Reviewed Journal)
Meyerholtz, K.A., Burcham, G.N., Miller, M.A., Wilson, C.R., Hooser, S.B., Lee, S.T. 2011. Development of a gas chromatography-mass spectrometry technique to diagnose white snakeroot (Ageratina altissima) poisoning in a cow. Journal of Veterinary Diagnostic Investigation. 23:775-9.
Identifying plant poisoning in livestock: Diagnostic approaches and laboratory tests - (Peer Reviewed Journal)
Stegelmeier, B.L. 2011. Identifying plant poisoning in livestock: Diagnostic approaches and laboratory tests. Veterinary Clinics of North America. 27(2): 407-17.
Pyrrolizidine alkaloid-containing toxic plants (Scenecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium, and Echium spp.) - (Peer Reviewed Journal)
Stegelmeier, B.L. 2011. Pyrrolizidine alkaloid-containing toxic plants (Scenecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium, and Echium spp.). Veterinary Clinics of North America. 27(2):419-28.
Detection of high levels of pyrrolizidine-N-oxides in the endangered plant cryptantha crassipes (Terlingua creek cat's-eye)using HPLC-ESI-MS - (Peer Reviewed Journal)
Williams, M.T., Warnock, B.J., Betz, J.M., Beck, J.J., Gardner, D.R., Lee, S.T., Molyneux, R.J., Colegate, S.M. 2011. Detection of high levels of pyrrolizidine-N-oxides in the endangered plant cryptantha crassipes (Terlingua creek cat's-eye)using HPLC-ESI-MS. Phytochemical Analysis. 22(3): 532-540
Selenium reverses Pteridium aquilinum-induced immunotoxic effects - (Peer Reviewed Journal)
Latorre, A.O., Caniceiro, B.D., Wysocki, H.L., Haraguchi, M., Gardner, D.R., Gorniak, S.L. 2011. Selenium reverses Pteridium aquilinum-induced immunotoxic effects. Food and Chemical Toxicology. 49(2):464-70.
Tremetone and structurally related compounds in white snakeroot (Ageratina altissima): A plant associated with trembles and milk sickness - (Peer Reviewed Journal)
Lee, S.T., Davis, T.Z., Gardner, D.R., Colegate, S.M., Cook, D., Green, B.T., Meyerholtz, K.A., Wilson, C.R., Stegelmeier, B.L., Evans, T.J. 2010. Tremetone and structurally related compounds in white snakeroot (Ageratina altissima): A plant associated with trembles and milk sickness. Journal of Agricultural and Food Chemistry. 58(15):8560-65. DOI: 10.1021/jf1012456.
Conditioned aversion induced by Baccharis coridifolia in sheep and cattle - (Book / Chapter)
Almeida, M.B., Assis-Brasil, N.D., Schild, A.L., Riet-Correa, F., Pfister, J.A., Soares, M.P.S. 2011. Conditioned aversion induced by Baccharis coridifolia in sheep and cattle. In: Riet-Correa, F., Pfister, J., Schild, A.L., Wierenga, T., editors. Poisoning by Plants, Mycotoxins, and Related Toxins. Cambridge, MA: CAB International. p. 613-6.
Effects of Senna occidentalis seeds ingested during gestation on kid behavior - (Book / Chapter)
Barbosa-Ferreira, M., Pfister, J.A., Gotardo, A.T., Raspantini, P.C.F., Gorniak, S.L. 2011. Effects of Senna occidentalis seeds ingested during gestation on kid behavior. In: Riet-Correa, F., Pfister, J., Schild, A.L., Wierenga, T., editors. Poisoning by Plants, Mycotoxins, and Related Toxins. Cambridge, MA. CAB International. 40:264-9.
Measurement of steroidal saponins in Panicum and Brachiaria grasses in the USA and Brazil - (Book / Chapter)
Lee, S.T., Mitchell, R., Gardner, D.R., Tokarnia, C.H., Riet-Correa, F. 2011. Measurement of steroidal saponins in Panicum and Brachiaria grasses in the USA and Brazil. In: Riet-Correa, F., Pfister, J., Schild, A.L., Wierenga, T., editors. Poisoning by Plants, Mycotoxins, and Related Toxins. Cambridge,MA. CAB International. 20:142-4.
