Page Banner

United States Department of Agriculture

Agricultural Research Service

Related Topics

Research Project: TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES: THE ROLE OF GENETICS, STRAIN VARIATION, AND ENVIRONMENTAL CONTAMINATION IN DISEASE CONTROL

Location: Animal Diseases Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Transmissibility of caprine scrapie in ovine transgenic mice     Reprint Icon - (Peer Reviewed Journal)
Orourke, K.I., Schneider, D.A., Spraker, T.R., Dassayanake, R., Highland, M., Zhuang, D., Truscott, T.C. 2012. Transmissibility of caprine scrapie in ovine transgenic mice. BioMed Central (BMC) Veterinary Research. 8:42.
Disease-associated prion protein in neural and lymphoid tissues of mink (Mustela vison) inoculated with transmissible mink encephalopathy     Reprint Icon - (Peer Reviewed Journal)
Schneider, D.A., Harrington, R., Zhuang, D., Yan, H., Truscott, T.C., Dassanayake, R., Orourke, K.I. 2012. Disease-associated prion protein in neural and lymphoid tissues of mink (Mustela vison) inoculated with transmissible mink encephalopathy. Journal of Comparative Pathology. 147:508-521.
Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222     Reprint Icon - (Peer Reviewed Journal)
White, S.N., Reynolds, J.O., Waldron, D.F., Schneider, D.A., Orourke, K.I. 2012. Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222. Gene. 501(1):49-51.
The role of genetics in chronic wasting disease of North American cervids - (Peer Reviewed Journal)
Robinson, S.J., Samuel, M.D., Orourke, K.I., Johnson, C.J. 2012. The role of genetics in chronic wasting disease of North American cervids. Prion. 6(2):153-162.
Cell surface expression of PrP-c and the presence of scrapie prions in the blood of goats - (Peer Reviewed Journal)
Dassanayake, R.P., Schneider, D.A., Hoesing, L.M., Truscott, T.C., Davis, W.C., Orourke, K.I. 2012. Cell surface expression of PrP-c and the presence of scrapie prions in the blood of goats. Journal of General Virology. 1127-1131.
Classical scrapie prions in ovine blood are associated with B lymphocytes and platelets-rich plasma     Reprint Icon - (Peer Reviewed Journal)
Dassanayake, R.P., Schneider, D.A., Truscott, T.C., Young, A.J., Zhuang, D., Orourke, K.I. 2011. Classical scrapie prions in ovine blood are associated with B lymphocytes and platelets-rich plasma. BioMed Central (BMC) Veterinary Research. 7:75.
Cytokine antibody array analysis in brain and periphery of scrapie-infected Tg338 mice - (Peer Reviewed Journal)
Newsom, D.M., Liggitt, H.D., Orourke, K.I., Zhuang, D., Schneider, D.A., Harrington, R.D. 2011. Cytokine antibody array analysis in brain and periphery of scrapie-infected Tg338 mice. Comparative Immunology Microbiology and Infectious Diseases. 34(5):387-97.
Resistance of fallow deer (dama dama) to chronic wasting disease under natural exposure in a heavily contaminated environment - (Peer Reviewed Journal)
Rhyan, J.C., Spraker, T.R., Mccollum, M., Nol, P., Wolfe, L., Miller, M.W., Davis, T., Creekmore, L., Orourke, K.I. 2009. Resistance of fallow deer (dama dama) to chronic wasting disease under natural exposure in a heavily contaminated environment. Journal of Wildlife Diseases. 47(3):739-744.
Scant PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie - (Peer Reviewed Journal)
Orourke, K.I., Zhuang, D., Truscott, T.C., Yan, H., Schneider, D.A. 2011. Scant PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie. BioMed Central (BMC) Veterinary Research. 7(1):7.
Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk - (Peer Reviewed Journal)
White, S.N., Spraker, T.R., Reynolds, J.O., Orourke, K.I. 2010. Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk. BMC Research Notes. 3:314.
The bovine spleen: Interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections     Reprint Icon - (Review Article)
Goff, W.L., Bastos, R.G., Brown, W.C., Johnson, W.C., Schneider, D.A. 2010. The bovine spleen: interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections. Veterinary Immunology and Immunopathology. 138:1-14.
Identification of atypical scrapie in Canadian sheep - (Peer Reviewed Journal)
