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United States Department of Agriculture

Agricultural Research Service

Research Project: DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Quantitative analysis of oxyresveratrol in different plant parts of Morus species and related Genera by HPTLC - (Peer Reviewed Journal)
Ayinampudi, S.R., Wang, Y., Avula, B., Smillie, T.J., Khan, I.A. 2011. Quantitative analysis of oxyresveratrol in different plant parts of Morus species and related Genera by HPTLC . Journal of Chromatography B. 24(2):125-129.
Bioavailability, Pharmacokinetics and Tissue Distribution of P57AS3 (P57) from Hoodia gordonii Mouse Model - (Peer Reviewed Journal)
Madgula, V., Ashfaq, M.K., Wang, Y., Avula, B., Khan, I.A., Walker, L.A., Khan, S.I. 2010. Bioavailability, Pharmacokinetics and Tissue Distribution of P57AS3 (P57) from Hoodia gordonii Mouse Model. Biopharmaceutics and Drug Disposition. DOI http://dx.doi.org/10.10ee/S-1055-1249818.
Effects of Synephrine and B-Phenethylamine on Human a-Adrenoceptor Subtypes - (Peer Reviewed Journal)
Ma, G., Bavadekar, S.A., Schaneberg, B.T., Khan, I.A., Feller, D.R. 2010. Effects of Synephrine and B-Phenethylamine on Human a-Adrenoceptor Subtypes. Planta Medica. 76(10):981-986.
A New ent-Labdane Diterpene Glycoside form the Leaves of Casearia sylvestris - (Peer Reviewed Journal)
Wang, W., Ali, Z., Li, X., Khan, I.A. 2010. A New ent-Labdane Diterpene Glycoside form the Leaves of Casearia sylvestris. Natural Product Communications. 5(5):771-774.
Triterpenoids from two Terminalia species - (Peer Reviewed Journal)
Wang, W., Ali, Z., Li, X., Shen, Y., Khan, I.A. 2010. Triterpenoids from Two Terminalia Species. Planta Medica. DOI http://dx.doi.org/10.1055/s-0030-1249809.
Microbial Metabolism. Part 11. Metabolites of Flutamide - (Peer Reviewed Journal)
Heratch, W., Khan, I.A. 2010. Microbial Metabolism. Part 11. Metabolites of Flutamide. Chemical and Pharmaceutical Bulletin. 58(4):562-564.
Two New Triterpene Glycosides from Centella asiatica - (Peer Reviewed Journal)
Rumalla, C.S., Ali, Z., Weerasooriyaa, A.D., Smillie, T., Khan, I.A. 2010. Two New Triterpene Glycosides from Centella asiatica. Planta Medica. 76:1018-1021.
Ursane Triterpenoids from the Bark of Terminalia arjuna - (Peer Reviewed Journal)
Wang, W., Ali, Z., Shen, Y., Li, X., Khan, I.A. 2010. Ursane Triterpenoids from the Bark of Terminalia arjuna. Fitoterapia. 81:480-484.
18, 19-Secooleanane Type Triterpene Glycosyl Esters from the Bark of Terminalia Arjuna - (Peer Reviewed Journal)
Wang, W., Ali, Z., Li, X., Shen, Y., Khan, I.A. 2010. 18, 19-Secooleanane Type Triterpene Glycosyl Esters from the Bark of Terminalia arjuna. Planta Medica. 76:903-908.
Neolignans from the Leaves of Casearia sylvestris Swartz - (Peer Reviewed Journal)
Wang, W., Ali, Z., Li, X., Khan, I.A. 2009. Neolignans from the Leaves of Casearia sylvestris Swartz. Helvetica Chimica Acta. 93(1):139-146.
4-Arylflavan-3-ols as Proanthocyanidin Models: Absolute Configuration via Density Functional Calculation of Electronic Circular Dichroism - (Peer Reviewed Journal)
Ding, Y., Li, X., Ferreira, D. 2010. 4-Arylflavan-3-ols as Proanthocyanidin Models: Absolute Configuration via Density Functional Calculation of Electronic Circular Dichroism. Journal of Natural Products. 73:435-440.
ent-Kaurane Glycosides from Tricalysia okelensis - (Peer Reviewed Journal)
Xu, W., Jacob, M.R., Agarwal, A.K., Clark, A.M., Liang, Z., Li, X. 2009. ent-Kaurane Glycosides from Tricalysia okelensis. Chemical and Pharmaceutical Bulletin. 58:261-264.
