Publications (Clicking on the reprint icon will take you to the publication reprint.)

Transcriptome profiling reveals stage-specific production and requirement of flagella during biofilm development in Bordetella bronchiseptica - (Peer Reviewed Journal)

Nicholson, T.L., Conover, M.S., Deora, R. 2012. Transcriptome profiling reveals stage-specific production and requirement of flagella during biofilm development in Bordetella bronchiseptica. PLoS ONE. 7(11):e49166.

The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)

Brockmeier, S.L., Loving, C.L., Nelson, E.A., Miller, L.C., Nicholson, T.L., Register, K.B., Grubman, M.J., Brough, D.E., Kehrli, Jr., M.E. 2012. The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus. Clinical and Vaccine Immunology. 19(4):508-514.

Phenotypic modulation of the Bvg+ phase is not required for pathogenesis and transmission of Bordetella bronchiseptica in swine - (Peer Reviewed Journal)

Nicholson, T.L., Brockmeier, S.L., Loving, C.L., Register, K.B., Kehrli, Jr., M.E., Stibitz, S.E., Shore, S.M. 2012. Phenotypic modulation of the virulent Bvg phase is not required for pathogenesis and transmission of Bordetella bronchiseptica in swine. Infection and Immunity. 80(3):1025-1036.

Bordetella bronchiseptica in a paediatric cystic fibrosis patient: possible transmission from a household cat - (Peer Reviewed Journal)

Register, K.B., Sukumar, N., Palavecino, E.L., Rubin, B.K., Deora, R. 2012. Bordetella bronchiseptica in a paediatric cystic fibrosis patient: possible transmission from a household cat. Zoonoses and Public Health. 59(4):246-250.

Swine MRSA isolates form robust biofilms - (Abstract Only)

Nicholson, T.L. 2011. Swine MRSA isolates form robust biofilms [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 99.

Sequence and virulence comparison of four North American isolates of porcine reproductive and respiratory syndrome virus - (Abstract Only)

Brockmeier, S.L., Loving, C.L., Miller, L.C., Vorwald, A.C., Kehrli, Jr., M.E., Baker, R.B., Nicholson, T.L., Lager, K.M., Faaberg, K.S. 2011. Sequence and virulence comparison of four North American isolates of porcine reproductive and respiratory syndrome virus. Conference of Research Workers in Diseases. Paper No. 174. p. 171.

Genome sequence of Haemophilus parasuis strain 29755 - (Peer Reviewed Journal)

Mullins, M.A., Register, K.B., Bayles, D.O., Dyer, D.W., Kuehn, J.S., Phillips, G.J. 2011. Genome sequence of Haemophilus parasuis strain 29755. Standards in Genomic Sciences. 5(1):61-68.

Host response to secondary bacterial infection associated with antecedent influenza virus infection in pigs – exacerbation associated with vaccination - (Abstract Only)

Loving, C.L., Vincent, A.L., Brockmeier, S.L., Henningson, J.N., Braucher, D.R., De Souza Rajao, D. 2011. Host response to secondary bacterial infection associated with antecedent influenza virus infection in pigs - exacerbation associated with vaccination [abstract]. Autumn Immunology Conference. Poster No. 140.

Haemophilus parasuis exhibits IgA protease activity but lacks homologs of the IgA protease genes of Haemophilus influenzae - (Peer Reviewed Journal)

Mullins, M.A., Register, K.B., Bayles, D.O., Butler, J.E. 2011. Haemophilus parasuis exhibits IgA protease activity but lacks homologs of the IgA protease genes of Haemophilus influenzae. Veterinary Microbiology. 153(3-4):407-412.

Bordetellosis - (Book / Chapter)

Brockmeier, S.L., Register, K.B., Nicholson, T.L., Loving, C.L. 2012. Bordetellosis. In: Zimmerman, J., Karriker, L., Ramirez, A., Schwartz, K., Stevenson, G., editors.Diseases of Swine. 10th edition. Ames, IA: Iowa State University Press. pp. 670-679.

