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United States Department of Agriculture

Agricultural Research Service

Research Project: DETERMINANTS OF AVIAN COCCIDIOSIS INFECTION AND PATHOGENICITY Project Number: 1265-31320-075-00
Project Type: Appropriated

Start Date: Mar 12, 2008
End Date: Oct 10, 2011

Objective:
Identify host genetic variations associated with disease susceptibility to avian coccidiosis and Clostridium infection. -Component 6: Problem Statement 6A Discover biological determinants that can be used to understand genetic diversity in strains and species of avian coccidia as a tool for more precise application of controls. -Component 6: Problem Statement 6A Discover biological responses of the chicken to Eimeria spp. and Clostridium spp. in order to implement controls of dual infections. -Component 6: Problem Statement 6A

Approach:
Obtain nucleic acid sequences from Eimeria species that have different phenotypic characteristics, such as infection and virulence, and identify genes or functional mutations associated with these variances. Using molecular methods that can identify gene sequences that are expressed during the various stages of Eimeria development, upregulated during intracellular development, or are associated with parasite-host interactions. Study the functions of these expressed gene products in parasite development and determine parasite factors that are associated with immune evasion or induction of protective immunity. Conduct studies on antigenic variation and drug resistance in Eimeria with the goal of developing genetic markers for these traits. BL2N 7/2/10; BL1 1/25/11

Last Modified: 10/25/2014
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