Determination of absolute configuration of natural products: theoretical calculation of electronic circular dichroism as a tool - (Peer Reviewed Journal)
Li, X., Ferreria, D., Ding, Y. 2010. Determination of absolute configuration of natural products: theoretical calculation of electronic circular dichroism as a tool. Current Organic Chemistry. 14:1678-1697.
Unique Discovery Aspects of Utilizing Botanical Sources - (Book / Chapter)
Manly, S.P., Smillie, T., Hester, J.P., Khan, I., Coudurier, L. 2010. Unique Discovery Aspects of Utilizing Botanical Sources in Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery. Taosheng Chen, Ed., CRC Press, Boca Raton, FL. PP 213-232.
Triterpenoids from Brazilian Ginseng, Pfaffia paniculata - (Peer Reviewed Journal)
Li, J., Jadhav, A.N., Khan, I.A. 2009. Triterpenoids from Brazilian Ginseng, Pfaffia paniculata. Planta Medica. 75:1-5.
Intestinal and Blood-Brain Barrier Permeability of Ginkgolides and Bilobalide: In Vitro and In Vivo Approaches - (Peer Reviewed Journal)
Madgula, V.L., Yu, Y., Avula, B., Wang, Y.H., Tchantchou, F., Fisher, S., Luo, Y., Khan, I.A., Khan, S.I. 2010. Intestinal and Blood-Brain Barrier Permeability of Ginkgolides and Bilobalide: In Vitro and In Vivo Approaches. Planta Medica. 76:599-606.
Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in Cell-Based Assay - (Peer Reviewed Journal)
Bialonska, D., Kasimsetty, S.G., Khan, S.I., Ferreira, D. 2009. Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in Cell-Based Assay. Journal of Agricultural and Food Chemistry. 57(21):10181-10186.
Structure and Function of Plasmodium falciparum malate dehydrogenase: Role of Critical Amino Acids in C-substrate Binding Procket - (Peer Reviewed Journal)
Pradhan, A., Tripathi, A.K., Desai, P.V., Mukherjee, P.K., Avery, M.A., Walker, L.A., Tekwani, B.L. 2009. Structure and Function of Plasmodium falciparum malate dehydrogenase: Role of Critical Amino Acids in C-substrate Binding Procket. Biochimie. 91:1509-1517.
Puupehanol, a Sesquiterpene-Dihydroquinone Derivative from the Marine Sponge Hyrtios sp - (Peer Reviewed Journal)
Xu, W., Ding, Y., Jacob, M.R., Agarwal, A.K., Clark, A.M., Ferreira, D., Liang, Z., Li, X. 2009. Puupehanol, a Sesquiterpene-Dihydroquinone Derivative from the Marine Sponge Hyrtios sp. Bioorganic and Medicinal Chemistry Letters. 19:6140-6143.
Clerodane and Ent-kaurane Diterpene Glycosyl and Glycoside Derivatives from the Leaves of Casearia sylvestris - (Peer Reviewed Journal)
Wang, W., Ali, Z., Li, X., Khan, I.A. 2009. Clerodane and Ent-kaurane Diterpene Glycosyl and Glycoside Derivatives from the Leaves of Casearia sylvestris. Helvetica Chimica Acta. 92:1829-1839.
Flavonol Glycosides from Gaura Biennis - (Peer Reviewed Journal)
Xu, W., Jacob, M.R., Agarwal, A.K., Clark, A.M., Liang, Z., Li, X. 2009. Flavonol Glycosides from Gaura Biennis. Heterocycles. 78:2541-2548.
Characterization of in Vitro Pharmacokinetic Properties of Hoodigogenin A from Hoodia gordonii - (Peer Reviewed Journal)
Madgula, V.L., Avula, B., Pawar, R.S., Shukla, Y.J., Khan, I.A., Walker, L.A., Khan, S.I. 2010. Characterization of in Vitro Pharmacokinetic Properties of Hoodigogenin A from Hoodia gordonii. Planta Medica. 76:62-69.
