Publications (Clicking on the reprint icon will take you to the publication reprint.)

An alternate delivery system improves vaccine performance against foot-and-mouth disease virus (FMDV)     - (Peer Reviewed Journal)

Pandya, M., Pacheco Tobin, J., Bishop, E.A., Kenney, M.A., Milward, F., Doel, T., Golde, W.T. 2012. An alternate delivery system improves vaccine performance against foot-and-mouth disease virus (FMDV). Vaccine. 30(20):3106-3111.

Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle     - (Peer Reviewed Journal)

Perez-Martin, E., Weiss, M., Diaz San Segundo, F.C., Pacheco Tobin, J., Arzt, J., Grubman, M.J., De Los Santos, T.B. 2012. Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle. Journal of Virology. 86(8):4477-4487.

Effects of interferon-alpha on the immune response to porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)

(01-Jan-12)

Early detection and visualization of human adenovirus serotype 5-viral vectors carrying foot-and-mouth disease virus or luciferase transgenes in cell lines and bovine tissues     - (Peer Reviewed Journal)

Montiel, N., Smoliga, G.R., Arzt, J. 2012. Early detection and visualization of human adenovirus serotype 5-viral vectors carrying foot-and-mouth disease virus or luciferase transgenes in cell lines and bovine tissues. Vaccine. 30(9):1690-1701.

Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease     - (Peer Reviewed Journal)

Diaz San Segundo, F.C., Weiss, M., Perez-Martin, E., Dias, C.C., Grubman, M.J., De Los Santos, T.B. 2012. Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease. Journal of Virology. 86(3):1316-1327.

Increased efficacy of an adenovirus-vectored foot-and-mouth disease capsid subunit vaccine expressing nonstructural protein 2B is associated with a specific T cell response     - (Peer Reviewed Journal)

Moraes, M.P., Diaz San Segundo, F.C., Dias, C.C., Pena, L., Grubman, M.J. 2011. Increased efficacy of an adenovirus-vectored foot-and-mouth disease capsid subunit vaccine expressing nonstructural protein 2B is associated with a specific T cell response. Vaccine. 29(51):9431-9440.

Antiviral activity of bovine type III interferon against foot-and-mouth disease virus - (Peer Reviewed Journal)

Diaz-San Segundo, F., Weiss, M., Perez-Martin, E., Koster, M.J., Zhu, J.J., Grubman, M.J., De Los Santos, T.B. 2011. Antiviral activity of bovine type III interferon against foot-and-mouth disease virus. Virology. 413(2):283-292.

Evidence of activation and suppression during the early immune response to foot-and-mouth disease virus - (Review Article)

Golde, W.T., De Los Santos, T.B., Robinson, L., Grubman, M.J., Sevilla, N., Summerfield, A. 2011. Evidence of activation and suppression during the early immune response to foot-and-mouth disease virus. Transboundary and Emerging Diseases. 58(4):283-290.

Custom-engineered chimeric foot-and-mouth disease vaccine elicits protective immune responses in pigs - (Peer Reviewed Journal)

Blignaut, B., Visser, N., Theron, J., Rieder, A.E., Maree, F.F. 2011. Custom-engineered chimeric foot-and-mouth disease vaccine elicits protective immune responses in pigs. Journal of General Virology. 92(4):849-859.

Induction of foot-and-mouth disease virus specific cytotoxic T cell killing by vaccination - (Peer Reviewed Journal)

Patch, J.R., Pederesen, L.E., Moraes, M.P., Grubman, M.J., Nielsen, M., Buus, S., Golde, W.T. 2011. Induction of foot-and-mouth disease virus specific cytotoxic T cell killing by vaccination. Clinical and Vaccine Immunology. 18(2):280-288.

Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus - (Peer Reviewed Journal)

Reeve, R., Blignaut, B., Esterhuysen, J.J., Opperman, P., Matthews, L., Fry, E., De Beer, T.A., Theron, J., Rieder, A.E., Vosloo, W., O'Neill, H.G., Haydon, D.T., Maree, F.F. 2010. Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus. PLoS Computational Biology. DOI: 10.1371/journal.pcbi.1001027.

Marked differences between MARC-145 cells and swine alveolar macrophages in IFN beta-induced activation of antiviral state against PRRSV - (Peer Reviewed Journal)

He, D., Overend, C., Ambrogio, J., Magant, R.J., Grubman, M.J., Garmendia, A.E. 2010. Marked differences between MARC-145 cells and swine alveolar macrophages in IFN beta-induced activation of antiviral state against PRRSV. Veterinary Immunology and Immunopathology. Available: www.elsevier.com/locate/vetimm.2010.07.023.

