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Research Project:
GENOMIC STRATEGIES FOR CONTROL OF MAREK'S DISEASE VIRUS
Location: Endemic Poultry Viral Diseases Research Unit
Publications
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Comparative full genome analysis of four infectious laryngotracheitis virus (gallid herpesvirus-1) virulent isolates from the United States
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| Spatz, S.J., Keeler, C.L., Kutish, G.F., Riblet, S.M., Volkening, J.D., Zsak, L., Afonso, C.L., Mundt, E.S., Rock, D.L., Garcia, M. 2012. Comparative full genome analysis of four infectious laryngotracheitis virus (gallid herpesvirus-1) virulent isolates from the United States. Virus Genes. 44:273-85. |
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Development of a transfer plasmid for expression of foreign genes in meleagrid herpesvirus type 1
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| Spatz, S.J., Zsak, L. 2011. Development of a transfer plasmid for expression of foreign genes in meleagrid herpesvirus type 1. American Association of Avian Pathologists. 1(1):237. |
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Genotypic characterization of two bacterial artificial chromosome clones derived from a single DNA source of the very virulent gallid herpesvirus-2 strain C12/130
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| Spatz, S.J., Smith, L.P., Baigent, S.J., Petherbridge, L., Nair, V. 2011. Genotypic characterization of two bacterial artificial chromosome clones derived from a single DNA source of the very virulent gallid herpesvirus-2 strain C12/130. Journal of General Virology. 92:1500-1507 |
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Comparative genomic sequence analysis of the Marek’s disease vaccine strain SB-1
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| Spatz, S.J., Schat, K.A. 2011. Comparative genomic sequence analysis of the Marek’s disease vaccine strain SB-1. Virus Genes. 42:331-338. |
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Nucleotide sequence discrepancies within the GA strain of Marek's disease virus
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| Spatz, S.J., Lee, L.F., Silva, R.F. 2011. Nucleotide sequence discrepancies within the GA strain of Marek's disease virus. Western Poultry Disease Conference. 134-139. |
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Comparative nucleotide sequence analysis of three virulent strains of infectious laryngotracheitis virus
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| Spatz, S.J., Afonso, C.L., Zsak, L., Garcia, M., Mundt, E., Riblet, S., Keeler, C., Rock, D. 2010. Comparative nucleotide sequence analysis of three virulent strains of infectious laryngotracheitis virus. Workshop on Molecular Pathogenesis of Marek's Disease and Avian Immunology. 1(1): 59. |
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Accumulation of attenuating mutations in varying proportions within a high passage very virulent plus strain of gallid herpesvirus type 2.
- (Peer Reviewed Journal)
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| Spatz, S.J. 2010. Accumulation of attenuating mutations in varying proportions within a high passage very virulent plus strain of gallid herpesvirus type 2.Virus Res 149(2):135-42. |
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The genomes of Marek’s disease virus exist as quasispecies at defined intervals during serial passage-induced attenuation
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| Spatz, S.J., Gimeno, I.M., Witter, R.L., Heidari, M. 2010. The genomes of Marek’s disease virus exist as quasispecies at defined intervals during serial passage-induced attenuation. Western Poultry Disease Conference. 1(1):90-91. |
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Evolutionary Genomics of Marek's Disease Virus
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| Spatz, S.J. 2009. Evolutionary Genomics of Marek's Disease Virus. Meeting Proceedings. 1(1):8. |
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Accumulation of quasi-species during serial passage-induced attenuation of Marek's Disease Virus-1 (MDV-1)
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| Spatz, S.J., Gimeno, I.M., Heidari, M. 2009. Accumulation of quasi-species during serial passage-induced attenuation of Marek's Disease Virus-1 (MDV-1). American Association of Avian Pathologists. 1(1): 128. |
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Identification of Marek's disease virus genes mutated during serial passage-induced attenuation.
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| Spatz, S.J., Gimeno, I.M., Heidari, M. 2008. Identification of Marek's disease virus genes mutated during serial passage-induced attenuation.. Meeting Proceedings. 1(1): 188. |
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Clustering of mutations within the inverted repeat regions of a serially-passaged attenuated gallid herpesvirus type 2 strain.
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| Spatz, S.J., Rue, C.A., Schumacher, D., Osterrieder, N. 2008. Clustering of mutations within the inverted repeat regions of a serially-passaged attenuated gallid herpesvirus type 2 strain. Virus Genes. 37:69-80. |
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Sequence determination of a mildly virulent strain (CU-2) of Gallid herpesvirus type 2 using 454 pyrosequencing
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| Spatz, S.J., Rue, C.A. 2008. Sequence determination of a mildly virulent strain (CU-2) of Gallid herpesvirus type 2 using 454 pyrosequencing. Virus Genes. 36:479-489. |
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Characterization of the a-like sequences of attenuated and nonattenuated strains of Marek's disease virus
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| Spatz, S.J., Rue, C.A. 2007. Characterization of the a-like sequences of attenuated and nonattenuated strains of Marek's disease virus. Research Workers in Animal Diseases Conference Proceedings. p. 115. |
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Horizontal transmission of Marek’s disease virus requires both the unique-long (UL) 13 protein kinase (UL13) and the UL44 glycoprotein C
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| Jarosinski, K.W., Margulis, N.G., Kamil, J.P., Spatz, S.J., Nair, V.K., Osterrieder, N. 2007. Horizontal transmission of Marek’s disease virus requires US2, the UL13 protein kinase, and gC. Journal of Virology. Oct;81(19):10575-87. |
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Comparative sequence analysis of a highly oncogenic but horizontal spread-deficient clone of Marek's disease virus
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| Spatz, S.J., Zhao, Y., Petherbridge, L., Smith, L.P., Baigent, S.J., Nair, V. 2007. Comparative sequence analysis of a highly oncogenic but horizontal spread-deficient clone of Marek's disease virus [abstract]. 32nd Annual International Herpesvirus International Workshop. Paper No. 6.24. |
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Characterization of the a-like sequences of attenuated and nonattenuated strains of Marek's Disease Virus 1 (MDV-1)
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| Rue, C.A., Spatz, S.J. 2007. Characterization of the a-like sequences of attenuated and nonattenuated strains of Marek's Disease Virus 1 (MDV-1).[abstract]. Herpesvirus International Workshop. Poster 6.24 |
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