Start Date: Feb 08, 2006
End Date: Feb 07, 2011
The approaches involve in vivo and in vitro studies using animal and plant models and epidemiological studies to evaluate human exposure to toxins and risk for mycotoxin associated diseases. For the processing objective mass balance studies will be conducted comparing toxin levels in starting material to that in final product. For other objectives mechanism based bioassays will be developed to assess plant derived toxins in foods and for assessing the efficacy of processing methods. Plant and animal models will be used to develop mechanism-based markers of resistance and susceptibility to disease.