Verbesinosides A-F, Novel 15,27-Cyclooleanane Saponins from the American Native Plant Verbesina virginica - (Peer Reviewed Journal)
Xu, W., Jacob, M.R., Agarwal, A.K., Clark, A.M., Liang, Z., Li, X. 2009. Verbesinosides A-F, Novel 15,27-Cyclooleanane Saponins from the American Native Plant Verbesina virginica . Journal of Natural Products. 72:1022-1027.
Diterpenoids from Casearia sylvestris - (Peer Reviewed Journal)
Wang, W., Zhao, J., Wang, Y., Smillie, T.A., Li, X., Khan, I.A. 2009. Diterpenoids from Casearia sylvestris. Planta Medica. 75(13):1436-1441.
Antimicrobial, Antiparasitic and Cytotoxic Spermine Alkaloids from Albizia schimperiana - (Peer Reviewed Journal)
Samoylenko, V., Jacob, M.R., Khan, S.I., Zhao, J., Tekwani, B.L., Midiwo, J.O., Walker, L.A., Muhammad, I. 2009. Antimicrobial, Antiparasitic and Cytotoxic Spermine Alkaloids from Albizia schimperiana. Natural Product Communications. 4(6):791-796.
Beyond Polymaxenolide: Cembrane-Africanane Terpenoids from the Hybrid Soft Coral Sinularia maxima x S. polydactyla - (Peer Reviewed Journal)
Kamel, H.N., Ding, Y., Li, X., Ferreira, D., Fronczek, F.R., Slattery, M. 2009. Beyond Polymaxenolide: Cembrane-Africanane Terpenoids from the Hybrid Soft Coral Sinularia maxima x S. polydactyla. Journal of Natural Products. 72:900-905.
Microbial Metabolism. Part 10. Metabolites of 7,8 Dimethoxyflavone and 5-Methoxyflavone - (Peer Reviewed Journal)
Herath, W., Mikell, J.R., Khan, I.A. 2009. Microbial Metabolism. Part 10. Metabolites of 7,8 Dimethoxyflavone and 5-Methoxyflavone . Natural Product Research. 23(13):1231-1239.
Synthesis and Antimalarial Activities of Cyclen 4-Aminoquinoline Analogs - (Peer Reviewed Journal)
Khan, M., Levi, M.S., Tekwani, B.L., Khan, S.I., Kimura, E., Borne, R.F. 2009. Synthesis and Antimalarial Activities of Cyclen 4-Aminoquinoline Analogs. Antimicrobial Agents and Chemotherapy. 53(4):1320-1324.
Analysis of Quaternary Structure of a [LDH-like] Malate Dehydrogenase of Plasmodium falciparum with Oligomeric Mutants - (Peer Reviewed Journal)
Pradhan, A., Mukherjee, P., Tripathi, A.K., Avery, M.A., Walker, L.A., Tekwani, B.L. 2009. Analysis of Quaternary Structure of a [LDH-like] Malate Dehydrogenase of Plasmodium falciparum with Oligomeric Mutants. Molecular and Cellular Biochemistry. 325:141-148.
Bioactive (+)-Manzamine A and (+)-Hydroxymanzamine A Tertiary Bases and Salts from Acanthostrongylophora ingens and Their Preparations - (Peer Reviewed Journal)
Samoylenko, V., Khan, S.I., Jacob, M.R., Tekwani, B.L., Walker, L.A., Hufford, C.D., Muhammad, I. 2009. Bioactive (+)-Manzamine A and (+)-Hydroxymanzamine A Tertiary Bases and Salts from Acanthostrongylophora ingnes and Their Preparations. Natural Product Communications. 4(2):185-192.
Indolizidine, Antiinfective and Antiparasitic Compounds from Prosopis glandulosa var. glandulosa - (Peer Reviewed Journal)
Samoylenko, V., Ashfaq, M.K., Jacob, M.R., Tekwani, B.L., Khan, S.I., Manly, S.P., Joshi, V.C., Walker, L.A., Muhammad, I. 2009. Indolizidine, Antiinfective and Antiparasitic Compounds from Prosopis glandulosa var. glandulosa. Journal of Natural Products. 72(1):92-98.