Seasonal variation in pyrrolizidine alkaloid concentration and plant development in Senecio madagascariensis poir. (Asteraceae) in Brazil - (Book / Chapter)
Karam, F.S.C., Haraguchi, M., Gardner, D.R. 2011. Seasonal variation in pyrrolizidine alkaloid concentration and plant development in Senecio madagascariensis poir. (Asteraceae) in Brazil. In: Riet-Correa, F., Pfister, J., Schild, A.L., Wierenga, T., editors. Poisoning by Plants, Mycotoxins, and Related Toxins. Cambridge, MA: CAB International. p. 179-85.
Experimemntal Rayless Goldenrod (Isocoma pluriflora) Toxicosis in Goats - (Peer Reviewed Journal)
Stegelmeier, B.L., Davis, T.Z., Green, B.T., Lee, S.T., Hall, J.O. 2010. Experimemntal Rayless Goldenrod (Isocoma pluriflora) Toxicosis in Goats. Journal of Veterinary Diagnostic Investigation 22:570-577.
Asexual endophytes in a native grass: Tradeoffs in mortality, growth, reproduction, and alkaloid production - (Peer Reviewed Journal)
Faeth, S.H., Hayes, C.J., Gardner, D.R. 2010. Asexual endophytes in a native grass: Tradeoffs in mortality, growth, reproduction, and alkaloid production. Microbial Ecology. 60:496-504. DOI: 10.1007/s00248-010-9643-4.
Buffalo calves intoxicated with Ageratum houstonianum mill - (Book / Chapter)
Pal, B.B., Singh, D.K., Stegelmeier, B.L. 2011. Buffalo calves intoxicated with Ageratum houstonianum mill. In: Riet-Correa, F., Pfister, J., Schild, A.L., Wierenga, T., editors. Poisoning by Plants, Mycotoxins, and Related Toxins. Cambridge, MA. CAB International. 27:186-9.
Baccharis pteronioides toxicity - (Book / Chapter)
Stegelmeier, B.L., Sani, Y., Pfister, J.A. 2011. Baccharis pteronioides toxicity. In: Riet-Correa, F., Pfister, J., Schild, A.L., Wierenga, T., editors. Poisoning by Plants, Mycotoxins, and Related Toxins. Cambridge, MA. CAB International. 72:433-6.
Asexual Endophytes and Associated Alkaloids Alter Arthropod Community Structure and Increase Herbivore Abundances on a Native Grass     Reprint Icon - (Peer Reviewed Journal)
Jani, A.J., Faeth, S.H., Gardner, D.R. 2010. Asexual Endophytes and Associated Alkaloids Alter Arthropod Community Structure and Increase Herbivore Abundances on a Native Grass. Ecology Letters. 13(1): 106-17.
Colic Caused by Panicum maximum Toxicosis in Equidae in Northern Brazil - (Peer Reviewed Journal)
Cerqueira, V.D., Riet-Correa, G., Barbosa, J.D., Duarte, M.D., Oliveira, C.M., De Oliverira, C.A., Tokarnia, C., Lee, S.T., Riet-Correa, F. 2009. Colic Caused by Panicum maximum Toxicosis in Equidae in Northern Brazil. Journal of Veterinary Diagnostic Investigation, 21:882-888
Bracken fern poisoning - (Book / Chapter)
Stegelmeier, B.L. 2010. Bracken fern poisoning. In: Kahn, C.M., Line, S., editors. Merck Veterinary Manual. 10th Edition. Rahway, N.J. Merck Publishing Group. p. 2670-2.
Sweet clover poisoning - (Book / Chapter)
Stegelmeier, B.L. 2010. Sweet clover poisoning. In: Kahn, C.M., Line, S., editors. Merck Veterinary Manual. Tenth Edition. Rahway, N.J. Merck Publishing Group. p.2731-2.