Pasteurellosis - (Book / Chapter)

(04-Jun-11)

A curated multi-locus sequence typing (MLST) database for Haemophilus parasuis - (Abstract Only)

(28-Feb-11)

Contribution of Bordetella bronchiseptica Type III secretion system to respiratory disease in swine - (Abstract Only)

Brockmeier, S., Nicholson, T.L., Loving, C.L., Register, K.B. 2011. Contribution of Bordetella bronchiseptica type III secretion system to respiratory disease in swine [abstract]. American Society for Microbiology 2011 Annual Meeting. Abstract No. 1494.

Porcine circovirus type 2 (PCV2) vaccination is effective in reducing disease and PCV2 shedding in semen of boars concurrently infected with PCV2 and Mycoplasma hyopneumoniae - (Peer Reviewed Journal)

Opriessnig, T., Madson, D.M., Schalk, S., Brockmeier, S., Shen, H., Beach, N.M., Meng, X.J., Baker, R.B., Zanella, E.L., Halbur, P.G. 2011. Porcine circovirus type 2 (PCV2) vaccination is effective in reducing disease and PCV2 shedding in semen of boars concurrently infected with PCV2 and Mycoplasma hyopneumoniae. Theriogenology. 76(2):351-360.

Utility of a Panviral Microarray for Detection of Swine Respiratory Viruses in Clinical Samples - (Peer Reviewed Journal)

Nicholson, T.L., Kukielka, D., Vincent, A.L., Brockmeier, S.L., Miller, L.C., Faaberg, K.S. 2011. Utility of a panviral microarray for detection of swine respiratory viruses in clinical samples. Journal of Clinical Microbiology. 49(4):1542-1548.

Immune responses elicited to a live-attenuated influenza virus vaccine compared to a traditional whole-inactivated virus vaccine for pandemic H1N1in pigs - (Abstract Only)

Loving, C.L., Vincent, A.L., Pena, L., Perez, D. 2011. Immune responses elicited to a live-attenuated influenza virus vaccine compared to a traditional whole-inactivated virus vaccine for pandemic H1N1 in pigs [abstract]. Keystone Symposium, Immunity in the Respiratory Tract. Poster No. 228. p. 163.

Innate immune responses to pathogens involved in the porcine respiratory disease complex - (Abstract Only)

Brockmeier, S.L., Loving, C.L., Vincent, A.L. 2011. Innate immune responses to pathogens involved in the porcine respiratory disease complex [abstract]. Keystone Symposia, Immunity in the Respiratory Tract. Poster No. 114. p. 149.

Innate Immune Responses are Enhanced in Pigs After Sequential Infection with Influenza Virus and Haemophilus parasuis - (Abstract Only)

Loving, C.L., Brockmeier, S.L., Vincent, A.L. 2010. Innate immune responses are enhanced in pigs after sequential infection with influenza virus and Haemophilus parasuis [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 165.

G-CSF Analogue Treatment Increases Peripheral Neutrophil Numbers in Pigs - a Potential Alternative for In-Feed Antibiotics - (Abstract Only)

Loving, C.L., Brockmeier, S.L., Bayles, D.O., Greenlee, J.J., Lager, K.M., Kehrli, Jr., M.E. 2010. G-CSF analogue treatment increases peripheral neutrophil numbers in pigs - a potential alternative for in-feed antibiotics. Conference of Research Workers in Animal Diseases. Paper No. 140.

Use of an Avirulent Isolate of Haemophilus parasuis as a Vaccine - (Abstract Only)

Brockmeier, S., Register, K.B., Loving, C.L., Nicholson, T.L. 2010. Use of an avirulent Isolate of Haemophilus parasuis as a vaccine. 45th US-Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health Meeting. p 14.

Influenza Vaccination in the Face of Maternal Antibody Results in Enhanced Pneumonia Following Heterologous, Homosubtypic Influenza Challenge - (Abstract Only)

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Gauger, P.C., Kehrli, Jr., M.E. 2010. Influenza vaccination in the face of maternal antibody results in enhanced pneumonia following heterologous, homosubtypic influenza challenge [abstract]. Keystone Symposia, Immunological Mechanisms of Vaccination. Paper No. 243.

Evaluation of the Specificity of BP3385 for Bordetella pertussis     - (Peer Reviewed Journal)

Register, K.B., Nicholson, T.L., Guthrie, J.L. 2010. Evaluation of the Specificity of BP3385 for Bordetella pertussis. Journal of Clinical Microbiology. 48(9):3334-3337.

Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions     - (Peer Reviewed Journal)

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions. Microbial Pathogenesis. 49(5):237-245.

PCV2 Vaccination Prevented Clinical PCVAD and Reduced PCV2 Viremia and Semen Shedding in Boars Concurrently Infected with PCV2b and Mycoplasma hyopneumoiae - (Proceedings)

Opriessnig, T., Madsen, D.M., Shen, H., Brockmeier, S., Beach, N., Meng, X.J. 2010. PCV2 Vaccination Prevented Clinical PCVAD and Reduced PCV2 Viremia and Semen Shedding in Boars Concurrently Infected with PCV2b and Mycoplasma hyopneumoiae. In: Proceedings of the Pig Veterinary Society International Congress, July 18-21, 2010, Vancouver, Canada. p. 427.

Prior Colonization with an Avirulent Haemophilus parasuis Isolate Prevents Disease from a Subsequent Virulent Challenge with a Heterologous Isolate - (Proceedings)

Brockmeier, S., Loving, C.L., Mullins, M., Register, K.B., Nicholson, T.L. Prior Colonization with an Avirulent Haemophilus parasuis Isolate Prevents Disease from a Subsequent Virulent Challenge with a Heterologous Isolate. In: Proceedings of the Pig Veterinary Society International Congress, July 18-21, Vancouver, Canada. p. 192.

Prior Swine Influenza Virus Infection Enhances Pulmonary Responses to Secondary Haemophilus parasuis Infection - (Proceedings)

Loving, C.L., Brockmeier, S., Vincent, A.L. 2010. Prior Swine Influenza Virus Infection Enhances Pulmonary Responses to Secondary Haemophilus parasuis Infection. In: Proceedings of the Pig Veterinary Society International Congress, July 18-21, 2010, Vancouver, Canada. p. 264.

IgA Protease Activity in Haemophilus parasuis in the Absence of a Recognizable IgA Protease Gene - (Abstract Only)

Mullins, M., Register, K.B., Butler, J.E. 2010. IgA Protease Activity in Haemophilus parasuis in the Absence of a Recognizable IgA Protease Gene [abstract]. American Society for Microbiology. Poster No. Z-500.

A Modified Multi-Locus Sequence Typing (MLST) Scheme for Haemophilus parasuis - (Proceedings)

Register, K.B., Mullins, M., Bayles, D.O. 2010. A Modified Multi-Locus Sequence Typing (MLST) Scheme for Haemophilus parasuis. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 516.

Contribution of the Bordetella Bps Polysaccharide to Biofilm Formation and Respiratory Disease in Swine - (Abstract Only)

Nicholson, T.L., Brockmeier, S., Loving, C.L., Lu, H., Sloan, G.P., Deora, R. 2010. Contribution of the Bordetella Bps Polysaccharide to Biofilm Formation and Respiratory Disease in Swine [abstract]. American Society for Microbiology. p. 123.

Antecedent Influenza Virus Infection Enhances Pulmonary Responses to Secondary Haemophilus Infection in a Porcine Co-Infection Model - (Abstract Only)

Loving, C.L., Brockmeier, S.L., Vincent, A.L. 2010. Antecedent Influenza virus infection enhances pulmonary responses to secondary Haemophilus infection in a porcine co-infection model [abstract]. American Association of Immunologists. Paper No. 803219.

Utility of a Panviral Microarray for Detection of Swine Respiratory Viruses in Clinical Samples - (Abstract Only)

Nicholson, T.L., Kukielka, D., Wang, D., Faaberg, K.S. 2009. Detection Limits of PRRSV and SIV Using Pan Viral Microarray [abstract]. 45th Meeting of the United States-Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health, December 2-4, 2009, Tokyo, Japan. p. 21.

Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions - (Abstract Only)

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions [abstract]. Conference Research Workers Disease Meeting. Paper No. 130.