Mitchell, G.B., Orourke, K.I., Harrington, N.P., Soutyrine, A., Simmons, M.M., Dudas, S., Zhuang, D., Laude, H., Balachandran, A. 2010. Identification of atypical scrapie in Canadian sheep. Canadian Veterinary Journal. 22(3):402-408.
Detection of the Abnormal Isoform of the Prion Protein Associated With Chronic Wasting Disease in the Optic Pathways of the Brain and Retina of Rocky Mountain Elk (Cervus elaphus nelsoni)     Reprint Icon - (Peer Reviewed Journal)
Spraker, T.R., Orourke, K.I., Gidlewski, T.L., Powers, J., Greenlee, J.J., Wild, M.A. 2010. Detection of the Abnormal Isoform of the Prion Protein Associated With Chronic Wasting Disease in the Optic Pathways of the Brain and Retina of Rocky Mountain Elk (Cervus elaphus nelsoni). Veterinary Pathology. 47(3):536-546.
Genetic population structure and relatedness of Colorado mule deer (Odocoileus hemionus) and incidence of chronic wasting disease - (Peer Reviewed Journal)
(14-Oct-09)
Molecular genealogy tools for white-tailed deer with chronic wasting disease - (Peer Reviewed Journal)
Ernest, H., Hoar, B.R., Well, J.A., Orourke, K.I. 2010. Molecular genealogy tools for white-tailed deer with chronic wasting disease. Canadian Journal of Veterinary Research. 74(2):152-156.
Sensitive detection of PrPCWD in rectoanal mucosa-associated lymphoid tissue from preclinical white-tailed deer     Reprint Icon - (Abstract Only)
Schneider, D.A., Orourke, K.I., Balachandran, A., Keane, D. 2009. Sensitive Detection of PrPCWD in Rectoanal Mucosa-Associated Lymphoid Tissue from Preclinical White-Tailed Deer. United States Animal Health Association Proceedings. pg.224-225.
Prion genotypes of scrapie-infected Canadian sheep 1998-2008 - (Peer Reviewed Journal)
Harrington, N., Orourke, K.I., Feng, Y., Rendulich, J., Difruscio, C., Balachandran, A. 2010. Prion genotypes of scrapie-infected Canadian sheep 1998-2008. Canadian Journal of Veterinary Research. 74(3):228-232.
Diagnosis of preclinical CWD in farmed white-tailed deer in Canada by the immunohistochemical examination of recto-anal mucosa- associated lymphoid tissue (RAMALT)     Reprint Icon - (Abstract Only)
Balachandran, A., Thomsen, B.V., Gidlewski, T., Spraker, T.R., Mitchell, G., Soutyrine, A., Harrington, N.P., Munger, R., Schneider, D.A., Orourke, K.I. 2009. Diagnosis of preclinical CWD in farmed white-tailed deer in Canada by the immunohistochemical examination of recto-anal mucosa- associated lymphoid tissue (RAMALT). NeuroPrion Workshop: New developments in TSEs of domestic and wild animals. pg.9
Validation of Use of Rectoanal Mucosa-Associated Lymphoid Tissue for Immunohistochemical Diagnosis of Chronic Wasting Disease in White-Tailed Deer (Odocoileus virginianus)     Reprint Icon - (Peer Reviewed Journal)
Keane, D., Barr, D., Osborn, R., Langenberg, J., Orourke, K.I., Schneider, D.A., Bochsler, P. 2009. Validation of Use of Rectoanal Mucosa-Associated Lymphoid Tissue for Immunohistochemical Diagnosis of Chronic Wasting Disease in White-Tailed Deer (Odocoileus virginianus). Journal of Veterinary Diagnostic Investigation. 47(5):1412-1417.
Nor98 scrapie identified in the United States     Reprint Icon - (Peer Reviewed Journal)
Loiacono, C.M., Thomsen, B.V., Hall, S.M., Kiupel, M., Sutton, D., Orourke, K.I., Barr, B., Anthenill, L., Collins, J., Keane, D. 2009. Nor98 scrapie identified in the United States. Journal of Veterinary Diagnostic Investigation. 21(4):454-463.
Chronic Wasting Disease Prions in Elk Antler Velvet     Reprint Icon - (Peer Reviewed Journal)
Angers RC, Seward TS, Napier D, Green M, Hoover E, Spraker T, et al. 2009. Chronic wasting disease prions in elk antler velvet. Emerg Infect Dis 15(5):696-703.
Blood chimerism confounds genetic relative susceptibility testing for classical scrapie in sheep     Reprint Icon - (Peer Reviewed Journal)
Schneider, D.A., Tibary, A., Raudsepp, T., Das, P.J., Orourke, K.I. 2009. Blood chimerism confounds genetic relative susceptibility testing for classical scrapie in sheep. Journal of Veterinary Diagnostic Investigation. 21(3):295-305.