Rp-Hplc Determination of Phenylalkanoids and Monoterpenoids in Rhodiola Rosea and Identification by Lc-Esi-Tof - (Peer Reviewed Journal)
Avula, B., Wang, Y., Ali, Z., Smillie, T.J., Filion, V., Cuerrier, A., Arnason, J.T., Khan, I.A. 2009. RP-HPLC Determination of Phenylalkanoids and Monoterpenoids in Rhodiola rosea and Identification by LC-ESI-TOF. Biomedical Chromatography. 23(8):865-872.
Soyasaponin Bh, a Triterpene Saponin Containing a Unique Hemiacetal-Functional Five-Membered Ring from Glycine max (Soybeans)     Reprint Icon - (Peer Reviewed Journal)
Ali, Z., Khan, S.I., Khan, I.A. 2009. Soyasaponin Bh, a Triterpene Saponin Containing a Unique Hemiacetal-Functional Five-Membered Ring from Glycine max (Soybeans). Planta Medica. 75:371-374.
Theoretical Calculation of Electronic Circular Dichroism of a Hexahydroxydiphenoyl-Containing Flavanone Glycoside - (Peer Reviewed Journal)
Ding, Y., Li, X., Ferreira, D. 2009. Theoretical Calculation of Electronic Circular Dichroism of a Hexahydroxydiphenoyl-Containing Flavanone Glycoside. Journal of Natural Products. 72(3):327-335.
Alkaloids and Saponins as Cytochrome P450 Inhibitors from Blue Cohosh (Caulophyllum thalictroides) in an In Vitro Assay - (Peer Reviewed Journal)
Madgula, V.L., Ali, Z., Smillie, T., Khan, I.A., Walker, L.A., Khan, S.I. 2009. Alkaloids and Saponins as Cytochrome P450 Inhibitors from Blue Cohosh (Caulophyllum thalictroides) in an In Vitro Assay. Planta Medica. 75:329-332.
Lanostane-Type Triterpenes from the Mushroom Astraeus pteridis with Antituberculosis Activity - (Peer Reviewed Journal)
Stanikunaite, R., Radwan, M.M., Trappe, J.M., Fronczek, F., Ross, S.A. 2008. Lanostane-Type Triterpenes from the Mushroom Astraeus pteridis with Antituberculosis Activity. Journal of Natural Products. 71(12):2077-2079.
Determination of Shikimic Acid in Fruits of Illicium Species and Various Other Plant Samples by LC-UV and LC-ESI-MS - (Peer Reviewed Journal)
Avula, B., Wang, Y., Smillie, T.J., Khan, I.A. 2009. Determination of Shikimic Acid in Fruits of Illicium Species and Various Other Plant Samples by LC-UV and LC-ESI-MS. Chromatographia. 69(3/4):307-314.
Variability in In Vitro Macrophage Activation by Commercially Diverse Bulk Echinacea Plant Material is Predominantly Due to Bacterial Lipoproteins and Lipopolysaccharides - (Peer Reviewed Journal)
Tamta, H., Pugh, N.D., Balachandran, P., Moraes, R., Sumiyanto, J., Pasco, D.S. 2008. Variability in In Vitro Macrophage Activation by Commercially Diverse Bulk Echinacea Plant Material is Predominantly Due to Bacterial Lipoproteins and Lipopolysaccharides. Journal of Agricultural and Food Chemistry. 56(22):10552-10556.
Anti-Aromatase Activity of the Constituents from Damiana (Turnera diffusa)     Reprint Icon - (Peer Reviewed Journal)
Zhao, J., Dasmahapatra, A.K., Khan, S.I., Khan, I.A. 2008. Anti-Aromatase Activity of the Constituents from Damiana (Turnera diffusa). Journal of Ethnopharmacology. 120:387-393.
Sorocenols G and H, Anti-MRSA Oxygen Heterocyclic Diels-Alder-type Adducts from Sorocea muriculata Roots - (Peer Reviewed Journal)
Ross, S.A., Rodriguez-Guzman, R., Radwan, M.M., Jacob, M., Ding, Y., Li, X., Ferreira, D., Manly, S.P. 2008. Sorocenols G and H, Anti-MRSA Oxygen Heterocyclic Diels-Alder-type Adducts from Sorocea muriculata Roots. Journal of Natural Products. 71(10):1764-1767.
