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United States Department of Agriculture

Agricultural Research Service

Research Project: NUTRITION, CARDIOVASCULAR HEALTH, AND GENOMICS Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Gene expression changes in peripheral blood mononuclear cells from patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil - (Peer Reviewed Journal)
Camargo, A., Ruano, J., Fernandez, J.M., Parnell, L.D., Jimenez, A., Santos-Gonzalez, M., Marin, C., Perez-Martinez, P., Uceda, M., Lopez-Miranda, J., Perez-Jimenez, F. 2010. Gene expression changes in peripheral blood mononuclear cells from patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. Biomed Central (BMC) Genomics. 11:253-267.
Clock Genetic Variation and Metabolic Syndrome Risk: Modulation by Monounsaturated Fatty Acids - (Peer Reviewed Journal)
Garaulet, M., Lee, Y., Shen, J., Parnell, L.D., Arnett, D.K., Tsai, M.Y., Lai, C., Ordovas, J.M. 2009. CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. American Journal of Clinical Nutrition. 90(6):1466-1475.
Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors - (Peer Reviewed Journal)
Garaulet, M., Lee, Y., Shen, J., Parnell, L.D., Arnett, D.K., Tsai, M.Y., Lai, C., Ordovas, J.M. 2009. Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors. Human Molecular Genetics. 18(3):364-369.
Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites - (Peer Reviewed Journal)
Mattei, J., Parnell, L.D., Lai, C., Garcia-Bailo, B., Adiconis, X., Shen, J., Arnett, D., Demissie, S., Tucker, K., Ordovas, J.M. 2009. Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites. BioMed Central (BMC) Genetics. 10:45.
Apoa2, Dietary Fat and Body Mass Index: Replication of a Gene-Diet Interaction in Three Independent Populations - (Peer Reviewed Journal)
Corella, D., Peloso, G., Arnett, D.K., Demissie, S., Cupples, L., Tucker, K., Lai, C., Parnell, L.D., Coltell, O., Lee, Y., Ordovas, J.M. 2009. APOA2, dietary fat and body mass index: replication of a gene-diet interaction in three independent populations. Archives of Internal Medicine. 169:1897-1906.
Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men - (Peer Reviewed Journal)
Delgado-Lista, J., Perez-Jimenez, F., Ruano, J., Perez-Martinez, P., Fuentes, F., Criado-Garcia, J., Parnell, L.D., Ordovas, J.M., Lopez-Miranda, J. 2009. Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men. Journal of Lipid Research. 51:63-73.
Adam17_i33780a>g Polymorphism Interacts with Dietary N-6 Polyunsaturated Fatty Acids to Modulate Obesity Risk in the Genetics of Lipid Lowering Drugs and Diet Network Study - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2010. ADAM17_i33780A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the genetics of lipid lowering drugs and diet network study. Nutrition Metabolism and Cardiovascular Disease. 20(101):698-705.
Novel variants at KCTD10 and MVK/MMAB genes interact with dietary carbohydrates to modulate HDL-C concentrations in the genetics of lipid lowering drugs and diet network study - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. Novel variants at KCTD10 and MVK/MMAB genes interact with dietary carbohydrates to modulate HDL-C concentrations in the genetics of lipid lowering drugs and diet network study. American Journal of Clinical Nutrition. 90(3):686-694.
Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2010. Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin. Obesity. 18(2):327-332.
The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Tucker, K.L., Lane, J.M., Mattei, J., Smith, C., Parnell, L.D., Lai, C., Ordovas, J.M. 2009. The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease. 18:64-69.
Apolipoprotein C3 polymorphism is associated with cognitive function in Caribbean Hispanics - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Scott, T.M., Van Rompay, M., Parnell, L.D., Lai, C., Mattei, J., Junyent, M., Lee, Y., Garcia-Bailo, B., Ordovas, J.M. 2009. Apolipoprotein C3 polymorphism is associated with cognitive function in Caribbean Hispanics. PLoS One. 4(5):e5465.
A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Parnell, L.D., Lai, C., Ordovas, J.M., Tucker, K.L., Shen, J., Mattei, J., Smith, C., Lee, Y. 2009. A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease.20(3):157-167.
Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study - (Peer Reviewed Journal)
Smith, C.E., Arnett, D.K., Tsai, M.Y., Lai, C., Parnell, L.D., Shen, J., Laclaustra, M., Junyent, M., Ordovas, J.M. 2009. Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study. Atherosclerosis.206:500-504.
The effect of a novel intergenic polymorphism (rs11774572) on HDL cholesterol concentrations depends on the TaqIB polymorphism in the cholesterol ester transfer protein gene - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Shen, J., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. The effect of a novel intergenic polymorphism (rs11774572) on HDL cholesterol concentrations depends on the TaqIB polymorphism in the cholesterol ester transfer protein gene. Nutrition Metabolism and Cardiovascular Disease.20:34-40.
