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United States Department of Agriculture

Agricultural Research Service

Research Project: DEVELOPMENT OF DETECTION TECHNOLOGIES FOR TOXINS AND THEIR VALIDATION IN FOOD MATRICES Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Auto-presentation of Staphylococcal enterotoxin A by mouse CD4+ T cells - (Peer Reviewed Journal)
Rasooly, R., Do, P.M., Hernlem, B.J. 2011. Auto-presentation of Staphylococcal enterotoxin A by mouse CD4+ T cells. Open Journal of Immunology. 1(1):8-14. doi:10.4236/oji.2011.11002.
Comparison of oral toxicological properties of botulinum neurotoxin - (Peer Reviewed Journal)
Cheng, L.W., Henderson II, T.D. 2011. Comparison of oral toxicological properties of botulinum neurotoxin. Toxicon. 58:62-67.
Detection of ricin contamination in ground beef by electrochemiluminescence immunosorbent assay - (Peer Reviewed Journal)
Brandon, D.L. 2011. Detection of ricin contamination in ground beef by electrochemiluminescence immunosorbent assay. Toxins. 3(4):398-408.
Sensitive detection of Shiga toxin 2 and some of its Stx 2 variants in environmental samples by a novel immuno-PCR assay - (Peer Reviewed Journal)
He, X., Qi, W., Quinones, B., Mcmahon, S.A., Cooley, M.B., Mandrell, R.E. 2011. Sensitive detection of Shiga toxin 2 and some of its Stx 2 variants in environmental samples by a novel immuno-PCR assay. Applied and Environmental Microbiology. 77(1):3558-3564. doi:10.1128/AEM.02205-10.
Neuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A - (Peer Reviewed Journal)
Pellett, S., Tepp, W.H., Stanker, L.H., Band, P.A., Johnson, E.A., Ichtchenko, K. 2011. Neuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A. Biochemical and Biophysical Research Communications. 405:673-677.
Detection of benzimidazole carbamates and amino metabolites in liver by surface plasmon resonance-biosensor - (Peer Reviewed Journal)
Keegan, J., O'Kennedy, R., Crooks, S., Elliott, C.T., Brandon, D.L., Danaher, M. 2011. Detection of benzimidazole carbamates and amino metabolites in liver by surface plasmon resonance-biosensor. Analytica Chimica Acta. 700(1-2):41-48.
Immunoassay - (Book / Chapter)
Brandon, D.L., Carter, J.M. 2012. Immunoassay. Sun, D.W. Handbook of Food Safety Engineering. Oxford, UK:Wiley-Blackwell. P. 279-312.
Microbead-based immunoassay for simultaneous detection of Shiga toxins and isolation of Escherichia coli O157 in foods - (Peer Reviewed Journal)
Clotilde, L.M., Hartman, G.L., Lau, D.K., Carter, J.M. 2011. Microbead-based immunoassay for simultaneous detection of Shiga toxins and isolation of Escherichia coli O157 in foods. Journal of Food Protection. 74(3):373-379.
Clostridium botulinum neurotoxin type B is heat-stable in milk and not inactivated by pasteurization - (Peer Reviewed Journal)
Rasooly, R., Do, P.M. 2010. Clostridium botulinum neurotoxin type B is heat-stable in milk and not inactivated by pasteurization. Journal of Agricultural and Food Chemistry. 58:12557-12561.
Botulinum neurotoxin: a deadly protease with applications to human medicine - (Book / Chapter)
Land, K.M., Cheng, L.W. 2010. Botulinum neurotoxin: a deadly protease with applications to human medicine. Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology. Spain. Formatex Research Center. 965-971.
Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR - (Peer Reviewed Journal)
He, X., Mcmahon, S.A., Henderson II, T.D., Griffey, S.M., Cheng, L.W. 2010. Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR. PLoS One. 5(9):e12858. doi:10.1371/journal.pone.0012858.