Cyclooxygenase-2 Inhibitory and Antioxidant Compounds from the Truffle Elaphomyces granulatus - (Peer Reviewed Journal)
Stanikunaite, R., Khan, S.I., Trappe, J.M., Ross, S.A. 2009. Cyclooxygenase-2 Inhibitory and Antioxidant Compounds from the Truffle Elaphomyces granulatus. Phytotherapy Research. 23:575-578.
Antiparasitic, Nematicidal and Antifouling Constituents from Juniperus Berries - (Peer Reviewed Journal)
Samoylenko, V., Dunbar, D., Gafur, M., Khan, S.I., Ross, S.A., Mossa, J.S., El-Feraly, F.S., Tekwani, B.L., Bossalaers, J., Muhammad, I. 2008. Antiparasitic, Nematicidal and Antifouling Constituents from Juniperus Berries. Phytotherapy Research. 22:1570-1576.
Genomic Approaches to Understanding Allelochemical Effects on Plants - (Book / Chapter)
Duke, S.O., Baerson, S.R., Pan, Z., Kagan, I., Sanchez-Moreiras, A., Reigosa, M.J., Pedrol, N., Schulz, M. Genomic Approaches to Understanding Allelochemical Effects on Plants. In "Allelopathy in Sustainable Agriculture and Forestry", eds. R.S. Zeng, A.U. Mallik, and S.M. Luo, Springer, New York, NY, pp. 157-167.
Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress Within a Hormetic Dose-Response Framework - (Peer Reviewed Journal)
Calabrese, E.J., Bailer, A., Bachmann, K.A., Bolger, P., Borak, J., Cai, L., Cedergreen, N., Chiueh, C.C., Cherian, M., Clarkson, T.W., Cook, R.R., Diamond, D.M., Doolittle, D.J., Dorato, M.A., Duke, S.O., Feinendegen, L., Gardner, D.E., Hart, R.W., Hastings, K.L., Hayes, A.W., Hoffman, G.R., Jaworowski, Z., Johnson, T.E., Keller, J.G., Klaunig, J.E., Knudsen, T.B., Kozumbo, W.J., Lettieri, T., Liu, S., Maisseu, A., Maynard, K., Masoro, E.J., Mothersil, C., Newlin, D.B., Oehme, F.W., Phalen, R.F., Philbert, M.A., Rattan, S., Riviere, J.E., Rodricks, J., Sapolsky, R.M., Scott, B.R., Seymour, C., Smith-Sonneborn, J., Snow, E.T., Spear, L., Stevenson, D.E., Thomas, Y., Williams, G.M., Mattson, M.P. 2007. Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress Within a Hormetic Dose-Response Framework. Journal of Toxicology and Applied Pharmacology. 222:122-128.
p-Hydroxyphenylpyruvate Dioxygenase is a Herbicidal Target Site for B-triketones from Leptospermum Scoparium     Reprint Icon - (Peer Reviewed Journal)
Dayan, F.E., Duke, S.O., Sauldubois, A., Singh, N., Mccurdy, C., Cantrell, C.L. 2007. p-Hydroxyphenylpyruvate Dioxygenase is a Herbicidal Target Site for B-triketones from Leptospermum Scoparium. Phytochemistry. 68:2004-2014.
The Occurrence of Hormesis in Plants and Algae - (Peer Reviewed Journal)
Cedergreen, N., Streibig, J.C., Kudsk, P., Mathiassen, S.K., Duke, S.O. 2007. The occurrence of hormesis in plants and algae. Dose Response. V. 5:150-162.
Natural Products That Have Been Used Commercially As Crop Protection Agents - A Review - (Review Article)
Copping, L.G., Duke, S.O. 2007. Natural Products That Have Been Used Commercially As Crop Protection Agents - A Review. Pest Management Science. 63:524-554.
A Plethora of Polyketides: Structures, Biological Activities and Enzymes - (Book / Chapter)
Baerson, S.R., Rimando, A.M. 2007. A Plethora of Polyketides: Structures, Biological Activities and Enzymes. American Chemical Society Symposium Series. In Polyketides: Biosynthesis, Biological Activity and Genetic Engineering, A. Rimando and S. Baerson, eds., American Chemical Society, Washington, DC. pp. 2-14.
Last Modified: 10/23/2014
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