Virulence and Genome Evolution of Bordetella bronchiseptica - (Abstract Only)

(07-Oct-09)

Studies of pathogenesis, transmission, heterologous protection, and genomics of four isolates of Haemophilus parasuis - (Abstract Only)

Brockmeier, S., Loving, C.L., Register, K.B., Nicholson, T.L., Bayles, D.O., Phillips, G.J. 2009. Studies of pathogenesis, transmission, heterologous protection, and genomics of four isolates of Haemophilus parasuis [abstract]. 2009 Conference of Research Workers in Diseases. Abstract No. 15, p. 118.

Studies of Pathogenesis, Transmission, and Heterologous Protection of Four Isolates of Haemophilus parasuis in a Highly Susceptible Swine Population - (Abstract Only)

Brockmeier, S., Loving, C.L., Register, K.B., Nicholson, T.L., Bayles, D.O., Phillips, G.J. 2010. Studies of pathogenesis, transmission, and heterologous protection of four isolates of Haemophilus parasuis in a highly susceptible swine population [abstract]. 2010 American Association of Swine Veterinarians Annual Meeting. p. 127-129.

Microarray and functional analysis of growth-phase dependent gene regulation in Bordetella bronchiseptica - (Peer Reviewed Journal)

Nicholson, T.L., Buboltz, A.M., Harvill, E.T., Brockmeier, S.L. 2009. Microarray and Functional Analysis of Growth-Phase Dependent Gene Regulation in Bordetella bronchiseptica. Infection and Immunity. 77(10):4221-4231.

Characterization and comparative analysis of the genes encoding Haemophilus parasuis outer membrane proteins P2 and P5 - (Peer Reviewed Journal)

Mullins, M.A., Register, K.B., Bayles, D.O., Loving, C.L., Nicholson, T.L., Brockmeier, S.L., Dyer, D.W., Phillips, G.J. 2009. Characterization and Comparative Analysis of the Genes Encoding Haemophilus parasuis Outer Membrane Proteins P2 and P5. Journal of Bacteriology. 191(19):5988-6002.

Enhanced Type III Secretion System activity contributes to the increased virulence of a Bordetella bronchiseptica lineage - (Peer Reviewed Journal)

Buboltz, A.M., Nicholson, T.L., Weyrich, L.S., Harvill, E.T. 2009. Role of the Type III Secretion System in a Hypervirulent Lineage of Bordetella bronchiseptica. Infection and Immunity. 77(9):3969-3977.

Evidence for horizontal gene transfer of two antigenically distinct O antigens in Bordetella bronchiseptica - (Peer Reviewed Journal)

Buboltz, A., Nicholson, T.L., Karanikas, A., Preston, A., Harvill, E. 2009. Evidence for horizontal gene transfer of two antigenically distinct O antigens in Bordetella bronchiseptica. Infection and Immunity. 77(8):3249-3257.

Identification and Comparative Analysis of Genes Encoding Outer Membrane Proteins P2 and P5 in Haemophilus parsuis - (Abstract Only)

Mullins, M.A., Register, K.B., Bayles, D.O., Loving, C.L., Nicholson, T.L., Brockmeier, S.L., Dyer, D.W., Phillips, G.J. 2009. Identification and comparative analysis of genes encoding outer membrane proteins P2 and P5 in Haemophilus parsuis [abstract]. 109th American Society for Microbiology General Meeting. Poster No. Z-034.

Contribution of Bordetella bronchiseptica Filamentous Hemagglutinin and Pertactin to Respiratory Disease in Swine - (Peer Reviewed Journal)

Nicholson, T.L., Brockmeier, S., Loving, C.L. 2009. Contribution of Bordetella bronchiseptica Filamentous Hemagglutinin and Pertactin to Respiratory Disease in Swine. Infection and Immunity. 77(5):2136-2146.

Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus - (Peer Reviewed Journal)

Brockmeier, S., Lager, K.M., Grubman, M.J., Brough, D.E., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Loving, C.L., Vorwald, A.C., Kehrli Jr, M.E., Lehmkuhl, H.D. 2009. Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus. Viral Immunology. 22(3):173-180.

Bordetella - (Book / Chapter)

Register, K., Harvill, E. 2010. Bordetella. In: Gyles, C.L., Prescott, J.F., Songer, J.G., Thoen, C.O., editors. Pathogenesis of Bacterial Infections in Animals. 4th edition. Wiley-Blackwell, Ames, IA. p. 411-427.