Increased risk of chronic wasting disease in Rocky Mountain elk associated with decreased magnesium and increased manganese in brain tissue     Reprint Icon - (Peer Reviewed Journal)
White, S.N., Orourke, K.I., Gidlewski, T.L., Vercauteren, K.C., Mousel, M.R., Phillips, G.E., Spraker, T.R. 2010. Increased risk of chronic wasting disease in Rocky Mountain elk associated with decreased magnesium and increased manganese in brain tissue. Canadian Journal of Veterinary Research. 74:50-53.
Experimental oral transmission of chronic wasting disease to red deer (Cervus elaphus elaphus): Early detection and late stage distribution of protease-resistant prion protein     Reprint Icon - (Peer Reviewed Journal)
Balachandran, A., Harrington, N., Algire, J., Souyrine, A., Spraker, T., Jeffrey, M., Gonzalez, L., Orourke, K.I. 2010. Experimental oral transmission of chronic wasting disease to red deer (Cervus elaphus elaphus): Early detection and late stage distribution of protease-resistant prion protein. Canadian Veterinary Journal. Canadian Veterinary Journal. 51:169-178.
Antemortem detection of PrP-CWD in preclinical, ranch-raised Rocky Mountain elk (Cervus elaphus nelsoni) by biopsy of the rectal mucosa     Reprint Icon - (Peer Reviewed Journal)
Spraker, T.R., Vercauteren, K.C., Gidlewski, T., Schneider, D.A., Munger, R., Balanchandran, A., Orourke, K.I. 2009. Antemortem detection of PrP-CWD in preclinical, ranch-raised Rocky Mountain elk (Cervus elaphus nelsoni) by biopsy of the rectal mucosa. Journal of Veterinary Diagnostic Investigation. 21(1):15-24.
Small-Ruminant Lentivirus Enhances PrP-Sc Accumulation in Cultured Sheep Microglial Cells     Reprint Icon - (Peer Reviewed Journal)
Stanton, J.B., Knowles Jr, D.P., Orourke, K.I., Hoesing, L.M., Mathison, B.A., Baszler, T.V. 2008. Small-Ruminant Lentivirus Enhances PrP-Sc Accumulation in Cultured Sheep Microglial Cells. Journal of Virology. 82(20):9839-9847.
Chronic wasting disease in a Wisconsin white-tailed deer farm - (Peer Reviewed Journal)
Keane, D.P., Barr, D.J., Bochsler, P.N., Hall, S.M., Gidlewski, T.E., O'Rourke, K.I., Spraker, T.R., Samuel, M.D. 2008. Chronic wasting disease in a Wisconsin white-tailed deer farm. Journal of Veterinary Diagnostic Investigation. 20(5):698-703.
Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie - (Peer Reviewed Journal)
Schneider, D.A., Yan, H., Fry, L.M., Alverson, J., White, S.N., Orourke, K.I. 2008. Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie. Acta Neuropathologica. 115(6):651-661.
A species barrier limits transmission of chronic wasting disease to mink (Mustela vison)     Reprint Icon - (Peer Reviewed Journal)
Harrington, R.D., Baszler, T.V., Orourke, K.I., Schneider, D.A., Spraker, T.R., Liggitt, H.D., Knowles Jr, D.P. 2008. A species barrier limits transmission of chronic wasting disease to mink (Mustela vison). Journal of General Virology. 89(4):1086-1096.
A collaborative Canadian-United Kingdom evaluation of an immunohistochemistry protocol to diagnose bovine spongiform encephalopathy - (Peer Reviewed Journal)
Manning, L., Orourke, K.I., Knowles Jr, D.P., Marsh, S., Spencer, Y.I., Moffat, E., Wells, G.A., Czub, S. 2008. A collaborative Canadian-United Kingdom evaluation of an immunohistochemistry protocol to diagnose bovine spongiform encephalopathy. Journal of Veterinary Diagnostic Investigation. 20(4):113-117.
Elk with a long incubation prion disease phenotype have a unique PrP-d profile - (Peer Reviewed Journal)
O'Rourke, K.I., Spraker, T.R., Zhuang, D., Greenlee, J.J., Gidlewski, T.E., Hamir, A.N. 2007. Elk with a long incubation prion disease phenotype have a unique PrP-d profile. NeuroReport. 18(18):1935-1938.
Transfection of non-susceptible cells with Ovis aries recombinant lymphocyte function-associated antigen 1 renders susceptibility to Mannheimia haemolytica leukotoxin - (Peer Reviewed Journal)
Lawrence, P.K., Dassanayake, R.P., Knowles Jr, D.P., Srikumaran, S. 2007. Transfection of non-susceptible cells with Ovis aries recombinant lymphocyte function-associated antigen 1 renders susceptibility to Mannheimia haemolytica leukotoxin. Veterinary Microbiology. 125(1-2):91-99.
Last Modified: 9/1/2014
Footer Content Back to Top of Page