Porcine type I interferon rapidly protects swine against challenge with multiple serotypes of foot-and-mouth disease virus - (Peer Reviewed Journal)

Dias, C.C., Moraes, M.P., Diaz-San Segundo, F., De Los Santos, T.B., Grubman, M.J. 2011. Porcine type I interferon rapidly protects swine against challenge with multiple serotypes of foot-and-mouth disease virus. Journal of Interferon and Cytokine Research. 31(2):227-236.

IgA antibody response of swine to foot-and-mouth disease virus infection and vaccination     - (Review Article)

Pacheco Tobin, J., Butler, J.E., Jew, J., Ferman, G., Zhu, J.J., Golde, W.T. 2010. IgA antibody response of swine to foot-and-mouth disease virus infection and vaccination. Clinical and Vaccine Immunology. p. 550-558.

IgA antibody response of swine to foot-and-mouth disease virus (FMDV) infection and vaccination - (Peer Reviewed Journal)

Pacheco Tobin, J., Butler, J.E., Jew, J., Ferman, G.S., Zhu, J.J., Golde, W.T. 2010. IgA antibody response of swine to foot-and-mouth disease virus (FMDV) infection and vaccination. Clinical and Vaccine Immunology. 17(4):550-558.

Interferon induced protection against foot-and-mouth disease virus correlates with enhanced tissue specific innate immune cell infiltration and interferon stimulated gene expression - (Peer Reviewed Journal)

Diaz-San Segundo, F., Moraes, M.P., De Los Santos, T.B., Dias, C., Grubman, M.J. 2010. Interferon induced protection against foot-and-mouth disease virus correlates with enhanced tissue specific innate immune cell infiltration and interferon stimulated gene expression. Journal of Virology. 84:2063-2077.

Adenovirus serotype 5 vectored foot-and-mouth disease subunit vaccines: the first decade     - (Peer Reviewed Journal)

Grubman, M.J., Moraes, M.P., Neilan, J., Ettyreddy, D., Butman, B.T., Brough, D.E., Brake, D.A. 2010. Adenovirus serotype 5 vectored foot-and-mouth disease subunit vaccines: the first decade. Future Virology. 5(1):51-64.

Foot-and-mouth disease - (Book / Chapter)

Grubman, M.J., Rodriguez, L.L., De Los Santos, T.B. 2010. Foot-and-mouth disease. In: Ehrenfeld, E., Domingo, E., Roos, R.P., editors. The Picornaviruses. Washington, DC: ASM Press. p. 397-410.

Innate Immune Defenses Induced by CpG do not Promote Vaccine-Induced Protection Against Foot-and-Mouth Disease in Pigs - (Peer Reviewed Journal)

Alves, M.P., Guzylack-Piriou, L., Juillard, V., Audonnet, J.C., Doel, T., Dawson, H.D., Golde, W.T., Gerber, H., Peduto, N., Mccullough, K.C., Summerfield, A. 2009. Innate Immune Defenses Induced by CpG do not Promote Vaccine-Induced Protection Against Foot-and-Mouth Disease in Pigs. Clinical and Vaccine Immunology. 16(8):1151-1157.

Adenoviral-based foot-and-mouth disease virus vaccine: effect of duration of antigen expression on immunogenicity in swine - (Abstract Only)

Dias, C., Moraes, M.P., Koster, M.J., Grubman, M.J. 2009. Adenoviral-based foot-and-mouth disease virus vaccine: effect of duration of antigen expression on expression on immunogenicity in swine. American Society for Virology Meeting. Paper No. Paper No. 13-18: P. 282.

Functional genomics approach to understand the role of Lpro in FMDV virulence - (Abstract Only)

De Los Santos, T.B., Grubman, M.J., Zhu, J.J. 2009. Functional genomics approach to understand the role of Lpro in FMDV virulence. American Society for Virology Meeting. Paper No. 9-21: P.262.

Examing the mechanisms of interferon-induced protection against foot-and-mouth disease virus in swine - (Abstract Only)

Diaz-San Segundo, F., Moraes, M.P., De Los Santos, T.B., Koster, M.J., Dias, C., Grubman, M.J. 2009. Examing the mechanisms of interferon-induced protection against foot-and-mouth disease virus in swine. American Society for Virology Meeting. Paper No. W21-5: p. 133.

Exploring the role of the lab protein of Foot-and-Mouth Disease Virus (FMDV) during viral infection - (Abstract Only)

De Los Santos, T.B., Piccone, M.E., Diaz-San Segundo, F., Pauszek, S.J., Kramer, E.V., Rodriguez, L.L. 2009. Exploring the role of the lab protein of Foot-and-Mouth Disease Virus (FMDV) during viral Infection. American Society for Virology Meeting. Paper No. 32-7: p. 337.

