Start Date: Nov 07, 2006
End Date: Oct 05, 2011
Within Objective 1 unique antigens of M. paratuberculosis will be evaluated as immunogens with particular emphasis on their utility as diagnostic reagents or vaccine candidates. Objective 2 will compare and contrast the genetic content of various strains of M. paratuberculosis, both within and between species of animals to provide information on the characteristics of infectivity and pathogenicity for different strains. The host immune response to M. paratuberculosis infection will be evaluated in Objective 3 in both experimentally and naturally infected animals to gain an understanding of how the disease progresses from a subclinical to a more clinical state. Objective 4 will examine the efficacy of skin testing and a blood assay for the early detection of disease in naturally infected and noninfected cattle and sheep. BSL-2; Recertified October 15, 2010 (IBC-0092). BSL-Exempt; Recertified October 15, 2010 (IBC-0238). BSL-Exempt; Recertified August 3, 2010 (IBC-0261).