Replacement of adenylate cyclase toxin in a lineage of Bordetella bronchiseptica - (Peer Reviewed Journal)

Buboltz, A.M., Nicholson, T.L., Parette, M.R., Hester, S.E., Parkhill, J., Harvill, E. 2008. Replacement of adenylate cyclase toxin in a lineage of Bordetella bronchiseptica. Journal of Bacteriology. 190(15):5502-5511.

Differences in immune response of pigs challenged with a high versus low dose inoculum of porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Lager, K.M., Sacco, R.E. 2008. Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus. Viral Immunology. 21(3):315-325.

Investigating the porcine immune reponse to Haemophilus parasuis - (Abstract Only)

(15-May-08)

Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica - (Proceedings)

Brockmeier, S., Vincent, A.L., Loving, C.L., Nicholson, T.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica. In: Proceedings of the 20th International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. 1:10.

Strain-specific virulence of Bordetella hinzii in turkeys - (Abstract Only)

Register, K.B., Kunkle, R.A. 2008. Strain-specific virulence of Bordetella hinzii in turkeys [abstract]. American Society for Microbiology Annual Meeting. Poster No. Z-023.

Bordetella bronchiseptica Bvg Phase-Dependent Contribution to Colonization, Transmission, and Immune Responses in Pigs - (Abstract Only)

Loving, C.L., Nicholson, T.L., Brockmeier, S. 2008. Bordetella bronchiseptica Bvg Phase-Dependent Contribution to Colonization, Transmission, and Immune Responses in Pigs [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.

Contribution of Bordetella bronchiseptica Filamentous Hemagglutinin and Pertactin to Respiratory Disease in Swine - (Abstract Only)

Nicholson, T.L., Brockmeier, S., Loving, C.L. 2008. Contribution of Bordetella bronchiseptica Filamentous Hemagglutinin and Pertactin to Respiratory Disease in Swine [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.

Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica - (Abstract Only)

Brockmeier, S., Loving, C.L., Nicholson, T.L., Vincent, A.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.

DNA vaccines against infectious agents: recent strategies for enhancing immune responses - (Review Article)

Sacco, R.E. 2008. DNA vaccines against infectious agents: Recent strategies for enhancing immune responses. Expert Opinion on Therapeutic Patents. 18(4):365-373.

Replacement of Adenylate Cyclase Toxin in a Prominent Lineage of Bordetella bronchiseptica - (Proceedings)

Buboltz, A.M., Nicholson, T.L., Parette, M.R., Hester, S.E., Parkhill, J., Harvill, E.T. 2008. Replacement of Adenylate Cyclase Toxin in a Prominent Lineage of Bordetella bronchiseptica. Keystone Symposium Molecular Evolution as a Driving Force in Infectious Disease, April 8-13, 2008, Breckenridge, Colorado. p. 16.

Bordetella bronchiseptica Pneumonia in an Infant and Genetic Comparison of Clinical Isolates with Veterinary Kennel Cough Vaccines - (Peer Reviewed Journal)

Rath, B.A., Register, K.B., Wall, J., Sokol, D.M., Van Dyke, R.B. 2008. Bordetella bronchiseptica Pneumonia in an Infant and Genetic Comparison of Clinical Isolates with Veterinary Kennel Cough Vaccines. Clinical Infectious Diseases. 46(6):905-908.

Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica - (Abstract Only)

Brockmeier, S., Vincent, A.L., Nicholson, T.L., Sacco, R.E., Palmer, M.V. 2007. Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. In: United States Japan Natural Resources Animal and Avian Health Panel, December 5, 2007, Tsukuba, Japan. p. 25.

Growth Phase dependent gene regulation in Bordetella bronchiseptica - (Abstract Only)

(12-Nov-07)

Misidentification of Bordetella bronchiseptica as Bordetella pertussis using a Newly Described RT-PCR Targeting the Pertactin Gene - (Peer Reviewed Journal)

Register, K.B., Nicholson, T.L. 2007. Misidentification of Bordetella bronchiseptica as Bordetella pertussis using a newly described RT-PCR targeting the pertactin gene. Journal of Medical Microbiology. 56:1608-1610.