Ingested Shiga Toxin 2 (Stx2) Causes Histopathological Changes in Kidney, Spleen and Thymus Tissues and Mortality in Mice - (Peer Reviewed Journal)
Rasooly, R., Do, P.M., Griffey, S.M., Vilches-Moure, J.G., Friedman, M. 2010. Ingested Shiga Toxin 2 (Stx2) Causes Histopathological Changes in Kidney, Spleen and Thymus Tissues and Mortality in Mice. Journal of Agricultural and Food Chemistry. (58):9821-9286
Detection of Botulinum Neurotoxin Serotype B at Sub Mouse LD50 Levels by a Sandwich Immunoassay and its Application to Toxin Detection in Milk - (Peer Reviewed Journal)
Scotcher, M.C., Cheng, L.W., Stanker, L.H. 2010. Detection of Botulinum Neurotoxin Serotype B at Sub Mouse LD50 Levels by a Sandwich Immunoassay and its Application to Toxin Detection in Milk. PLos One. 5(6):e11047.doi:10.1371/journal.pone.0011047.
Inhibition of Biological Activity of Staphylococcal Enterotoxin A (SEA) by Apple Juice and Apple Polyphenols - (Peer Reviewed Journal)
Rasooly, R., Do, P.M., Friedman, M. 2010. Inhibition of Biological Activity of Staphylococcal Enterotoxin A (SEA) by Apple Juice and Apple Polyphenols. Journal of Agricultural and Food Chemistry. 58:5421-5426.
Development of a Luminex Immunoassay for Simultaneous Detection of Shiga toxins and Escherichia coli O157 in Ground Beef - (Abstract Only)
Bernard Iv, C., Hartman, G.L., Lau, D.K., Carter, J.M., Clotilde, L.M. 2010. Development of a Luminex Immunoassay for Simultaneous Detection of Shiga toxins and Escherichia coli O157 in Ground Beef. [Abstract]. American Chemical Society National Meeting Poster #AGFD#172.
Inhibition of Shiga Toxin 2 (Stx2) in Apple Juices and its Resistance to Pasteurization - (Peer Reviewed Journal)
Rasooly, R., Do, P.M., Levin, C.E., Friedman, M. 2010. Inhibition of Shiga Toxin 2 (Stx2) in Apple Juices and its Resistance to Pasteurization. Applied and Environmental Microbiology. Vol. 75(5):M296-M301.
Development of a Novel Immuno-PCR Assay for Detection of Ricin in Ground Beef, Liquid Chicken Egg and Milk - (Peer Reviewed Journal)
He, X., McMahon, S.A., McKeon, T.A., Brandon, D.L. 2010. Development of a Novel Immuno-PCR Assay for Detection of Ricin in Ground Beef, Liquid Chicken Egg and Milk. Journal of Food Protection. 73(4):695-700
Comparison of Toxicological Properties of Botulinum Neurotoxin Serotypes A and B in Mice - (Abstract Only)
Cheng, L.W., Henderson Ii, T.D., Scotcher, M.C., Stanker, L.H. 2009. Comparison of Toxicological Properties of Botulinum Neurotoxin Serotypes A and B in Mice. American Chemical Society [Abstract]. Paper No. 26541
Dual fluorochrome flow cytometric assessment of yeast viability - (Peer Reviewed Journal)
Hernlem, B.J., Hua, S.T. 2010. Dual fluorochrome flow cytometric assessment of yeast viability. Current Microbiology. 61:57-63.
Shiga toxin Stx2 is heat-stable and not inactivated by pasteurization     Reprint Icon - (Peer Reviewed Journal)
Rasooly, R., Do, P.M. 2009. Shiga toxin Stx2 is heat-stable and not inactivated by pasteurization. International Journal of Food Microbiology. 136(2010):290-294
Benzimidazole Carbamate Residues in Milk: Detection by SPR Biosensor; using a Modified QuEChERS Method for Extraction - (Peer Reviewed Journal)
Keegan, J., Whelan, M., Danaher, M., Crooks, S., Sayers, R., Anastasio, A., Elliott, C., Brandon, D.L., Furey, A., O'Kennedy, R. 2009. Benzimidazole Carbamate Residues in Milk: Detection by SPR Biosensor; using a Modified QuEChERS Method for Extraction. Analytica Chimica Acta.Volume(2009):111-119
Antibody Protection Against Botulinum Neurotoxin Intoxication In Mice - (Peer Reviewed Journal)
Cheng, L.W., Stanker, L.H., Henderson Ii, T.D., Lou, J., Marks, J.D. 2009. Antibody Protection Against Botulinum Neurotoxin Intoxication In Mice. Infection and Immunity. 77(10):4305-4313.
Detection of Protein Toxins - (Abstract Only)
Brandon, D.L., Cheng, L.W., He, X., Rasooly, R., Scotcher, M.C., Stanker, L.H., Carter, J.M. 2009. Detection of Protein Toxins. Meeting Abstract. Poster No. 8.