Genetic Variants at the PDZ-Interacting Domain of the Scavenger Receptor Class B Type I Interact with Diet to Influence the Risk of Metabolic Syndrome in Obese Men and Women - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Shen, J., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. Genetic Variants at the PDZ-Interacting Domain of the Scavenger Receptor Class B Type I Interact with Diet to Influence the Risk of Metabolic Syndrome in Obese Men and Women. Journal of Nutrition. 139(6):842-848.
The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: association with plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary artery disease - (Peer Reviewed Journal)
Jang, Y., Paik, J., Hyun, Y., Chae, J., Kim, J., Choi, J., Lee, S., Shin, D., Ordovas, J., Lee, J. 2009. The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: association with plasma APOA5 and serum triglyceride concentrations, LDL particle size and coronary artery disease. Clinica Chimica Acta. 402(1-2):83-87.
Association of apolipoprotein A5 concentration with serum insulin and triglyceride levels and coronary artery disease in Korean men - (Peer Reviewed Journal)
Hyun, Y., Jang, Y., Chae, J., Kim, J., Paik, J., Kim, S., Yang, J., Ordovas, J., Ko, Y., Lee, J. 2009. Association of apolipoprotein A5 concentration with serum insulin and triglyceride levels and coronary artery disease in Korean men. Atherosclerosis. 205(2):568-573.
Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia - (Peer Reviewed Journal)
Warodomwichit, D., Arnett, D.K., Kabagambe, E.K., Tsai, M.Y., Hixson, J.E., Straka, R.J., Province, M., An, P., Lai, C., Borecki, I., Ordovas, J. 2009. Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia. Journal of Nutrition. 139:439-446.
Common variants at 30 loci contribute to polygenic dyslipidemia - (Peer Reviewed Journal)
Kathiresan, S., Willer, C., Peloso, G., Demissie, S., Musunuru, K., Schadt, E., Kaplan, L., Bennett, D., Li, Y., Tanaka, T., Voight, B., Bonnycastle, L., Jackson, A., Crawford, G., Surti, A., Guiducci, C., Burtt, N., Parish, S., Clarke, R., Zelenika, D., Kubalanza, K., Morken, M., Scott, L., Stringham, H., Galan, P., Swift, A., Kuusisto, J., Bergman, R., Sundvall, J., Laakso, M., Ferrucci, L., Scheet, P., Sanna, S., Uda, M., Yang, Q., Lunetta, K., Dupius, J., De Bakker, P., O'Donnell, C., Scuteri, A., Schlessinger, D., Tuomilehto, J., Collins, F., Groop, L., Altshuler, D., Collins, R., Lathrop, G., Melander, O., Saloma, V., Peltonen, L., Orho-Melander, M., Ordovas, J., Boehnke, M., Abecasis, G., Mohlke, K., Cupples, A. 2009. Common variants at 30 loci contribute to polygenic dyslipidemia. Nature Genetics. 41:56-65.
Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states - (Peer Reviewed Journal)
Perez-Martinez, P., Corella, D., Shen, J., Arnett, D.K., Yiannakouris, N., Tai, E., Orho-Melander, M., Tucker, K.L., Tsai, M., Straka, R.J., Province, M., Kai, C., Perez-Jimenez, F., Lai, C., Lopez-Miranda, J., Guillen, M., Parnell, L.D., Borecki, I., Kathiresan, S., Ordovas, J.M. 2009. Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. American Journal of Clinical Nutrition. 89:391-399.
Effects of Perilipin (PLIN) gene variation on metabolic syndrome risk and weight-loss in obese children and adolescents - (Peer Reviewed Journal)
Deram, S., Nicolau, C.Y., Perez-Martinez, P., Guazzelli, I., Halpern, A., Wajchenberg, B.L., Ordovas, J.M., Villares, S.M. 2008. Effects of Perilipin (PLIN) gene variation on metabolic syndrome risk and weight-loss in obese children and adolescents. Journal of Clinical Endocrinology and Metabolism. 93:4933-4940.
Adipoq Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: the Goldn Study - (Peer Reviewed Journal)
Warodomwichit, D., Shen, J., Arnett, D., Tsai, M., Kabagambe, E., Peacock, J., Hixson, J., Straka, R., Province, M., An, P., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2009. ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study. Obesity. 17:510-517.
Smoking, inflammatory patterns, and postprandial hypertriglyceridemia - (Peer Reviewed Journal)
Kabagambe, E.K., Ordovas, J.M., Tsai, M.Y., Borecki, I.B., Hopkins, P.N., Arnett, D.K. 2009. Smoking, inflammatory patterns, and postprandial hypertriglyceridemia. Atherosclerosis. 203(2):633-639.
