2010 Annual Report
Sub-objective 1.A: Identify physiological pathways that underlie the relationship between reproductive losses due to seasonal infertility. Sub-objective 1.B: Identify changes in adipose tissue gene expression underlying variation in seasonal infertility in swine.
Objective 2: Define physiological factors contributing to gastrointestinal-microbial population and immune function that are associated with seasonal infertility in sows.
Sub-objective 2.A: Identify microbial popoulation changes and sensitivity to antimicrobials associated with seasonal infertility. Sub-objective 2.B: Characterize functional changes in systemic and tissue level inflammatory and immune cells that are associated with seasonal infertility in the sow.
Objective 3: Determine if a relationship exists between reproductive losses due to seasonal infertility and adipocyte function, metabolism and uterine function.
Sub-objective 3.A: Identify genes that are related to physiological pathways that are associated with seasonal infertility and associated adipocyte function and metabolism. Sub-objective 3.B: Identify genes that are related to physiological pathways that are associated with seasonal infertility and pregnancy failure.
Objective 4: To map patterns of gene expression that underlie adipose tissue deposition and identify intervention control points to reduce fat deposition.
Barb, C.R., Hausman, G.J., Lents, C.A., Lkhagvadorj, S., Qu, L., Cai, W., Couture, L., Wang, L., Rekaya, R., Nettleton, D. 2010. Gene expression in hypothalamus, liver and adipose tissues and food intake reponse to melanocortin-4 receptor (MC4R) agonist in pigs expressing MC4R mutations. Physiological Genomics. 41:254-268.
Lkhagvadorj, S., Qu, L., Cai, W., Couture, L., Barb, C.R., Hausman, G.J., Netteton, D., Anderson, L., Deckers, J., Tuggle, C. 2010. Gene expression profiling of the short-term adaptive response to acute caloric restriction in liver and adipose tissues of pigs differing in feed efficiency. American Journal of Physiology. 298:R494-R507.
Poulos, S.P., Hausman, D.B., Hausman, G.J. 2009. The development and endocrine functions of adipose tissue. Molecular and Cellular Endocrinology.
Hausman, G.J., Barb, C.R. 2010. Adipose tissue and the reproductive axis: biological aspects. Book Chapter. 19:31-44.