Baccharis Pteronioides Toxicity in Livestock and Hamsters.     Reprint Icon - (Peer Reviewed Journal)
Stegelmeier, B.L., Sani, Y., Pfister, J.A. 2009. Baccharis Pteronioides Toxicity in Livestock and Hamsters. Journal of Veterinary Diagnostic Investigation. 21:208-213
A Quantitative Method for the Measurement of Three Benzofuran Ketones in Rayless Goldenrod (Isocoma pluriflora) and White Snakeroot (Ageratine altissima) by HPLC - (Peer Reviewed Journal)
Lee, S.T., Davis, T.Z., Gardner, D.R., Stegelmeier, B.L., Evans, T.J. 2009. A Quantitative Method for the Measurement of Three Benzofuran Ketones in Rayless Goldenrod (Isocoma pluriflora) and White Snakeroot (Ageratine altissima) by HPLC. Journal of Agricultural and Food Chemistry. 57(12):5639-5642
Isolation, Characterization, and Quantification of Steroidal Saponins in Switchgrass (Panicum virgatum L.)     Reprint Icon - (Peer Reviewed Journal)
Lee, S.T., Mitchell, R., Wang, Z., Heiss, C., Gardner, D.R., Azadi, P. 2009. Isolation, Characterization, and Quantification of Steroidal Saponins in Switchgrass (Panicum virgatum L.). Journal of Agricultural and Food Chemistry. 57(6):2599-2604. DOI: 10.1021/jf803907y
Livestock Poisoning with Pyrrolizidine Alkaloid Containing Plants (Senecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium and Echium spp.)     Reprint Icon - (Peer Reviewed Journal)
Stegelmeier, B.L., Gardner, D.R., Davis, T.Z. 2009. Livestock Poisoning with Pyrrolizidine Alkaloid Containing Plants (Senecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium and Echium spp.). Rangelands. 31(1):25-37. http://www.bioone.org/doi/pdf/10.2111/1551-501X-31.1.45?
Identifying Plant Poisoning in Livestock     Reprint Icon - (Peer Reviewed Journal)
Stegelmeier, B.L., Green, B.T., Panter, K.E., Welch, K.D., Hall, J.O. 2009. Identifying Plant Poisoning in Livestock. Rangelands 31(1):5-9 http://www.bioone.org/doi/pdf/10.2111/1551-501X-31.1.45?
Selected Common Poisonous Plants of the United States' Rangelands     Reprint Icon - (Peer Reviewed Journal)
Davis, T.Z., Lee, S.T., Ralphs, M.H., Panter, K.E. 2009. Selected Common Poisonous Plants of the United States' Rangelands. Rangelands. 31(1):38-44 DOI:10.2111/1551-501X-31.1.38
Value of Plant Diversity for Diet Mixing and Sequencing in Herbivores     Reprint Icon - (Peer Reviewed Journal)
Provenza, F.D., Villalba, J.J., Wiedmeier, R.W., Layman, T., Owens, J., Lisonbee, L., Clemensen, A., Welch, K.D., Gardner, D.R., Lee, S.T. 2009. Value of Plant Diversity for Diet Mixing and Sequencing in Herbivores. Rangelands. 31(1):45-49. DOI:10.2111/1551-501X-31.1.45
Conditioned Aversion in Sheep Induced by Baccharis coridifolia     Reprint Icon - (Peer Reviewed Journal)
De Almeida, M.B., Schild, A.L., Brasil, N.D., Quevedo, P., Fiss, L., Pfister, J.A., Riet-Correa, F. 2009. Conditioned Aversion in Sheep Induced by Baccharis coridifolia. Applied Animal Behaviour Science. 117:197-200 DOI: 10.1016/japplanim.2008.12.006
Steroselective Potencies and Relative Toxicities of Coniine Enantiomers - (Peer Reviewed Journal)
Lee, S.T., Green, B.T., Welch, K.D., Pfister, J.A., Panter, K.E. 2008. Steroselective Potencies and Relative Toxicities of Coniine Enantiomers. Chemical Research in Toxicology. 21(10): 2061-2064. DOI 10.1021/tx800229w
Separation and Measurement of Plant Alkaloid Enantiomers by RP-HPLC Analysis of their Fmoc-Alanine Analogs     Reprint Icon - (Peer Reviewed Journal)
Lee, S.T., Gardner, D.R., Chang, C.T., Panter, K.E., Molyneux, R.J. 2008. Separation and Measurement of Plant Alkaloid Enantiomers by RP-HPLC Analysis of their Fmoc-Alanine Analogs. Phytochemical Analysis, 19:395-402. DOI: 10.1002/pca.1064.
Last Modified: 8/27/2014
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