A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations - (Peer Reviewed Journal)
Orho-Melander, M., Melander, O., Guiducci, C., Perez-Martinez, P., Corella, D., Roos, C., Tewhey, R., Rieder, M.J., Hall, J., Abecasis, G., Tai, E., Welch, C., Arnett, D.K., Lyssenko, V., Lindholm, E., Saxena, R., De Bakker, P., Burtt, N., Voight, B.F., Hirschhorn, J.N., Tucker, K., Hedner, T., Tuomi, T., Isomaa, B., Eriksson, K., Taskinen, M., Wahlstrand, B., Hughes, T.E., Parnell, L.D., Lai, C., Berglund, G., Peltonen, L., Vartiainen, E., Jousilahti, P., Havulinna, A.S., Salomaa, V., Nilsson, P., Groop, L., Altshuler, D., Ordovas, J.M., Kathiresan, S. 2008. A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations. Diabetes. 57:3112-3121.
Gene–Environment Interactions and Susceptibility to Metabolic Syndrome and Other Chronic Diseases - (Review Article)
Ordovas, J.M., Shen, J. 2008. Gene–Environment Interactions and Susceptibility to Metabolic Syndrome and Other Chronic Diseases. Journal of Periodontology. 79(8S):1508-1513.
The challenges of molecular nutrition research 1- Linking genotype to healthy nutrition - (Review Article)
Williams, C.M., Ordovas, J.M., Lairon, D., Hesketh, J., Lietz, G., Gibney, M., Van Ommen, B. 2008. The challenges of molecular nutrition research 1- Linking genotype to healthy nutrition. Genes and Nutrition. 3(2):41–49.
Adiponectin Gene Variants are Associated with Insulin Sensitivity in Response to Dietary Fat Consumption in Caucasian Men - (Peer Reviewed Journal)
Perez-Martinez, P., Lopez-Miranda, J., Cruz-Teno, C., Delgado-Lista, J., Jimenez-Gomez, Y., Fernandez, J.M., Gomez, M.J., Marin, C., Perez-Jimenez, F., Ordovas, J.M. 2008. Adiponectin Gene Variants are Associated with Insulin Sensitivity in Response to Dietary Fat Consumption in Caucasian Men. Journal of Nutrition. 138(9):1609-1614.
Influence of genetic factors in the modulation of postprandial lipemia - (Review Article)
Perez-Martinez, P., Lopez-Miranda, J., Perez-Jimenez, F., Ordovas, J.M. 2008. Influence of genetic factors in the modulation of postprandial lipemia. Atherosclerosis Supplements. 9:49-55.
The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Perez-Martinez, P., Parnell, L.D., Peacock, J.M., Hixson, J.E., Tsai, M.Y., Lai, C., Straka, R.J., Hopkins, P.N., Ordovas, J.M. 2008. The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study. Journal of Lipid Research. 49:1839-1845.
Clinical significance of apolipoprotein A5 - (Review Article)
Tai, E., Ordovas, J.M. 2008. Clinical significance of apolipoprotein A5. Current Opinion in Lipidology. 19(4):349-354.
Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Parnell, L.D., Peacock, J.M., Lai, C., Hixson, J.E., Tsai, M.Y., Province, M., Straka, R.J., Ordovas, J.M. 2008. Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study. Diabetes Care. 31(5):910-915.
Why study gene-environment interactions? - (Review Article)
Ordovas, J., Tai, E. 2009. Why study gene-environment interactions?. Current Opinion in Lipidology. 19(2):158-167.
The genetic architecture of fasting plasma triglyceride response to fenofibrate treatment - (Peer Reviewed Journal)
Ordovas, J.M., Smith, J., Arnett, D., Kelly, R., Sun, Y., Hopkins, P., Hixson, J., Straka, R., Peacock, J., Kardia, S. 2008. The genetic architecture of fasting plasma triglyceride response to fenofibrate treatment. European Journal of Human Genetics. 16(5):603-613.
Estimating interaction between genetic and environmental risk factors efficiency of sampling designs within a cohort - (Peer Reviewed Journal)
Bureau, A., Diallo, M.S., Ordovas, J.M., Cupples, L.A. 2008. Estimating interaction between genetic and environmental risk factors efficiency of sampling designs within a cohort. Epidemiology. 19(1):83-93.
Nutrition in the genomics era: Cardiovascular disease risk and the Mediterranean diet - (Review Article)
Ordovas, J.M., Kaput, J., Corella, D. 2007. Nutrition in the genomics era: Cardiovascular disease risk and the Mediterranean diet. Molecular Nutrition and Food Research. 51(10):1293-9.
Last Modified: 11/26/2014
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