Detection and Recovery of Shiga Toxins and Escherichia Coli O157 - (Abstract Only)
Clotilde, L.M., Carter, J.M., Bernard Iv, C. 2009. Detection and Recovery of Shiga Toxins and Escherichia Coli O157. [Abstract]. Planet xMAP Luminex meeting Abstract #16.
Characterization of the epitope region of F1-2 and F1-5, two monoclonal antibodies to Botulinum Neurotoxin Type A - (Peer Reviewed Journal)
Scotcher, M.C., Johnson, E.A., Stanker, L.H. 2009. Characterization of the epitope region of F1-2 and F1-5, two monoclonal antibodies to Botulinum Neurotoxin Type A. Hybridoma. 28(5):315-325
Botulinum Neurotoxin Research at the Western Regional Research Center - (Abstract Only)
(09-Apr-09)
Validation of a Cell-Free Translation Assay for Detecting Shiga Toxin 2 in Bacterial Culture - (Peer Reviewed Journal)
He, X., Quinones, B., Carter, J.M., Mandrell, R.E. 2009. Validation of a Cell-Free Translation Assay for Detecting Shiga Toxin 2 in Bacterial Culture. Journal of Agriculture and Food Chemistry. 57(11):5084-5088
In vitro cell based assay for activity analysis of staphylococcal enterotoxin A in food - (Peer Reviewed Journal)
Rasooly, R., Do, P.M. 2009. In vitro cell based assay for activity analysis of staphylococcal enterotoxin A in food. FEMS Immunology and Medical Microbiology 56(2009): 172-178.
Development of monoclonal antibodies specific for Ricinus agglutinins - (Peer Reviewed Journal)
Brandon, D.L., Hernlem, B.J. 2009. Development of monoclonal antibodies specific for Ricinus agglutinins. Food and Agricultural Immunology. 20(1):11-22
Botox and Our Tax Dollars at Work - (Other)
(06-Oct-08)
Immunochemical technologies for replacement of rodent bioassays in sensitive detection of toxins in foods - (Proceedings)
Carter, J.M., Cheng, L.W., He, X., Rasooly, R., Brandon, D.L., Stanker, L.H. 2010. Immunochemical technologies for replacement of rodent bioassays in sensitive detection of toxins in foods. Proceedings from Biodetection Technologies 6th Edition. 5:75-95.
Global challenges/chemistry solutions: Promoting personal safety and national security - (Popular Publication)
(02-Jul-08)
Effect of food matrices on the biological activity of ricin - (Peer Reviewed Journal)
He, X., Lu, S.S., Cheng, L.W., Rasooly, R., Carter, J.M. 2008. Effect of food matrices on the biological activity of ricin. Journal of Food Protection 71(10):2053-2058.
Bactericidal activity of the food color additive Phloxine B against Staphylococcus aureus and other food borne microbial pathogens - (Abstract Only)
(20-May-08)
In vitro peptide cleavage assay for detection of Botulinum Neurotoxin-A activity in food - (Peer Reviewed Journal)
Rasooly, R., Do, P.M. 2008. In vitro peptide cleavage assay for detection of Botulinum Neurotoxin-A activity in food. Applied and Environmental Microbiology. 74(14):4309-4313
Detection of botulinum neurotoxin-A activity in food by peptide cleavage assay - (Peer Reviewed Journal)
Rasooly, R., Stanker, L.H., Carter, J.M., Do, P.M., Cheng, L.W., He, X., Brandon, D.L. 2008. In vitro peptide cleavage assay for detection of Botulinum Neurotoxin-A activity in food. International Journal of Food Microbiiology. 126 (2008):135-139
Effects of purification on the bioavailability of botulinum neurotoxin type A - (Peer Reviewed Journal)
Cheng, L.W., Onisko, B.C., Johnson, E.A., Reader, J.R., Griffey, S.M., Larson, A.E., Tepp, W.H., Stanker, L.H., Brandon, D.L., Carter, J.M. 2008. Effects of purification on the bioavailability of botulinum neurotoxin type A. Toxicology. 249(2008):123-129.