Adenoviral-based foot-and-mouth disease virus vaccine: evaluation of new vectors expressing serotype O in bovines - (Abstract Only)

Moraes, M.P., Diaz San-Segundo, F., Pena, L.J., Grubman, M.J. 2009. Adenoviral-based foot-and-mouth disease virus vaccine: evaluation of new vectors expressing serotype O in bovines. American Society for Virology Meeting. Paper No. W48-10: p. 211.

Accessory Cell Mediated Activation of Porcine NK Cells by TLR7 and TLR8 Agonists - (Peer Reviewed Journal)

Toka, F.N., Nfon, C., Dawson, H.D., Golde, W.T. 2009. Accessory Cell Mediated Activation of Porcine NK Cells by TLR7 and TLR8 Agonists. Clinical and Vaccine Immunology.Vol.16. No. 6.: 866-878.

A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Sub-Cellular Localization and Function - (Peer Reviewed Journal)

De Los Santos, T.B., Diaz-San Segundo, F., Zhu, J.J., Koster, M.J., Dias, C., Grubman, M.J. 2008. A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Sub-Cellular Localization and Function. Journal of Virology. 83(4):1800-1810.

Role of IL-10 during Foot-and-Mouth Disease Virus (FMDV) Infection and Its Potential Use as Immunomodulator - (Abstract Only)

(01-Oct-08)

Deceptive Imprinting and Immune Refocusing in Vaccine Design - (Peer Reviewed Journal)

Tobin, G.J., Trujillo, J.D., Bushnell, R.V., George, L., Chaudhuri, A., Long, J., Barrera, J., Pena, L., Grubman, M.J., Nara, P.L. 2008. Deceptive Imprinting and Immune Refocusing in Vaccine Design. Vaccine. 26:6189-6199.

Delivery of a Foot-and-Mouth Disease Virus Empty Capsid Subunit Antigen with Nonstructural Protein 2B Improves Protection of Swine - (Peer Reviewed Journal)

Pena, L., Moraes, M., Koster, M.J., Burrage, T., Pacheco Tobin, J., Diaz San-Segundo, F., Grubman, M.J. 2008. Delivery of a Foot-and-Mouth Disease Virus Empty Capsid Subunit Antigen with Nonstructural Protein 2B Improves Protection of Swine. Vaccine. 26:5689-5699.

Langerhans Cells in Porcine Skin - (Peer Reviewed Journal)

Nfon, C.K., Toka, F.N., Dawson, H., Golde, W.T. 2008. Langerhans Cells in Porcine Skin. Veterinary Immunology and Immunopathology. 126:236-247.

Heparan Sulfate-Binding Foot-and-Mouth Disease Virus Enters Cells Via Caveolae-Mediated Endocytosis - (Peer Reviewed Journal)

(03-May-08)

Cellular Changes Induced by Adenovirus Vaccine Vectors Expressing Foot-and-Mouth Disease Virus Structural and Nonstructural Proteins - (Abstract Only)

Moraes, M., O'Donnell, V.K., Burrage, T.G., Pena, L., Diaz-San Segundo, F., Koster, M.J., Zhu, J., Grubman, M.J. 2008. Cellular Changes Induced by Adenovirus Vaccine Vectors Expressing Foot-and-Mouth Disease Virus Structural and Nonstructural Proteins. European Study Group on the Molecular Biology of Picornaviruses. P 203

Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus - (Abstract Only)

Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Dawson, H., Golde, W.T., Grubman, M.J. 2008. Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus. European Study Group on the Molecular Biology of Picornaviruses. P 149

Suppression of Swine NK Cell Function During Acute Infection with Foot-and-Mouth Disease Virus (FMDV) - (Abstract Only)

Toka, F., Nfon, C.K., Golde, W.T. 2008. Suppression of Swine NK Cell Function During Acute Infection with Foot-and-Mouth Disease Virus (FMDV). European Study Group on the Molecular Biology of Picornaviruses. P 94

A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Subcellular Localization and Function - (Abstract Only)

De Los Santos, T., San Segundo-Diaz, F., Zhu, J., Koster, M.J., Grubman, M.J. 2008. A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. European Study Group on the Molecular Biology of Picornaviruses. P 86

Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen - (Peer Reviewed Journal)

Grubman, M.J., Moraes, M., Diaz-San Segundo, F., Pena, L., De Los Santos, T. 2008. Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen. Federation of European Microbiological Societies Microbiology Letters. 53:8-17.