Development and Partial Characterization of High-affinity Monoclonal Antibodies for Botulinum Toxin Type A and their use in Analysis of Milk by Sandwich ELISA - (Peer Reviewed Journal)
Stanker, L.H., Merrill, P.A., Scotcher, M.C., Cheng, L.W. 2008. Development and Partial Characterization of High-affinity Monoclonal Antibodies for Botulinum Toxin Type A and their use in Analysis of Milk by Sandwich ELISA. Journal of Immunological Methods, 336:1-8.
Optical Immunosencor and Conventional Elisa for the Analysis of Pyrethroids and Ddt in Environmental Samples - (Book / Chapter)
Kramer, P.M., Weber, C.M., Kremmer, E., Rauber, C., Martens, D., Forester, S., Stanker, L.H., Rauch, P., Shiundu, P.M., Mulaa, F.J. 2007. Optical immunosencor and Conventional Elisa for the Analysis of Pyrethroids and DDT in Environmental Samples. Kennedy I.R., Solomon K., Gee S., Crosnan A., Wang S. 1ST Edition. New York, NY: University Press. p. 186-202.
Application of a real time PCR method to detect castor toxin contamination in fluid milk and eggs - (Peer Reviewed Journal)
He, X., Carter, J.M., Brandon, D.L., Cheng, L.W., Mckeon, T.A. 2007. Application of a real time PCR method to detect castor toxin contamination in fluid milk and eggs. Journal of Agricultural and Food Chemistry. 55:6897-6902
Molecular Approaches for the Identification of Toxin in Foods - (Abstract Only)
(23-Feb-07)
Detection of castor contamination by real-time polymerase chain reaction - (Peer Reviewed Journal)
He, X., Brandon, D.L., Chen, G.Q., McKeon, T.A., Carter, J.M. 2007. Detection of castor contamination by real-time polymerase chain reaction. Journal of Agricultural and Food Chemistry. 55(2):545-550.
Phloxine B, aversatile bacterial stain - (Peer Reviewed Journal)
Rasooly, R. 2007. Phloxine B, aversatile bacterial stain. International Journal of Food Microbiology.157: 29-34.
Development of High Affinity Monoclonal Antibodies Specific for Botulinum Neurotoxin Type A and a Sensitive Immunoassay with Detection Near that of the Mouse Bioassay - (Abstract Only)
Stanker, L.H., Merrill, P.A. 2006. Development of High Affinity Monoclonal Antibodies Specific for Botulinum Neurotoxin Type A and a Sensitive Immunoassay with Detection Near that of the Mouse Bioassay [abstract]. ICCVAN, NICEAM/ECVAM Scientific Workshop on alternative methods to refine reduce and replace the mouse LD50 assay for botulinum testing Silver Springs, MD, 28, Nov 13-14, 2006.
Bioavailability of Crude Ricin in Food Matrices - (Abstract Only)
Cheng, L.W., Brandon, D.L., He, X., Chen, G.Q., Carter, J.M. 2006. Bioavailability of crude ricin in food matrices. [Abstract]. ACS National Meeting and Exposition. Poster AGFD 64
Development of New Monoclonal Antibodies Specific for Botulinum Neurotoxin Type A - (Abstract Only)
Stanker, L.H., Merrill, P.A., Cheng, L.W., Carter, J.M., Brandon, D.L. 2006. Development of new monoclonal antibodies specific for botulinum neurotoxin type a. [Abstract]. ACS National Meeting. Oral Presentation AGRO 235.
Development of Monoclonal Antibodies Specific for Ricin - (Abstract Only)
Brandon, D.L., Cheng, L.W., He, X., Carter, J.M. 2006. Development of monoclonal antibodies specific for ricin. [Abstract]. ACS National Meeting and Exposition. Oral Presentation AGRO 234
Development of a Sensitive Magnetic Particle Immunoassay for Permethrin - (Abstract Only)
Fernando, R., Parrotta, C.D., Kamp, L., Church, J., Stanker, L.H. 2006. Development of a sensitive magnetic particle immunoassay for permethrin. [Abstract]. ACS National Meeting and Exposition. Poster Number AGRO 153.
Detection of Castor Contamination in Ground Beef by Real-Time Pcr - (Abstract Only)
He, X., Brandon, D.L., Chen, G.Q., Mckeon, T.A., Carter, J.M. 2006. Detection of castor contamination in ground beef by real-time pcr. [Abstract]. ACS National Meeting and Exposition. Poster AGFD 18.
Last Modified: 9/10/2014
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